Journal ArticleDOI
Two different fucosylated chondroitin sulfates: Structural elucidation, stimulating hematopoiesis and immune-enhancing effects.
Qingfeng Niu,Guoyun Li,Chao Li,Qinying Li,Jia Li,Chanjuan Liu,Lin Pan,Shijie Li,Chao Cai,Jiejie Hao,Guangli Yu +10 more
TLDR
The results showed that FCShp and FCSht had beneficial effects on hematopoietic function recovery in CTX-induced bone marrow suppression mice, and provided basis for developing the drugs to reduce side effects of chemotherapy.About:
This article is published in Carbohydrate Polymers.The article was published on 2020-02-15. It has received 18 citations till now. The article focuses on the topics: Chondroitin & Chondroitin sulfate.read more
Citations
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Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection.
Rohini Dwivedi,Priyanka Samanta,Poonam Sharma,Fuming Zhang,Sushil K. Mishra,Pavel Kucheryavy,Seon Beom Kim,AyoOluwa O. Aderibigbe,Robert J. Linhardt,Ritesh Tandon,Robert J. Doerksen,Vitor H. Pomin +11 more
TL;DR: In this paper, a new fucosylated chondroitin sulfate (FucCS) from the sea cucumber Pentacta pygmaea was isolated and structurally characterized by NMR.
Journal ArticleDOI
Metabolic engineering for production of functional polysaccharides.
TL;DR: With increasing knowledge of bottleneck enzymes and fluxes, it will be possible to enable a sustainable microbial production of high value polysaccharides and tailor artificial polymers towards specific applications.
Journal ArticleDOI
Low-molecular-weight fucosylated glycosaminoglycan and its oligosaccharides from sea cucumber as novel anticoagulants: A review
Hong Li,Qingxia Yuan,Kunling Lv,Haiqiong Ma,Chenghai Gao,Yonghong Liu,Siyuan Zhang,Longyan Zhao +7 more
TL;DR: This review presents recent findings regarding the preparation, structural analysis, pharmacological activity, and structure-activity relationships of LFG and its derived oligosaccharides, so as to provide a reference for the development of new anticoagulants with low side effects.
Journal ArticleDOI
Structural elucidation and antidiabetic activity of fucosylated chondroitin sulfate from sea cucumber Stichopus japonicas.
TL;DR: In this paper, a fucosylated chondroitin sulfate was isolated from the body wall of sea cucumber Stichopus japonicus (FCSsj), whose structure was characterized by NMR spectroscopy and HILIC-FTMS.
Journal ArticleDOI
Application of nonthermal processing technologies in extracting and modifying polysaccharides: A critical review.
Xiaolan Li,Zhi-Hong Zhang,Xianghui Qi,Lin Li,Jie Zhu,Charles S. Brennan,Jing-Kun Yan,Jing-Kun Yan +7 more
TL;DR: In this article, a comprehensive summary about the extraction and modification of polysaccharides by nonthermal technologies, including ultrasound, high hydrostatic pressure, pulsed electric fields, and cold plasma, was provided.
References
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Journal ArticleDOI
A note on the determination of the ester sulphate content of sulphated polysaccharides.
K S Dodgson,R G Price +1 more
Journal ArticleDOI
Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm SULFATED FUCOSE BRANCHES ON THE POLYSACCHARIDE ACCOUNT FOR ITS HIGH ANTICOAGULANT ACTION
Paulo A.S. Mourão,Mariana S. Pereira,Mauro S. G. Pavão,Barbara Mulloy,Douglas M. Tollefsen,Marie-Christine Mowinckel,Ulrich Abildgaard +6 more
TL;DR: Assays with purified reagents show that the fucosylated chondroitin sulfate can potentiate the thrombin inhibition activity of both antithrombin and heparin cofactor II.
Journal ArticleDOI
Comparison of structures and anticoagulant activities of fucosylated chondroitin sulfates from different sea cucumbers
TL;DR: Anticoagulant activities of the four fCSs can be attributed to the difference in sulfation pattern of the fucose branch of the chondroitin sulfate, and 2,4- O -disulfation is important for anticoagULant activity.
Journal ArticleDOI
Isolation and partial characterization of fucan sulfates from the body wall of sea cucumber Stichopus japonicus and their ability to inhibit osteoclastogenesis.
Yutaka Kariya,Barbara Mulloy,Kyoko Imai,Akihiro Tominaga,Takuji Kaneko,Akira Asari,Kiyoshi Suzuki,Hiroyuki Masuda,Mamoru Kyogashima,Tadashi Ishii +9 more
TL;DR: Results suggest that types A and B fucan sulfate from sea cucumber are potent inhibitors of osteoclastogenesis.
Journal ArticleDOI
Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase.
Mingyi Wu,Dandan Wen,Na Gao,Chuang Xiao,Lian Yang,Li Xu,Wu Lian,Wenlie Peng,Jianmin Jiang,Jinhua Zhao +9 more
TL;DR: In vitro and in vivo studies suggested that fractions of 6-12 kDa may be very promising compounds as putative selective intrinsic Xase inhibitors with antithrombotic action, but without the consequences of major bleeding and factor XII activation.