Journal ArticleDOI
Tularemia as a Biological Weapon.Medical and Public Health Management
David T. Dennis,Thomas V. Inglesby,Donald A. Henderson,John G. Bartlett,Michael S. Ascher,Edward M. Eitzen,Anne D. Fine,Arthur M. Friedlander,Jerome Hauer,Marcelle Layton,Scott R. Lillibridge,Joseph E. McDade,Michael T. Osterholm,Tara O'Toole,Gerald W. Parker,Trish M. Perl,Philip K. Russell,Kevin Tonat +17 more
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TLDR
The Working Group on Civilian Biodefense has developed consensus-based recommendations for measures to be taken by medical and public health professionals if tularemia is used as a biological weapon against a civilian population.Abstract:
ObjectiveThe Working Group on Civilian Biodefense has developed consensus-based
recommendations for measures to be taken by medical and public health professionals
if tularemia is used as a biological weapon against a civilian population.ParticipantsThe working group included 25 representatives from academic medical
centers, civilian and military governmental agencies, and other public health
and emergency management institutions and agencies.EvidenceMEDLINE databases were searched from January 1966 to October 2000, using
the Medical Subject Headings Francisella tularensis, Pasteurella tularensis, biological weapon, biological terrorism, bioterrorism, biological warfare, and biowarfare. Review of these references led to identification
of relevant materials published prior to 1966. In addition, participants identified
other references and sources.Consensus ProcessThree formal drafts of the statement that synthesized information obtained
in the formal evidence-gathering process were reviewed by members of the working
group. Consensus was achieved on the final draft.ConclusionsA weapon using airborne tularemia would likely result 3 to 5 days later
in an outbreak of acute, undifferentiated febrile illness with incipient pneumonia,
pleuritis, and hilar lymphadenopathy. Specific epidemiological, clinical,
and microbiological findings should lead to early suspicion of intentional
tularemia in an alert health system; laboratory confirmation of agent could
be delayed. Without treatment, the clinical course could progress to respiratory
failure, shock, and death. Prompt treatment with streptomycin, gentamicin,
doxycycline, or ciprofloxacin is recommended. Prophylactic use of doxycycline
or ciprofloxacin may be useful in the early postexposure period.read more
Citations
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Journal ArticleDOI
2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings.
TL;DR: The ability of hospital ventilation systems to filter Aspergillus and other fungi following a building implosion and the impact of bedside design and furnishing on nosocomial infections are investigated.
Guideline for isolation precautions: preventing transmission of infectious agents in healthcare settings 2007.
TL;DR: The ability of hospital ventilation systems to filter Aspergillus and other fungi following a building implosion and the impact of bedside design and furnishing on nosocomial infections are investigated.
Journal ArticleDOI
Update of Practice Guidelines for the Management of Community-Acquired Pneumonia in Immunocompetent Adults
Lionel A. Mandell,John G. Bartlett,Scott F. Dowell,Thomas M. File,Daniel M. Musher,Cynthia G. Whitney +5 more
TL;DR: It was decided that all of the information dealing with the initial empiric treatment regimens should be in tabular format with footnotes, and the topics selected for updating have been organized according to the headings used in the August 2000 CAP guidelines.
Journal ArticleDOI
Public health assessment of potential biological terrorism agents.
TL;DR: This report outlines the overall selection and prioritization process used to determine the biological agents for public health preparedness activities and helps facilitate coordinated planning efforts among federal agencies, state and local emergency response and public health agencies, and the medical community.
Journal ArticleDOI
Hemorrhagic Fever Viruses as Biological Weapons: Medical and Public Health Management
Luciana Borio,Thomas V. Inglesby,Clarence J. Peters,Alan L. Schmaljohn,James M. Hughes,Peter B. Jahrling,Thomas G. Ksiazek,Karl M. Johnson,Andrea Meyerhoff,Tara O'Toole,Michael S. Ascher,John G. Bartlett,Joel G. Breman,Edward M. Eitzen,Margaret Hamburg,Jerry Hauer,Donald A. Henderson,Richard T. Johnson,Gigi Kwik,Marci Layton,Scott R. Lillibridge,Gary J. Nabel,Michael T. Osterholm,Trish M. Perl,Philip K. Russell,Kevin Tonat +25 more
TL;DR: Weapons disseminating a number of HFVs could cause an outbreak of an undifferentiated febrile illness 2 to 21 days later, associated with clinical manifestations that could include rash, hemorrhagic diathesis, and shock.
References
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Book
Principles and Practice of Infectious Diseases
TL;DR: This updated and expanded edition now offers 297 chapters that cover the basic principles of diagnosis and management, major clinical syndromes, all important pathogenic microbes and the diseases they cause, plus a number of specialised topics useful to the practitioner.
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Manual of Clinical Microbiology
TL;DR: The role of the Clinical Microbiology Laboratory in Nosocomial and Community Infections and Antimicrobial Agents and Susceptibility Tests, Quality Control, Media, Reagents and Stains is examined.
Journal ArticleDOI
Report of the Committee on Infectious Diseases
TL;DR: The Report of the Committee on Infectious Disease (ie, the so-called Red Book) is a source of essential information on the prevention, diagnosis, and treatment of pediatric infectious diseases.
Journal ArticleDOI
Botulinum Toxin as a Biological Weapon: Medical and Public Health Management
Stephen S. Arnon,Robert Schechter,Thomas V. Inglesby,Donald A. Henderson,John G. Bartlett,Michael S. Ascher,Edward M. Eitzen,Anne D. Fine,Jerome Hauer,Marcelle Layton,Scott R. Lillibridge,Michael T. Osterholm,Tara O'Toole,Gerald W. Parker,Trish M. Perl,Philip K. Russell,David L. Swerdlow,Kevin Tonat +17 more
TL;DR: People potentially exposed to botulinum toxin should be closely observed, and those with signs of botulism require prompt treatment with antitoxin and supportive care that may include assisted ventilation for weeks or months.
Journal ArticleDOI
Smallpox as a Biological Weapon Medical and Public Health Management
Donald A. Henderson,Thomas V. Inglesby,Thomas V. Inglesby,John G. Bartlett,John G. Bartlett,Michael S. Ascher,Edward M. Eitzen,Peter B. Jahrling,Jerome Hauer,Marcelle Layton,Joseph E. McDade,Michael T. Osterholm,Tara O'Toole,Gerald W. Parker,Trish M. Perl,Philip K. Russell,Kevin Tonat +16 more
TL;DR: In this paper, the Working Group onCivilian Biodefense has proposed a set of guidelines for the use of bio-medical data for defense against cyber-attacks against the US government.
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