Upgrading and Downgrading of Prostate Cancer from Biopsy to Radical Prostatectomy: Incidence and Predictive Factors Using the Modified Gleason Grading System and Factoring in Tertiary Grades
TLDR
Despite factoring in multiple variables including the number of positive cores and the maximum percentage of cancer per core, the concordance indexes were not sufficiently high to justify the use of nomograms for predicting upgrading and downgrading for the individual patient.About:
This article is published in European Urology.The article was published on 2012-05-01 and is currently open access. It has received 564 citations till now. The article focuses on the topics: Gleason grading system & Biopsy.read more
Citations
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Journal ArticleDOI
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.
Jonathan I. Epstein,Lars Egevad,Mahul B. Amin,Brett Delahunt,John R. Srigley,Peter A. Humphrey +5 more
TL;DR: The basis for a new grading system was proposed in 2013 by one of the authors and accepted by the World Health Organization for the 2016 edition of Pathology and Genetics: Tumours of the Urinary System and Male Genital Organs.
Journal ArticleDOI
A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score.
Jonathan I. Epstein,Michael J. Zelefsky,Daniel Sjöberg,Joel B. Nelson,Lars Egevad,Cristina Magi-Galluzzi,Andrew J. Vickers,Anil V. Parwani,Victor E. Reuter,Samson W. Fine,James A. Eastham,Peter Wiklund,Misop Han,Chandana A. Reddy,Jay P. Ciezki,Tommy Nyberg,Eric A. Klein +16 more
TL;DR: Looking at outcomes for prostate cancer treated with radical prostatectomy or radiation therapy and validated a new grading system with more accurate grade stratification than current systems, including a simplified grading system of five grades and the lowest grade is 1, as opposed to 6, with the potential to reduce overtreatment of PCa.
Journal ArticleDOI
MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis
Michael Ahdoot,Andrew R Wilbur,Sarah E Reese,Amir H. Lebastchi,Sherif Mehralivand,Patrick T. Gomella,Jonathan Bloom,Sandeep Gurram,Minhaj Siddiqui,Paul F. Pinsky,Howard L. Parnes,W. Marston Linehan,Maria Merino,Peter L. Choyke,Joanna H. Shih,Baris Turkbey,Bradford J. Wood,Peter A. Pinto +17 more
TL;DR: Among patients with MRI-visible lesions, combined biopsy led to more detection of all prostate cancers, however, MRI-targeted biopsy alone underestimated the histologic grade of some tumors.
Journal ArticleDOI
Comparing Three Different Techniques for Magnetic Resonance Imaging-targeted Prostate Biopsies: A Systematic Review of In-bore versus Magnetic Resonance Imaging-transrectal Ultrasound fusion versus Cognitive Registration. Is There a Preferred Technique?
O. Wegelin,Harm H.E. van Melick,Lotty Hooft,J.L.H. Ruud Bosch,Hans B. Reitsma,Jelle O. Barentsz,Diederik M. Somford +6 more
TL;DR: It is shown that magnetic resonance imaging-guided biopsy detects more clinically significant prostate cancer (PCa) and less insignificant PCa compared with systematic biopsy in men at risk for PCa.
Journal ArticleDOI
Prostate MRI, with or without MRI‐targeted biopsy, and systematic biopsy for detecting prostate cancer
Frankâ€Jan H Drost,Daniël F Osses,Daan Nieboer,Ewout W. Steyerberg,Chris H. Bangma,Monique J. Roobol,Ivo G. Schoots +6 more
TL;DR: The diagnostic accuracy of the index tests MRI only, MRI-targeted biopsy, the MRI pathway and systematic biopsy as compared to template-guidedBiopsy as the reference standard in detecting clinically significant prostate cancer as the target condition was determined.
References
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Journal ArticleDOI
The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma
Geert J.L.H. van Leenders,Theodorus van der Kwast,David J. Grignon,Andrew Evans,Glen Kristiansen,Charlotte F. Kweldam,Geert Litjens,Jesse K. McKenney,Jonathan Melamed,N. Mottet,Gladell P. Paner,Hemamali Samaratunga,Ivo G. Schoots,Jeffry P. Simko,Toyonori Tsuzuki,Murali Varma,Anne Y. Warren,Thomas M. Wheeler,Sean R. Williamson,Kenneth A. Iczkowski +19 more
TL;DR: This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France, where topics brought to consensus included approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns.
Journal ArticleDOI
Upgrading and Downgrading of Prostate Needle Biopsy Specimens: Risk Factors and Clinical Implications
Stephen J. Freedland,Christopher J. Kane,Christopher J. Kane,Christopher L. Amling,Christopher L. Amling,William J. Aronson,William J. Aronson,Martha K. Terris,Martha K. Terris,Joseph C. Presti,Joseph C. Presti +10 more
TL;DR: Men whose disease was upgraded were at a greater risk of adverse pathologic features and biochemical progression, and men with "high-risk" cancer were more likely to have their disease category upgraded, and obtaining more biopsy cores reduced the likelihood of upgrading.
Journal ArticleDOI
Biopsy core number represents one of foremost predictors of clinically significant gleason sum upgrading in patients with low-risk prostate cancer.
Umberto Capitanio,Pierre I. Karakiewicz,Luc Valiquette,Paul Perrotte,Claudio Jeldres,Alberto Briganti,Andrea Gallina,Nazareno Suardi,Andrea Cestari,Giorgio Guazzoni,Andrea Salonia,Francesco Montorsi +11 more
TL;DR: The number of biopsy cores taken represents one of the foremost predictors of GSU and should be taken into consideration during clinical decision-making in patients who are candidates for watchful waiting, active surveillance, or brachytherapy.
Journal ArticleDOI
A Contemporary Study Correlating Prostate Needle Biopsy and Radical Prostatectomy Gleason Score
TL;DR: The last decade has seen the near elimination of once prevalent under grading of needle biopsy, as evidenced by variable over grading and under grading, as well as poor correlation with pathological stage.
Journal ArticleDOI
Prostate biopsy clinical and pathological variables that predict significant grading changes in patients with intermediate and high grade prostate cancer.
TL;DR: To identify the clinical and pathological variables that predict pathological changes in the significant proportion of men with prostate cancer who have an intermediate‐ or high‐grade biopsy Gleason score of ≥7 and who are upgraded or downgraded on interpretation of radical prostatectomy pathological specimens, as GS is critical in treatment decisions.
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