Journal ArticleDOI
Transport Protein Trafficking in Polarized Cells
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TLDR
This work has shown that transport proteins carry signals embedded within their structures that specify their subcellular distributions and endow them with the capacity to participate in regulated membrane trafficking processes.Abstract:
▪ Abstract In order to carry out their physiological functions, ion transport proteins must be targeted to the appropriate domains of cell membranes. Regulation of ion transport activity frequently involves the tightly controlled delivery of intracellular populations of transport proteins to the plasma membrane or the endocytic retrieval of transport proteins from the cell surface. Transport proteins carry signals embedded within their structures that specify their subcellular distributions and endow them with the capacity to participate in regulated membrane trafficking processes. Recently, a great deal has been learned about the biochemical nature of these signals, as well as about the cellular machinery that interprets them and acts upon their messages.read more
Citations
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Organization of vesicular trafficking in epithelia
TL;DR: Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.
Journal ArticleDOI
Efficacy and safety of once-weekly bortezomib in multiple myeloma patients
Sara Bringhen,Alessandra Larocca,Davide Rossi,Maide Cavalli,Mariella Genuardi,Roberto Ria,Silvia Gentili,Francesca Patriarca,Chiara Nozzoli,Anna Levi,Tommasina Guglielmelli,Giulia Benevolo,Vincenzo Callea,Vincenzo Rizzo,Clotilde Cangialosi,Pellegrino Musto,Luca De Rosa,Anna Marina Liberati,Mariella Grasso,Antonietta Falcone,Andrea Evangelista,Michele Cavo,Gianluca Gaidano,Mario Boccadoro,Antonio Palumbo +24 more
TL;DR: The protocol was amended and patients in both arms received once-weekly instead of the initial twice-weekly bortezomib infusions to decrease neurologic toxicities, and an improvement in safety did not appear to affect efficacy.
Journal ArticleDOI
Trafficking of the copper-ATPases, ATP7A and ATP7B: Role in copper homeostasis
TL;DR: An update on the current state of the understanding of the localization and trafficking properties of the copper-ATPases in cells and tissues, the molecular signals and posttranslational interactions that govern their trafficking activities, and the cellular basis for the clinical phenotypes associated with disease-causing mutations are provided.
Journal ArticleDOI
Polarized sorting in epithelial cells: raft clustering and the biogenesis of the apical membrane
Sebastian Schuck,Kai Simons +1 more
TL;DR: The clustering of lipid rafts through the oligomerization of raft components could be utilized for segregating apical from basolateral cargo and for the generation of intracellular transport carriers.
Journal ArticleDOI
Apical trafficking in epithelial cells: signals, clusters and motors.
TL;DR: A model in which clustering is required to recruit apical trafficking machineries is discussed and it is suggested that polarized trafficking and their epithelial-specific variations will help understand how epithelial functional diversity is generated and the pathogenesis of many human diseases.
References
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Journal ArticleDOI
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI
Molecular Mechanisms of Human Hypertension
TL;DR: Supported in part by a Specialized Center of Research in Hypertension and NIH K08 awards (to A. G. and D. S. G.) and a grant from the Howard Hughes Medical Institute.
Journal ArticleDOI
PDZ Domains and the Organization of Supramolecular Complexes
Morgan Sheng,Carlo Sala +1 more
TL;DR: PDZ domains are modular protein interaction domains that bind in a sequence-specific fashion to short C-terminal peptides or internal peptides that fold in a beta-finger.
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The vacuolar (H+)-ATPases--nature's most versatile proton pumps.
Tsuyoshi Nishi,Michael Forgac +1 more
TL;DR: The pH of intracellular compartments in eukaryotic cells is a carefully controlled parameter that affects many cellular processes, including intrACEllular membrane transport, prohormone processing and transport of neurotransmitters, as well as the entry of many viruses into cells.
Journal ArticleDOI
Regulated transport of the glucose transporter GLUT4
TL;DR: In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from an intracellular location to the cell surface, where it facilitates the reduction of plasma glucose levels.