Journal ArticleDOI
Transferrin-coated magnetic upconversion nanoparticles for efficient photodynamic therapy with near-infrared irradiation and luminescence bioimaging
TLDR
A green-synthesis route to NaYF4:Gd3+,Yb3+,Er3+ upconversion nanoparticles (UCNPs) by using eco-friendly paraffin liquid, instead of 1-octadecene, as a high boiling non-coordinating solvent is devised to demonstrate the innovative design and development of high-performance multifunctional PDT agents.Abstract:
In the present study, we devised a green-synthesis route to NaYF4:Gd3+,Yb3+,Er3+ upconversion nanoparticles (UCNPs) by using eco-friendly paraffin liquid, instead of 1-octadecene, as a high boiling non-coordinating solvent. A multifunctional nanoplatform was then developed by coating UCNPs with biocompatible transferrin (TRF) for magnetically-assisted and near-infrared light induced photodynamic therapy and bioimaging. Protoporphyrin IX (PpIX), a clinically approved photodynamic therapy agent, was loaded into the shell layer of the TRF-coated UCNPs (UCNP@TRF nanoparticles), which can be efficiently taken up by cancer cells for photodynamic therapy. Upon near-infrared light irradiation, the UCNP@TRF-PpIX nanoparticles could not only kill the cancer cells via photodynamic therapy but also serve as imaging probes. We also demonstrated that an external magnetic field could be used to increase the uptake of UCNP@TRF-PpIX nanoparticles by MDA-MB-231 and HeLa cancer cells, and hence result in an enhanced photodynamic therapy efficiency. This work demonstrates the innovative design and development of high-performance multifunctional PDT agents.read more
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Precise nanomedicine for intelligent therapy of cancer
Huabing Chen,Zhanjun Gu,An Hongwei,An Hongwei,Chunying Chen,Chunying Chen,Jie Chen,Jie Chen,Ran Cui,Siqin Chen,Wei-Hai Chen,Xuesi Chen,Xuesi Chen,Xiaoyuan Chen,Zhuo Chen,Baoquan Ding,Qian Dong,Qin Fan,Ting Fu,Da-Yong Hou,Qiao Jiang,Hengte Ke,Xiqun Jiang,Gang Liu,Suping Li,Tianyu Li,Zhuang Liu,Guangjun Nie,Muhammad Ovais,Muhammad Ovais,Dai-Wen Pang,Nasha Qiu,Youqing Shen,Huayu Tian,Huayu Tian,Chao Wang,Hao Wang,Zi-Qi Wang,Huaping Xu,Jiang Fei Xu,Xiangliang Yang,Shuang Zhu,Xianchuang Zheng,Xian-Zheng Zhang,Yanbing Zhao,Weihong Tan,Weihong Tan,Xi Zhang,Yuliang Zhao +48 more
TL;DR: The recent advances of intelligent cancer nanomedicine are demonstrated, and the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanotechine including various imaging and therapeutic applications, as well as nanotoxicity is discussed.
Journal ArticleDOI
Colloidal Synthesis of Semiconductor Quantum Dots toward Large Scale Production: A Review
TL;DR: A comprehensive overview on the synthesis of colloidal QDs prepared via chemical approaches in solution phase, with emphasis on green routes which possess the advantages of environment-friendly raw materials, simple operation process, and robust mass-scale production is presented in this paper.
Journal ArticleDOI
Photodynamic Therapy—Current Limitations and Novel Approaches
TL;DR: A review of the mechanisms of action in terms of photodynamic therapy in cancer, including the effects on immune system and vasculature as well as mechanisms related with tumor cell destruction, is provided in this paper.
Journal ArticleDOI
Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment
Muhammad Ovais,Muhammad Ovais,Sudip Mukherjee,Arindam Pramanik,Devlina Das,Anubhab Mukherjee,Abida Raza,Chunying Chen,Chunying Chen +8 more
TL;DR: An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided and will result in more effective clinical translation.
Journal ArticleDOI
Lanthanide Doped Near Infrared Active Upconversion Nanophosphors: Fundamental Concepts, Synthesis Strategies, and Technological Applications.
TL;DR: A comprehensive overview of lanthanide doped NIR active UCNP is provided by discussing the fundamental concepts including the different mechanisms proposed for explaining the upconversion processes, followed by the different strategies employed for the synthesis of these materials, and finally the technological applications of UCNP by highlighting the recent works in these areas.
References
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Journal ArticleDOI
Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping
Feng Wang,Yu Han,C. S. Lim,Yunhao Lu,Juan Wang,Jun Xu,Hongyu Chen,Chun Zhang,Minghui Hong,Minghui Hong,Xiaogang Liu +10 more
TL;DR: The results suggest that the doping-induced structural and size transition, demonstrated here in NaYF4 upconversion nanocrystals, could be extended to other lanthanide-doped nanocrystal systems for applications ranging from luminescent biological labels to volumetric three-dimensional displays.
Journal ArticleDOI
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
TL;DR: Applications in Theranostics Guanying Chen,*,†,‡ Hailong Qiu,*,‡ and Xiaoyuan Chen.
Journal ArticleDOI
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
Journal ArticleDOI
Upconversion nanophosphors for small-animal imaging
Jing Zhou,Zhuang Liu,Fuyou Li +2 more
TL;DR: In this critical review, recent reports regarding the synthesis of water-soluble UCNPs and their surface modification and bioconjugation chemistry are summarized and the applications ofUCNPs for small-animal imaging, including tumor-targeted imaging, lymphatic imaging, vascular imaging and cell tracking are reviewed in detail.
Journal ArticleDOI
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
Niagara Muhammad Idris,Muthu Kumara Gnanasammandhan,Jing Zhang,Paul C. Ho,Ratha Mahendran,Yong Zhang +5 more
TL;DR: This work used mesoporous-silica–coated upconversion fluorescent nanoparticles (UCNs) as a nanotransducer to convert deeply penetrating near-infrared light to visible wavelengths and a carrier of photosensitizers to demonstrate in vivo PDT efficacy with the dual-photosensitizer approach.