Journal ArticleDOI
Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression.
Rui Wang,Jie Zhang,Sufeng Chen,Meng Lu,Xiaoyang Luo,Shihua Yao,Shilei Liu,Ying Qin,Haiquan Chen +8 more
TLDR
It was demonstrated that those up-regulated genes in TAMs contributed to suitable microenvironments for lung cancer invasion and metastasis, and may be useful in developing novel therapeutic strategies to prevent lung cancer progression.About:
This article is published in Lung Cancer.The article was published on 2011-11-01. It has received 160 citations till now. The article focuses on the topics: Cancer & Lung cancer.read more
Citations
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Tumor associated macrophages and neutrophils in cancer.
Maria Rosaria Galdiero,Eduardo Bonavita,Isabella Barajon,Cecilia Garlanda,Alberto Mantovani,Sébastien Jaillon +5 more
TL;DR: Macrophages and neutrophils are both integrated in the regulation of the innate and adaptive immune responses in various inflammatory situations, including cancer.
Journal ArticleDOI
Tumor-associated macrophages: an accomplice in solid tumor progression
TL;DR: The role of TAMs in promoting tumor growth, enhancing cancer cells resistance to chemotherapy and radiotherapy, promoting tumor angiogenesis, inducing tumor migration and invasion and metastasis, activating immunosuppression is focused on.
Journal ArticleDOI
Much More than M1 and M2 Macrophages, There are also CD169(+) and TCR(+) Macrophages.
TL;DR: The refined characterization of the macrophage subpopulations can be useful in designing new strategies, supplementing those already established for the treatment of diseases using macrophages as a therapeutic target.
Journal ArticleDOI
Tumor associated macrophages and neutrophils in tumor progression
TL;DR: Evidence is provided that also neutrophils can be driven towards distinct phenotypes in response to microenvironmental signals, and the identification of mechanisms and molecules associated with macrophage and neutrophil plasticity and polarized activation provides a basis for new diagnostic and therapeutic strategies.
Journal Article
Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer
TL;DR: The current understanding of how the tumor microenvironment takes advantage of macrophage plasticity to mold an immunosuppressive population, the phenotypic heterogeneity of TAMs, and their link to prognosis in human lung cancer are summarized.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
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The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
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Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates.
Christa Heussen,Eugene B. Dowdle +1 more
TL;DR: A new technique is described for the electrophoretic analysis of plasminogen activators in sodium dodecyl sulfate-polyacrylamide gels containing copolymerized pl asminogen and gelatin, which can be used to detect as little as 1 mU of urokinase and effectively distinguishes between melanoma- and u rokinase-type plasmineg activators.
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Matrix metalloproteinases and tumor metastasis
TL;DR: The major pieces of evidence that are most compelling and clearly determine the role and involvement of MMPs in the metastatic cascade are provided by molecular genetic studies employing knock-out or transgenic animals and tumor cell lines, modified to overexpress or downregulate a specific MMP.
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