Journal ArticleDOI
Ultra-performance liquid chromatography–tandem mass spectrometric method for the determination of strychnine and brucine in mice plasma
TLDR
A selective, simple and efficient method-ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for determination of two toxic alkaloids, namely strychnine and brucine in mice plasma.About:
This article is published in Journal of Chromatography B.The article was published on 2011-09-15. It has received 23 citations till now. The article focuses on the topics: Brucine & High-performance liquid chromatography.read more
Citations
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A study of Semen Strychni-induced renal injury and herb-herb interaction of Radix Glycyrrhizae extract and/or Rhizoma Ligustici extract on the comparative toxicokinetics of strychnine and brucine in rats.
Liqiang Gu,Xiaofan Wang,Zhenzhen Liu,Ping Ju,Lunhui Zhang,Yuanyuan Zhang,Bingjie Ma,Kaishun Bi,Xiaohui Chen +8 more
TL;DR: Results indicated that high dose of Semen Strychni might induce renal injury and Radix Glycyrrhizae and Rhizoma Ligustici might work together and have effects on the elimination of strychnine and brucine.
Journal ArticleDOI
Recent developments in the field of the determination of constituents of TCMs in body fluids of animals and human.
TL;DR: The present review summarizes the current extraction techniques, chromatographic separation and spectroscopic (especially mass spectrometric) analysis methods and new trends on the analysis of bioactive components and metabolites of TCMs in biological fluids.
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Sensitive detection of brucine an anti-metastatic drug for hepatocellular carcinoma at carbon nanotubes - nafion composite based biosensor.
TL;DR: The method was successfully applied for the detection of brucine in traditional pharmaceutical formulations and demonstrated by the analysis of the alkaloid in human serum and urine samples exhibiting considerable potential as a diagnostic tool.
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Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components
TL;DR: Biochemical analysis results indicated that TGP could ameliorate the oxidative stress status caused by SAs and showed a pre-protective effect against neurotoxicity by reducing the absorption of toxic alkaloids into the brain.
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Determination of 12 potential nephrotoxicity biomarkers in rat serum and urine by liquid chromatography with mass spectrometry and its application to renal failure induced by Semen Strychni
TL;DR: Results showed that Guanidinosuccinic acid, guanidinoacetic acid, 3-indoxyl sulfate, and indole-3-acetic Acid were more sensitive than the conventional renal function markers in evaluating the therapeutic role of Radix Glycyrrhizae extract on Semen Strychni-induced renal failure.
References
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About the toxicity of some Strychnos species and their alkaloids.
TL;DR: By their nature, poisons such as strychnine and curare affect the functioning of the victim's body; this also means that they have been an important source of pharmacological tools and medicines all over the world.
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Anti-proliferative and cytotoxic effects of Strychnos nux-vomica root extract on human multiple myeloma cell line - RPMI 8226.
TL;DR: The morphological assessment of SN-extract treated cells showed significant features associated with apoptosis, and anti-proliferative and cytotoxic activity could be due to the alkaloids strychnine and brucine, which have been identified by LC-mass spectral analysis of the SN- Extract in comparison to the reference standards analyzed under identical conditions.
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Case report: Survival after deliberate strychnine self-poisoning, with toxicokinetic data.
TL;DR: Strychnine poisoning presents with classical features, and with early diagnosis and supportive management, the patient can survive, and the initial serum concentration is the highest reported concentration in a patient who has survived.
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Simultaneous Quantification of Anandamide and Other Endocannabinoids in Dorsal Vagal Complex of Rat Brainstem by LC-MS
TL;DR: Time dependent accumulation of the endocannabinoids (AEA, DEA, and NADA) in brain tissue was also studied, which included a novel examination of the accumulation of DEA as a function of time in rat brain tissue after decapitation.