Journal ArticleDOI
Understanding the pathway of antibacterial activity of copper oxide nanoparticles
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In this paper, the role of oxidation state in the antibacterial activity of copper oxide nanoparticles (NPs) was investigated and the findings add strong support to a contact killing mechanism of copper oxides (CuO and Cu2O) through which bacteria initially suffer severe damage to the cell envelope.Abstract:
This work investigates the role of oxidation state in the antibacterial activity of copper oxide nanoparticles (NPs). The findings add strong support to a contact killing mechanism of copper oxides (CuO and Cu2O) through which bacteria initially suffer severe damage to the cell envelope. Then further damage ensues by an independent pathway of each copper oxide nanoparticle. Formation of copper(I)–peptide complex from cuprous oxide (Cu2O) and free radical generation from cupric oxide (CuO) were identified as key sources of toxicity towards E.coli. Cu2O rapidly inactivated Fumarase A, an iron sulphur cluster enzyme suggesting the cuprous state of copper binding to the proteins. This inactivation was not noticed in CuO. The percentage of biocidal/bacteriostatic activity is closely related to the oxidation state of the copper oxides. In the case of E.coli, Cu2O nanoparticles showed more efficient antibacterial activity and higher affinity to the bacterial cells. CuO nanoparticles produced significant ROS in terms of super oxides while Cu2O did not. The diminishing defective emission peaks of Cu2O after incubation with microbes strongly suggest the formation of protein complexes. This work is carried out to enable better understanding of the mechanistic pathways of copper oxide nanoparticles.read more
Citations
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Metal nanoparticles: understanding the mechanisms behind antibacterial activity.
TL;DR: Proposed mechanisms of antibacterial action of different metal NPs include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction.
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Synthesis and Biomedical Applications of Copper Oxide Nanoparticles: An Expanding Horizon.
Nishant Verma,Nikhil Kumar +1 more
TL;DR: This review article attempts to summarize the recent advancements in the various synthetic approaches toward copper oxide nanoparticles and their biomedical applications, and highlights various synthetic methodologies including electrochemical, chemical, and biogenic methods, the role of surface modifiers in growth mechanisms, and their impact on biomedical applications.
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Metal Oxide Nanoparticles as Biomedical Materials
Maria P. Nikolova,Murthy Chavali +1 more
TL;DR: In this review, a comprehensive review of researches on metal oxide nanoparticles, their nanoscale physicochemical properties, defining specific applications in the various fields of nanomedicine are provided.
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Metal-Based Nanoparticles for the Treatment of Infectious Diseases
TL;DR: This review will focus on the recent reports of metal-based nanoparticles that are potential therapeutics for the treatment of infectious diseases and their biological efficacy (in vitro and in vivo).
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The potential exposure and hazards of copper nanoparticles: A review.
Thelma Ameh,Christie M. Sayes +1 more
TL;DR: The antimicrobial potential of copper nanoparticles makes them excellent components for application in biomedicine and more recently, they have been investigated for applications as drug delivery agents in cancer therapy.
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Journal ArticleDOI
Characterisation of copper oxide nanoparticles for antimicrobial applications
TL;DR: The ability of CuO nanoparticles to reduce bacterial populations to zero was enhanced in the presence of sub-MBC concentrations of silver nanoparticles, suggesting release of ions may be required for optimum killing.