Transplanted dopaminergic neurons: more or less?
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This article is published in Nature Medicine.The article was published on 2001-05-01 and is currently open access. It has received 41 citations till now. The article focuses on the topics: Dopaminergic.read more
Citations
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Dyskinesia after fetal cell transplantation for parkinsonism: a PET study.
Yilong Ma,Yilong Ma,Andrew Feigin,Andrew Feigin,Vijay Dhawan,Vijay Dhawan,Masafumi Fukuda,Qiuhu Shi,Paul Greene,Robert E. Breeze,Stanley Fahn,Curt R. Freed,David Eidelberg,David Eidelberg +13 more
TL;DR: The findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for parkinsonism.
Journal ArticleDOI
Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells.
TL;DR: It is concluded that biodegradable polymer/progenitor cell composite grafts provide an effective means of increasing progenitor cell survival and overall yield when transplanting to sites within the central nervous system such as the retina.
Journal ArticleDOI
Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space
Sarah L. Tao,Conan Young,Stephen Redenti,Yiqin Zhang,Henry Klassen,Tejal A. Desai,Michael J. Young +6 more
TL;DR: Ultra-thin film PMMA scaffolds micromachined to contain through pores retain adherent RPCs to a considerably greater extent than unmachined versions during the transplantation process and can serve as a biocompatible substrate for cell delivery in vivo.
Journal ArticleDOI
Tauroursodeoxycholic Acid Improves the Survival and Function of Nigral Transplants in a Rat Model of Parkinson's Disease:
Wei-Ming Duan,Cecilia M P Rodrigures,Cecilia M P Rodrigures,Li-Ru Zhao,Clifford J. Steer,Walter C. Low +5 more
TL;DR: It is demonstrated that pretreatment of the cell suspension with TUDCA can reduce apoptosis and increase the survival of grafted cells, resulting in an improvement of behavioral recovery.
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Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke
Koichi Hara,Takao Yasuhara,Mina Maki,Noriyuki Matsukawa,Tadashi Masuda,Seong Jin Yu,Mohammed Ali,Guolong Yu,Lin Xu,Seung U. Kim,Seung U. Kim,David C. Hess,Cesar V. Borlongan,Cesar V. Borlongan +13 more
TL;DR: A proof-of-concept "retroviral" strategy is explored to further establish the post-mitotic status of NT2N cells by transfecting these cells with the transcription factor Nurr1, in addition to the standard treatment with retinoic acid and mitotic inhibitors.
References
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Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
Curt R. Freed,Paul Greene,Robert E. Breeze,Wei-Yann Tsai,William DuMouchel,Richard Kao,Sandra Dillon,Howard Winfield,Sharon Culver,John Q. Trojanowski,David Eidelberg,Stanley Fahn +11 more
TL;DR: After improvement in the first year, dystonia and dyskinesias recurred in 15 percent of the patients who received transplants, even after reduction or discontinuation of the dose of levodopa.
Transplantation of embryonic dopamine neurons for severe parkinson's disease
R. F Reed,P Aul E. G Reene,R Obert E. B Reeze,W Ei,W Illiam D U M Ouchel,R Ichard K Ao,W Infield,S Haron C Ulver,J Ohn Q. T Rojanowski,D Avid E Idelberg,S Tanley F Ahn +10 more
TL;DR: For example, in this paper, the authors randomly assigned 40 patients who were 34 to 75 years of age and had severe Parkinson's disease (mean duration, 14 years) to receive a transplant of nerve cells or undergo sham surgery; all were to be followed in a double-blind manner for one year.
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Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up
Olle Lindvall,S Rehncrona,Patrik Brundin,Björn Gustavii,Birger Åstedt,Hạkan Widner,Tore Lindholm,Anders Björklund,Klaus L. Leenders,John C. Rothwell,Richard S. J. Frackowiak,C. David Marsden,Bo Johnels,Göran Steg,Robert Freedman,Barry J. Hoffer,Åke Seiger,Marc Bygdeman,Ingrid Strömberg,Lars Olson +19 more