Journal ArticleDOI
Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae
Paul R. Carlier,Troy D. Anderson,Dawn M. Wong,Danny C. Hsu,Joshua A. Hartsel,Ming Ma,Eric A. Wong,Ranginee Choudhury,Polo C.-H. Lam,Maxim Totrov,Jeffrey R. Bloomquist +10 more
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A preliminary pharmacological characterization of An.About:
This article is published in Chemico-Biological Interactions.The article was published on 2008-09-25. It has received 53 citations till now. The article focuses on the topics: Anopheles gambiae & Anopheles.read more
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Book ChapterDOI
Malaria distribution, prevalence, drug resistance and control in Indonesia.
TL;DR: This chapter examines malaria and its control in Indonesia from the earliest efforts by malariologists of the colonial Netherlands East Indies through the Global Malaria Eradication Campaign of the 1950s, the tumult following the coup d'état of 1965, the global resurgence of malaria through the 1980s and 1990s and finally through to the decentralization of government authority following the fall of the authoritarian Soeharto regime in 1998.
Journal ArticleDOI
Neurotoxicity and Mode of Action of N, N-Diethyl-Meta-Toluamide (DEET)
TL;DR: Findings suggest DEET is likely targeting octopaminergic synapses to induce neuroexcitation and toxicity in insects, while acetylcholinesterase in both insects and mammals has low sensitivity to DEET.
Journal ArticleDOI
Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides.
TL;DR: This review summarizes the literature data that support the hypothesis that an insect-specific cysteine residue located at the opening of the acetylcholinesterase active site is a promising target site for developing new insecticides with reduced off-target toxicity and low propensity for insect resistance.
Journal ArticleDOI
Baculovirus expression, biochemical characterization and organophosphate sensitivity of rBmAChE1, rBmAChE2, and rBmAChE3 of Rhipicephalus (Boophilus) microplus.
TL;DR: The presence of at least three genes expressing AChEs in R. (B.) microplus, at least two of which contain mutations expressed as OP-insensitive enzymes, strongly suggests that phenotypic resistance to OPs may be complex and multigenic in character.
Journal ArticleDOI
Catalytic enantioselective Friedländer condensations: facile access to quinolines with remote stereogenic centers.
Le Li,Daniel Seidel +1 more
TL;DR: The desymmetrization of 4-substituted cyclohexanones upon reaction with o-aminobenzaldehydes allows for the synthesis of quinolines with remote stereogenic centers and heterocycles obtained with high levels of enantioselectivity serve as precursors for chiral tacrine analogues.
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Journal ArticleDOI
The Protein Data Bank
Helen M. Berman,John D. Westbrook,Zukang Feng,Gary L. Gilliland,Talapady N. Bhat,Helge Weissig,Ilya N. Shindyalov,Philip E. Bourne +7 more
TL;DR: The goals of the PDB are described, the systems in place for data deposition and access, how to obtain further information and plans for the future development of the resource are described.
Journal ArticleDOI
A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
Journal ArticleDOI
Multiple sequence alignment with the Clustal series of programs
Ramu Chenna,Hideaki Sugawara,Tadashi Koike,Rodrigo Lopez,Toby J. Gibson,Desmond G. Higgins,Julie D. Thompson +6 more
TL;DR: The Clustal series of programs, widely used in molecular biology for the multiple alignment of both nucleic acid and protein sequences and for preparing phylogenetic trees, are extended.
Journal ArticleDOI
Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein
Joel L. Sussman,Michal Harel,Felix Frolow,Christian Oefner,Adrian Goldman,Lilly Toker,Israel Silman +6 more
TL;DR: Modeling of acetylcholine binding to the enzyme suggests that the quaternary ammonium ion is bound not to a negatively charged "anionic" site, but rather to some of the 14 aromatic residues that line the gorge.