Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals.
Nilay Shah,Muhammad Ahmad Maqbool,Yousra Yahia,Amal Zine El Aabidine,Cyril Esnault,Ignasi Forné,Tim-Michael Decker,David C. Martin,Roland Schüller,Stefan Krebs,Helmut Blum,Axel Imhof,Dirk Eick,Jean-Christophe Andrau +13 more
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TLDR
It is concluded that tyrosine1 residues of the CTD control termination of transcription by Pol II and Pol II loading at enhancers and maturation of snRNAs are altered in the YFFF context genome-wide.About:
This article is published in Molecular Cell.The article was published on 2018-01-04 and is currently open access. It has received 65 citations till now. The article focuses on the topics: RNA polymerase II & Promoter.read more
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Transcription Elongation Can Affect Genome 3D Structure.
Sven Heinz,Lorane Texari,Michael G.B. Hayes,Matthew Urbanowski,Max W. Chang,Ninvita Givarkes,Alexander Rialdi,Kris M. White,Randy A. Albrecht,Lars Pache,Ivan Marazzi,Adolfo García-Sastre,Megan L. Shaw,Christopher Benner +13 more
TL;DR: The data indicate that transcription elongation by RNA polymerase II remodels genome 3D architecture and affects cohesin-mediated chromatin contacts within gene bodies.
Journal ArticleDOI
Enhancer RNAs are an important regulatory layer of the epigenome.
TL;DR: Recent insights into the biogenesis of eRNAs and the mechanisms underlying their multifaceted functions are considered and how these findings could inform future investigations into enhancer transcription and eRNA function are considered.
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Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism.
Michael A. Cortazar,Ryan M. Sheridan,Benjamin Erickson,Nova Fong,Kira Glover-Cutter,Kristopher W. Brannan,David Bentley +6 more
TL;DR: A model for termination, the "sitting duck torpedo" mechanism, where poly(A) site-dependent deceleration caused by PNUTS-PP1 and Spt5 dephosphorylation is required to convert Pol II into a viable target for the Xrn2 terminator exonuclease.
Journal ArticleDOI
The Integrator complex cleaves nascent mRNAs to attenuate transcription.
Deirdre C. Tatomer,Nathan D. Elrod,Dongming Liang,Mei Sheng Xiao,Jeffrey Z. Jiang,Michael Jonathan,Kai Lieh Huang,Eric J. Wagner,Sara Cherry,Jeremy E. Wilusz +9 more
TL;DR: The results suggest that attenuation via Integrator cleavage limits production of many full-length mRNAs, allowing precise control of transcription outputs.
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Cellular consequences of arginine methylation
TL;DR: This review highlights discoveries illuminating how arginine methylation affects genome integrity, gene transcription, mRNA splicing and mRNP biology, protein translation and stability, and phase separation.
References
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Differential expression analysis for sequence count data.
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TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
Daehwan Kim,Daehwan Kim,Geo Pertea,Cole Trapnell,Cole Trapnell,Harold Pimentel,Kelley Ryan Matthew,Steven L. Salzberg,Steven L. Salzberg +8 more
TL;DR: TopHat2 is described, which incorporates many significant enhancements to TopHat, and combines the ability to identify novel splice sites with direct mapping to known transcripts, producing sensitive and accurate alignments, even for highly repetitive genomes or in the presence of pseudogenes.
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Differential expression analysis for sequence count data
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