Journal ArticleDOI
Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis.
TLDR
The aim of this review is to provide insights into the integration of transcriptional regulation of gluconeogenic enzyme genes in response to nutritional and hormonal changes, and to indicate their essential roles in the control of this vital metabolic process.About:
This article is published in The International Journal of Biochemistry & Cell Biology.The article was published on 2012-01-01. It has received 159 citations till now. The article focuses on the topics: Transcription coregulator & Transcription Coactivator.read more
Citations
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Journal ArticleDOI
De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose.
TL;DR: Whether DNL plays a significant role in the pathogenesis of insulin resistance is yet to be fully elucidated, but it may be that the prevalent products of this synthetic process induce some aspect of hepatic insulin resistance.
Journal ArticleDOI
Clocks, Metabolism, and the Epigenome
Dan Feng,Mitchell A. Lazar +1 more
TL;DR: Recent advances in understanding the crosstalk between the circadian clock and energy metabolism through epigenomic programming and transcriptional regulation are reviewed.
Journal ArticleDOI
Cell-Type-Specific Profiling of Gene Expression and Chromatin Binding without Cell Isolation: Assaying RNA Pol II Occupancy in Neural Stem Cells
Tony D. Southall,Katrina S. Gold,Boris Egger,Catherine M. Davidson,Elizabeth E. Caygill,Owen J. Marshall,Andrea H. Brand +6 more
TL;DR: It is shown that TaDa can be used to identify transcribed genes in a cell-type-specific manner with considerable temporal precision, enabling the identification of differential gene expression between neuroblasts and the neuroepithelial cells from which they derive.
Journal ArticleDOI
Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice.
Cuiqing Liu,Xiaohua Xu,Yuntao Bai,Tse-Yao Wang,Xiaoquan Rao,Aixia Wang,Lixian Sun,Zhekang Ying,Liubov V. Gushchina,Andrei Maiseyeu,Masako Morishita,Qinghua Sun,Jack R. Harkema,Sanjay Rajagopalan +13 more
TL;DR: PM2.5 mediates IR by regulating VAT inflammation, hepatic lipid metabolism, and glucose utilization in skeletal muscle via both CCR2-dependent and -independent pathways, providing new mechanistic links between air pollution and metabolic abnormalities underlying IR.
Journal ArticleDOI
Molecular mechanisms of hypolipidemic effects of curcumin
TL;DR: The proposed molecular mechanisms by which curcumin, a polyphenol present in the rhizomes of turmeric (Curcuma longa) spice, influences oxidative and lipid‐mediated stress in the vascular system are reviewed.
References
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Journal ArticleDOI
Insulin signalling and the regulation of glucose and lipid metabolism
Alan R. Saltiel,C. Ronald Kahn +1 more
TL;DR: The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide, and tissues such as muscle, fat and liver become less responsive or resistant to insulin.
Journal ArticleDOI
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Anne Brunet,Lora B. Sweeney,J. Fitzhugh Sturgill,Katrin F. Chua,Paul L. Greer,Yingxi Lin,Hien Tran,Sarah E. Ross,Raul Mostoslavsky,Haim Y. Cohen,Linda Hu,Hwei-Ling Cheng,Mark P. Jedrychowski,Steven P. Gygi,David A. Sinclair,Frederick W. Alt,Michael E. Greenberg +16 more
TL;DR: One way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance.
Journal ArticleDOI
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Joseph T. Rodgers,Carlos Lerin,Wilhelm Haas,Steven P. Gygi,Bruce M. Spiegelman,Pere Puigserver +5 more
TL;DR: It is shown that the Sir2 homologue, SIRT1 controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1α, and this findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan.
Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
TL;DR: The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?
Journal ArticleDOI
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
TL;DR: PGC-1 alpha constitutes one of the first and clearest examples in which biological programs are chiefly regulated by a transcriptional coactivator in response to environmental stimuli and its control of energy homeostasis suggests that it could be a target for anti-obesity or diabetes drugs.
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Insulin signalling and the regulation of glucose and lipid metabolism
Alan R. Saltiel,C. Ronald Kahn +1 more