Journal ArticleDOI
Transformation of olfactory representations in the Drosophila antennal lobe.
Reads0
Chats0
TLDR
Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferente, implicating lateral interactions within the antennal lobe.Abstract:
Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.read more
Citations
More filters
Journal ArticleDOI
Coding of Odors by a Receptor Repertoire
Elissa A. Hallem,John R. Carlson +1 more
TL;DR: A multidimensional "odor space" is constructed based on the responses of each individual receptor and it is found that the positions of odors depend on their chemical class, concentration, and molecular complexity.
Journal ArticleDOI
The molecular basis of odor coding in the Drosophila antenna.
TL;DR: A functional analysis of the odorant receptor repertoire in the Drosophila antenna finds that an individual receptor can mediate both excitatory and inhibitory responses to different odorants in the same cell, suggesting a model of odorant receptors transduction.
Journal ArticleDOI
Molecular, anatomical, and functional organization of the Drosophila olfactory system
TL;DR: These Or expression and ORN connectivity maps provide further insight into the molecular, anatomical, and functional organization of the Drosophila olfactory system and provide an essential resource for investigating how internal odor representations are generated and how they are further processed and transmitted to higher brain centers.
Journal ArticleDOI
Molecular Architecture of Smell and Taste in Drosophila
TL;DR: A critical review of the recent literature in smell and taste studies in Drosophila is provided to provide broad insights into the problem of sensory coding.
Journal ArticleDOI
A general mechanism for perceptual decision-making in the human brain
TL;DR: In this article, the authors used functional magnetic resonance imaging and a categorization task in which subjects decide whether an image presented is a face or a house to test whether a similar mechanism is also at work for more complex decisions in the human brain and where in the brain this computation might be performed.
References
More filters
Journal ArticleDOI
A spatial map of olfactory receptor expression in the Drosophila antenna.
TL;DR: A novel family of seven transmembrane domain proteins, encoded by 100 to 200 genes, that is likely to represent the family of Drosophila odorant receptors are identified and may ultimately afford a system to understand the mechanistic link between odor recognition and behavior.
Journal ArticleDOI
An olfactory sensory map in the fly brain
TL;DR: The "complete" repertoire of genes encoding the odorant receptors in Drosophila are isolated and employ these genes to provide a molecular description of the organization of the peripheral olfactory system.
Journal ArticleDOI
Mechanisms of olfactory discrimination : Converging evidence for common principles across phyla
TL;DR: The findings support the hypothesis that olfactory transduction and neural processing in the peripheral Olfactory pathway involve basic mechanisms that are universal across most species in most phyla.
Journal ArticleDOI
The Organization of the Chemosensory System in Drosophila Melanogaster: A Review
TL;DR: This review surveys the organization of the olfactory and gustatory systems in the imago and in the larva of Drosophila melanogaster, both at the sensory and the central level.
Journal ArticleDOI
Two-Photon Calcium Imaging Reveals an Odor-Evoked Map of Activity in the Fly Brain
TL;DR: A sensitive imaging system in the Drosophila brain that couples two-photon microscopy with the specific expression of the calcium-sensitive fluorescent protein, G-CaMP is developed, demonstrating that the response pattern of a given glomerulus is a function of the specificity of a single odorant receptor.