Journal ArticleDOI
Two-photon-excited near-infrared emissive carbon dots as multifunctional agents for fluorescence imaging and photothermal therapy
Minhuan Lan,Shaojing Zhao,Zhenyu Zhang,Li Yan,Liang Guo,Guangle Niu,Jinfeng Zhang,Junfang Zhao,Hongyan Zhang,Pengfei Wang,Guangyu Zhu,Chun-Sing Lee,Wenjun Zhang +12 more
TLDR
In vitro and in vivo tests suggested that CDs can function as new multifunctional phototheranostic agents for the TPE fluorescence imaging and photothermal therapy of cancer cells.Abstract:
C dots (CDs) have shown great potential in bioimaging and phototherapy. However, it is challenging to manipulate their fluorescent properties and therapeutic efficacy to satisfy the requirements for clinic applications. In this study, we prepared S, Se-codoped CDs via a hydrothermal method and demonstrated that the doping resulted in excitation wavelength-independent near-infrared (NIR) emissions of the CDs, with peaks at 731 and 820 nm. Significantly, the CDs exhibited a photothermal conversion efficiency of ~58.2%, which is the highest reported value for C nanostructures and is comparable to that of Au nanostructures. Moreover, the CDs had a large two-photon absorption cross section (~30,045 GM), which allowed NIR emissions and the photothermal conversion of the CDs through the two-photon excitation (TPE) mechanism. In vitro and in vivo tests suggested that CDs can function as new multifunctional phototheranostic agents for the TPE fluorescence imaging and photothermal therapy of cancer cells.read more
Citations
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Journal ArticleDOI
Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications
Junjun Liu,Rui Li,Bai Yang +2 more
TL;DR: This Outlook comprehensively summarize the classification of CDs based on the analysis of their formation mechanism, micro-/nanostructure and property features, and describe their synthetic methods and optical properties including strong absorption, photoluminescence, and phosphorescence.
Journal ArticleDOI
Photosensitizers for Photodynamic Therapy
TL;DR: The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted and the approaches that combine PDT with other therapeutics and the targeted delivery in cancer cells or tumor tissue are introduced.
Journal ArticleDOI
Near-Infrared Excitation/Emission and Multiphoton-Induced Fluorescence of Carbon Dots.
Di Li,Pengtao Jing,Lihuan Sun,Yang An,Xinyan Shan,Xinghua Lu,Ding Zhou,Dong Han,Dezhen Shen,Yuechen Zhai,Songnan Qu,Radek Zbořil,Andrey L. Rogach,Andrey L. Rogach +13 more
TL;DR: This study represents the realization of both NIR-I excitation and emission as well as two-photon- and three- photon-induced fluorescence of CDs excited in an Nir-II window, and provides a rational design approach for construction and clinical applications of CD-based NIR imaging agents.
Journal ArticleDOI
One-Step Hydrothermal Synthesis of Nitrogen-Doped Conjugated Carbonized Polymer Dots with 31% Efficient Red Emission for In Vivo Imaging.
TL;DR: A green, facile hydrothermal synthesis of highly efficient red emissive nitrogen-doped carbonized polymer dots (CPDs) with optimal emission at around 630 nm are reported, demonstrating that most CPDs and their metabolites are not only excreted in urine but also excrete by hepatobiliary system in a rapid manner.
Journal ArticleDOI
A Mini Review on Carbon Quantum Dots: Preparation, Properties, and Electrocatalytic Application.
TL;DR: The primary advances of CQDs in the synthetic methods, excellent physical and electronic properties, and application in electrocatalysis, including oxygen reduction reaction (ORR), oxygen evolution reaction (OER), hydrogen evolution reduction (HER), and CO2 reduction Reaction (CO2RR).
References
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Journal ArticleDOI
Luminescent Carbon Nanodots: Emergent Nanolights
Sheila N. Baker,Gary A. Baker +1 more
TL;DR: This Review summarize recent advances in the synthesis and characterization of C-dots and speculate on their future and discuss potential developments for their use in energy conversion/storage, bioimaging, drug delivery, sensors, diagnostics, and composites.
Journal ArticleDOI
Carbon quantum dots and their applications
TL;DR: The progress in the research and development of CQDs is reviewed with an emphasis on their synthesis, functionalization and technical applications along with some discussion on challenges and perspectives in this exciting and promising field.
Book
Modern Molecular Photochemistry
TL;DR: In this paper, the authors bring students up to date with the advances in this field -the development of the theory of photoreactions, the utilization of photoresceptors in synthetic sequences, and the advancement of powerful laser techniques to study the mechanisms of the photoreaction.
Journal ArticleDOI
Nanoparticles in photodynamic therapy.
TL;DR: This paper presents a meta-modelling study of the response of the immune system to chemotherapy and its applications in the context of central nervous system disorders.
Journal ArticleDOI
The energy gap law for radiationless transitions in large molecules
Robert Englman,Joshua Jortner +1 more
TL;DR: In this article, a unified treatment of non-radiative decay processes in large molecules which involve either electronic relaxation between two electronic states or unimolecular rearrangeme(s) is presented.