Book ChapterDOI
Transcriptional regulation in neutrophils: teaching old cells new tricks.
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This article is published in Advances in Immunology.The article was published on 2004-01-01. It has received 30 citations till now. The article focuses on the topics: Transcriptional regulation & Regulation of gene expression.read more
Citations
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Journal ArticleDOI
NF-kappaB and the immune response.
TL;DR: The role of the NF-κB pathway in the development and functioning of the immune system has been discussed in this article, where a review of the role of this pathway is presented.
Journal ArticleDOI
NF-κB in immunobiology.
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: This review will focus on areas of recent progress while also providing a broad overview of the roles of NF-κB in mammalian immunobiology.
Journal ArticleDOI
Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link
Lena Lavie,Peretz Lavie +1 more
TL;DR: Oxidative stress is a crucial component in obesity, sympathetic activation and metabolic disorders such as hypertension, dyslipidaemia and type 2 diabetes/insulin resistance, which aggregate with OSAHS and the conditions and comorbidities that aggregate with it.
Journal ArticleDOI
Role of neutrophils in innate immunity: a systems biology-level approach.
TL;DR: The systems biology‐level approaches used to gain an enhanced view of the role of neutrophils during host‐pathogen interaction are reviewed and it is anticipated that these and future systems‐level studies will ultimately provide information critical to the understanding, treatment, and control of diseases caused by pathogenic microorganisms.
Journal ArticleDOI
Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production.
Yasuhiko Koga,Hiroaki Tsurumaki,Haruka Aoki-Saito,Makiko Sato,Masakiyo Yatomi,Kazutaka Takehara,Takeshi Hisada +6 more
TL;DR: The crosstalk between extracellular signal-related kinase (ERK) 1/2 and p38 MAPK signalling has been shown to regulate various physiological functions, including central nervous system, cardiac fibrosis, alcoholic cardiac Fibrosis, osteoclast differentiation, mucin production in the airway, vascular smooth muscle cell migration, steroidogenesis and asthmatic inflammation.
References
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Journal ArticleDOI
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
TL;DR: CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS.
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STATs and Gene Regulation
TL;DR: The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.
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Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
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AP-1 function and regulation.
TL;DR: This work has shown that regulation by heterodimerization between Jun, Fos and ATF proteins, AP-1 activity is regulated through interactions with specific protein kinases and a variety of transcriptional coactivators, and there has been considerable progress in understanding some of the mechanisms and signaling pathways involved in the regulation of AP.
Journal ArticleDOI
NF-κB at the crossroads of life and death
Michael Karin,Anning Lin +1 more
TL;DR: The choice between life and death is one of the major events in regulation of the immune system and a major regulator of such life or death decisions is the transcription factor NF-κB as mentioned in this paper.