Molecular, anatomical, and functional organization of the Drosophila olfactory system
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TLDR
These Or expression and ORN connectivity maps provide further insight into the molecular, anatomical, and functional organization of the Drosophila olfactory system and provide an essential resource for investigating how internal odor representations are generated and how they are further processed and transmitted to higher brain centers.About:
This article is published in Current Biology.The article was published on 2005-09-06 and is currently open access. It has received 919 citations till now. The article focuses on the topics: Olfactory system & Antennal lobe.read more
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Odorant Reception in Insects: Roles of Receptors, Binding Proteins, and Degrading Enzymes
TL;DR: Although ORs in Drosophila melanogaster respond to multiple odorants and seem to work in combinatorial code involving both periphery and antennal lobes, reception of sex pheromones by moth ORs suggests that their labeled lines rely heavily on selectivity at the periphery.
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Coding of Odors by a Receptor Repertoire
Elissa A. Hallem,John R. Carlson +1 more
TL;DR: A multidimensional "odor space" is constructed based on the responses of each individual receptor and it is found that the positions of odors depend on their chemical class, concentration, and molecular complexity.
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Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila.
TL;DR: Conservation of IR/iGluR-related proteins in bacteria, plants, and animals suggests that this receptor family represents an evolutionarily ancient mechanism for sensing both internal and external chemical cues.
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Insect olfactory receptors are heteromeric ligand-gated ion channels
Koji Sato,Maurizio Pellegrino,Takao Nakagawa,Takao Nakagawa,Tatsuro Nakagawa,Leslie B. Vosshall,Kazushige Touhara +6 more
TL;DR: Evidence is provided that heteromeric insect ORs comprise a new class of ligand-activated non-selective cation channels and the fast response kinetics and OR-subunit-dependent K+ ion selectivity of the insect OR complex support the hypothesis that the complex between OR and Or83b itself confers channel activity.
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Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo
TL;DR: It is demonstrated that OR83b heterodimerizes with conventional ORs early in the endomembrane system in OSNs, couples these complexes to the conserved ciliary trafficking pathway, and is essential to maintain the OR/OR83b complex within the sensory cilia, where odor signal transduction occurs.
References
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A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more
TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.
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Combinatorial Receptor Codes for Odors
TL;DR: Using a combination of calcium imaging and single-cell RT-PCR to identify odorant receptors (ORs) for odorants with related structures but varied odors, it is found that one OR recognizes multiple odorants and that one odorant is recognized by multiple ORs, but that different odorants are recognized by different combinations of ORs.
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Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction.
Mattias C. Larsson,Ana Domingos,Walton D. Jones,M. Eugenia Chiappe,Hubert Amrein,Leslie B. Vosshall +5 more
TL;DR: The results support the second model of Or83b function, which encodes an atypical odorant receptor that plays an essential general role in olfaction and disrupts behavioral and electrophysiological responses to many odorants.
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A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes.
TL;DR: A simple non-radioactive in situ hybridization procedure for tissue sections and cultured cells using digoxigenin-labelled cRNA probes for the detection of various transcripts present at a wide range of expression levels in the central nervous system is developed.