Patent
Transgenic animals harboring app allele having swedish mutation
Lisa C. Mcconlogue,Jun Zhoa +1 more
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TLDR
In this paper, a transgene encoding an APP polypeptide comprising the Swedish mutation was proposed. But it was not suitable for transgenic non-human animals and transgenic mammalian cells.Abstract:
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.read more
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Prevention and treatment of amyloidogenic disease
TL;DR: In this article, the authors provide compositions and methods for treatment of amyloidogenic diseases, such as Alzheimer's disease, which entail administering an agent that induces a beneficial immune response against an Amyloid deposit in the patient.
Patent
Humanized antibodies that recognize beta amyloid peptide
Guriq Basi,Jose William Saldanha +1 more
TL;DR: In this article, the authors presented improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient, including humanized antibodies.
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Compounds and uses thereof in modulating amyloid beta
TL;DR: In this paper, novel compounds, compositions, and kits are provided for modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ level are also provided.
Patent
N,n'-substituted-1,3-diamino-2-hydroxypropane derivatives
James P. Beck,Larry Foster City Fang,John N Freskos,Andrea Gailunas,Roy Hom,Barbara Jagodzinska,Varghese John,Michel Maillard,John Mickelson,Lakshman Samala,Jennifer Sealy,Tenbrink Ruth E +11 more
TL;DR: In this paper, compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein, are shown to have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
References
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Manipulating the mouse embryo: A laboratory manual
TL;DR: Here are recorded the tech- niques for preparing, inserting and analysing DNA sequences, for retroviral infection of mice, for production and use of EC and EK cells as vehicles for engineered sequences and for nuclear transplantation - all against a background of the basic procedures required for pro- ducing and handling the em- bryos.
Journal ArticleDOI
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
George G. Glenner,Caine W. Wong +1 more
TL;DR: A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated and Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far.
Journal ArticleDOI
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Jie Kang,H. G. Lemaire,A. Unterbeck,J. M. Salbaum,Colin L. Masters,K.-H. Grzeschik,Gerd Multhaup,Konrad Beyreuther,Benno Müller-Hill +8 more
TL;DR: An apparently full-length complementary DNA clone coding for the A4 polypeptide is isolated and sequenced and suggests that the cerebral amyloid deposited in Alzheimer's disease and aged Down's syndrome is caused by aberrant catabolism of a cell-surface receptor.
Journal ArticleDOI
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
Alison Goate,Marie-Christine Chartier-Harlin,Michael Mullan,Jeremy P Brown,Fiona Crawford,Liana Fidani,L. Giuffra,Andrew Haynes,N.G. Irving,Louise James,R. Mant,Phillippa Newton,Karen Rooke,P Roques,Christopher Talbot,Margaret A. Pericak-Vance,Alien D. Roses,Robert Williamson,Martin N. Rossor,Michael John Owen,John Hardy +20 more
TL;DR: A locus segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21, close to the amyloid precursor protein (APP) gene as discussed by the authors, which suggests that some cases of AD could be caused by mutations in the APP gene.
Journal ArticleDOI
The scanning model for translation: an update.
TL;DR: The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation.
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