Journal ArticleDOI
Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects.
Lingtong Meng,Yali Cheng,Xiaoning Tong,Shaoju Gan,Yawen Ding,Yu Zhang,Chao Wang,Lei Xu,Yishen Zhu,Jinhui Wu,Yiqiao Hu,Ahu Yuan +11 more
TLDR
A reactive oxygen species (ROS) responsive nanoplatform is reported to successfully add up tumor oxygenation and HIF-1 functional inhibition and achieve synergistically the optimal inhibition of tumor growth.Abstract:
Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced radiation resistance, recent studies have described nanosystems to improve tumor oxygenation for immobilizing DNA damage and simultaneously initiate oxygen-dependent HIF-1α degradation. However, HIF-1α degradation is incomplete during tumor oxygenation treatment alone. Therefore, tumor oxygenation combined with residual HIF-1 functional inhibition is crucial to optimizing therapeutic outcomes of radiotherapy. Here, a reactive oxygen species (ROS) responsive nanoplatform is reported to successfully add up tumor oxygenation and HIF-1 functional inhibition. This ROS responsive nanoplatform, based on manganese dioxide (MnO2) nanoparticles, delivers the HIF-1 inhibitor acriflavine and other hydrophilic cationic drugs to tumor tissues. After reacting with overexpressed hydrogen peroxide (H2O2) within tumor tissues, Mn2+ and oxygen molecules are released for magnetic resonance imaging and tumor oxygenation, respectively. Cooperating with the HIF-1 functional inhibition, the expression of tumor invasion-related signaling molecules (VEGF, MMP-9) is obviously decreased to reduce the risk of metastasis. Furthermore, the nanoplatform could relieve T-cell exhaustion via downregulation of PD-L1, whose effects are similar to the checkpoint inhibitor PD-L1 antibody, and subsequently activates tumor-specific immune responses against abscopal tumors. These therapeutic benefits including increased X-ray-induced damage, downregulated resistance, and T-cell exhaustion related proteins expression achieved synergistically the optimal inhibition of tumor growth. Overall, this designed ROS responsive nanoplatform is of great potential in the sensitization of radiation for combating primary and metastatic tumors.read more
Citations
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Journal ArticleDOI
Reactive Oxygen Species (ROS)-Based Nanomedicine.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: In this article, the intrinsic biochemical properties of reactive oxygen species (ROS) underlie the mechanisms that regulate various physiological functions of living organisms, and they play an essential role in regulating various physiological function.
Journal ArticleDOI
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
TL;DR: The representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced.
Journal ArticleDOI
Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors.
TL;DR: A biomimetic hybrid nanozyme is reported which integrates natural enzyme glucose oxidase with nanozyme manganese dioxide by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx and would further facilitate the development of biological nanozymes for cancer treatment.
Journal ArticleDOI
Regulation of PD-L1 expression in the tumor microenvironment.
TL;DR: In this paper, the authors focused on PD-L1 regulators at the levels of transcription, post-transcription, and post-translation, and discussed potential applications of these laboratory findings in the clinic.
Journal ArticleDOI
X-ray-activated nanosystems for theranostic applications
TL;DR: This review systematically describes the interaction mechanisms between X-rays and nanosystems, and provides an overview of X-ray-sensitive materials and the recent progress on X- Ray-activated nanosSystems for cancer-associated theranostic applications.
References
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Journal ArticleDOI
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Journal ArticleDOI
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
Thomas Powles,Joseph Paul Eder,Gregg Fine,Fadi Braiteh,Yohann Loriot,Cristina Cruz,Joaquim Bellmunt,Howard A. Burris,Daniel P. Petrylak,Siew-leng Melinda Teng,Xiaodong Shen,Zachary Boyd,Priti S. Hegde,Daniel S. Chen,Nicholas J. Vogelzang +14 more
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Journal ArticleDOI
Matrix metalloproteinases and tumor metastasis
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