Journal ArticleDOI
Trypanocidal activity and redox potential of heterocyclic- and 2-hydroxy-naphthoquinones
Marília O. F. Goulart,Carlos L. Zani,Josealdo Tonholo,Luciano R. Freitas,Fabiane C. de Abreu,Alaíde Braga de Oliveira,Délio S. Raslan,Sérgia M. Starling,Egler Chiari +8 more
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TLDR
In this article, a series of quinones were tested in vitro with trypomastigotes of Trypanosoma cruzi and their first cathodic potentials (Epcl) measured by cyclic voltammetry.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 1997-08-05. It has received 115 citations till now.read more
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Journal ArticleDOI
Electrochemical Approach to the Mechanistic Study of Proton-Coupled Electron Transfer
TL;DR: The analysis of such stepwise mechanisms both in aprotic media and in water is reviewed, with particular recent emphasis on electrochemical and theoretical approaches to proton-coupled electron transfer processes.
Journal ArticleDOI
The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I
Thomas J. Schmidt,Sami A. Khalid,Alvaro J. Romanha,T. Ma. Alves,Maique W. Biavatti,Reto Brun,FB Da Costa,S. L. De Castro,Vitor F. Ferreira,M. V. G. de Lacerda,João Henrique G. Lago,Leonor L. Leon,Norberto Peporine Lopes,R. C. das Neves Amorim,Michael Niehues,Ifedayo Victor Ogungbe,Adrian Martin Pohlit,Marcus Tullius Scotti,William N. Setzer,M. de N. C. Soeiro,M. Steindel,Andre G. Tempone +21 more
TL;DR: The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.
Journal ArticleDOI
Potent antitumor activity of synthetic 1,2-Naphthoquinones and 1,4-Naphthoquinones.
Ngampong Kongkathip,Boonsong Kongkathip,Pongpun Siripong,Chak Sangma,Suwaporn Luangkamin,Momad Niyomdecha,Suppachai Pattanapa,Suratsawadee Piyaviriyagul,Palangpon Kongsaeree +8 more
TL;DR: Six 1,4-naphthoquinones derivatives fused with pyran ring and furan ring were synthesized and they showed less cytotoxicity or inactive to the cancer cell lines and compound 13 had significant cytot toxicity against HeLa cell line while it showed no toxic to vero cell.
Journal ArticleDOI
Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds
Elizabeth A. Hillard,Fabiane C. de Abreu,Danielle Cristhina Melo Ferreira,Gérard Jaouen,Marília O. F. Goulart,Christian Amatore +5 more
TL;DR: This review article summarizes recent applications of electrochemical techniques to redox-active drug development and mechanistic studies and includes a general introduction to the use of electrochemistry in biology, with a focus on how electrochemical can uniquely provide both kinetic and thermodynamic information.
References
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Book
Advances in pharmacology and chemotherapy
TL;DR: Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics, with emphasis on the molecular basis of drug action, both applied and experimental.
Journal Article
Toxic effects of nifurtimox and benznidazole, two drugs used against American trypanosomiasis (Chagas' disease).
Castro Ja,Diaz de Toranzo Eg +1 more
TL;DR: Signs of testicular and ovarian injury were reported for both Nfx and Bz, the effects of Bz being in general less intense than those of Nfx, and both drugs evidenced mutagenicity.
Journal ArticleDOI
In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi
J. N. Lopes,F. S. Cruz,R. Docampo,M. E. Vasconcellos,M. C. R. Sampaio,A. V. Pinto,B. Gilbert +6 more
TL;DR: The toxic effect of lapachol, beta-lapachone and several 1,2-naphthoquinone derivatives on the growth, viability and infectivity of Trypanosoma cruzi were compared and it is suggested that beta- Lapachol and the other compounds can be inactivated either by reduction in the presence of oxyhaemoglobin or by interaction with serum proteins.
Journal ArticleDOI
One- and two-electron reduction of hydroxy-1,4-naphthoquinones and hydroxy-9,10-anthraquinones. The role of internal hydrogen bonding and its bearing on the redox chemistry of the anthracycline antitumour quinones.
TL;DR: Measurements on the corresponding methoxy- and acetoxyquinones indicate that internal hydrogen bonding in the alpha-hydroxyquinones makes a major contribution to stabilisation of the semiquinone, probably as a result of increased delocalisation due to exchange of the hydroxy hydrogen between the two neighbouring oxygen atoms.