Journal ArticleDOI
Upper Urinary Tract Carcinoma in Lynch Syndrome Cases
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TLDR
Upper urinary tract tumors develop at a younger age and are more likely to be in the ureter with an almost equal gender ratio in patients with Lynch syndrome, which has high grade potential similar to that in the general population.About:
This article is published in The Journal of Urology.The article was published on 2011-05-01. It has received 72 citations till now. The article focuses on the topics: Lynch syndrome & Upper urinary tract.read more
Citations
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Journal ArticleDOI
Comprehensive Genomic Characterization of Upper Tract Urothelial Carcinoma.
Tyler J. Moss,Yuan Qi,Liu Xi,Bo Peng,Tae-Beom Kim,Nader E. Ezzedine,Maribel Mosqueda,Charles C. Guo,Bogdan Czerniak,Michael Ittmann,David A. Wheeler,Seth P. Lerner,Surena F. Matin +12 more
TL;DR: Mutations in UTUC occur at differing frequencies from bladder cancer, with four unique molecular and clinical subtypes with distinct behaviors, including a novel SH3KBP1-CNTNAP5 fusion.
Journal ArticleDOI
A proportion of hereditary upper urinary tract urothelial carcinomas are misclassified as sporadic according to a multi-institutional database analysis: proposal of patient-specific risk identification tool.
François Audenet,Pierre Colin,David R. Yates,Adil Ouzzane,Géraldine Pignot,Jean-Alexandre Long,Michel Soulié,Véronique Phé,Henri Bensadoun,Laurent Guy,Alain Ruffion,Antoine Valeri,Luc Cormier,Stéphane Droupy,Alexandre de la Taille,Fabien Saint,Pierre-Olivier Fais,Alain Houlgatte,Olivier Cussenot,Morgan Rouprêt +19 more
TL;DR: Study Type – Diagnostic (exploratory cohort) and follow-up studies to explore the role of EMT in the development of central nervous system disease and its role in Parkinson's disease.
Journal ArticleDOI
Urinary Tract Cancer in Lynch Syndrome; Increased Risk in Carriers of MSH2 Mutations.
Patrick Joost,Christina Therkildsen,Christina Therkildsen,Mev Dominguez-Valentin,Mats Jönsson,Mef Nilbert,Mef Nilbert +6 more
TL;DR: Cancers of the upper urinary tract and the urinary bladder are included in the Lynch syndrome tumor spectrum, which suggest that surveillance should be targeted at individuals with mutations herein.
Journal ArticleDOI
Upper tract urothelial carcinomas: frequency of association with mismatch repair protein loss and lynch syndrome.
Holly Harper,Jesse K. McKenney,Brandie Heald,Andrew J. Stephenson,Steven C. Campbell,Thomas Plesec,Cristina Magi-Galluzzi +6 more
TL;DR: MLH1 and PMS2 testing appear to have little utility in upper tract urothelial carcinoma; however, mismatch repair protein loss of MSH2 and/or MSH6 by immunohistochemistry seems relatively sensitive and specific for identifying patients with potential Lynch syndrome.
Journal ArticleDOI
The genetic basis of Lynch syndrome and its implications for clinical practice and risk management
Stephanie A Cohen,Anna Leininger +1 more
TL;DR: The history of Lynch Syndrome, the current knowledge of genotype–phenotype correlations, the cancers associated with Lynch syndrome, and management of individuals who are gene carriers are reviewed.
References
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Journal ArticleDOI
CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma
Bertrand Coiffier,Eric Lepage,Josette Brière,Raoul Herbrecht,Hervé Tilly,Reda Bouabdallah,Pierre Morel,Eric Van Den Neste,Gilles Salles,Philippe Gaulard,Felix Reyes,Pierre Lederlin,Christian Gisselbrecht +12 more
TL;DR: A randomized trial to compare CHOP chemotherapy plus rituximab with CHOP alone in elderly patients with diffuse large-B-cell lymphoma found the rate of complete response was significantly higher in the group that received CHOP plus r ituximabs than in thegroup that receivedCHOP alone.
Journal ArticleDOI
Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma
Wen-Kai Weng,Ronald Levy +1 more
TL;DR: Data support the hypothesis that ADCC plays an important role in the clinical effect of rituximab at the level of the effector cell.
Journal ArticleDOI
Extracolonic Cancer in Hereditary Nonpolyposis Colorectal Cancer
Patrice Watson,Henry T. Lynch +1 more
TL;DR: This work has shown that in some but not all families with hereditary nonpolyposis colorectal cancer there is a high risk of certain cancers other than colon cancer.
Journal ArticleDOI
Prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients
M. Craig Hall,Sean Womack,Arthur I. Sagalowsky,Thomas J. Carmody,Mark D Erickstad,Claus G. Roehrborn +5 more
TL;DR: Primary tumor stage and surgical procedure performed (radical versus parenchymal sparing) are important predictors of disease recurrence and survival in patients treated for upper tract transitional cell carcinoma with extended follow-up.
Journal ArticleDOI
The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome
Patrice Watson,Hans F. A. Vasen,Jukka-Pekka Mecklin,Inge Bernstein,Markku Aarnio,Heikki Järvinen,Torben Myrhøj,Lone Sunde,Juul T. Wijnen,Henry T. Lynch +9 more
TL;DR: Urologic tract cancer and ovarian cancer occur frequently enough in some LS subgroups to justify trials to evaluate promising prevention interventions, and other cancer types studied occur too infrequently to justify strenuous cancer control interventions.
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Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability
Asad Umar,C. Richard Boland,Jonathan P. Terdiman,Sapna Syngal,Albert de la Chapelle,Josef Rüschoff,Richard Fishel,Noralane M. Lindor,Lawrence J. Burgart,Richard Hamelin,Stanley R. Hamilton,Robert A. Hiatt,Jeremy R. Jass,Annika Lindblom,Henry T. Lynch,Päivi Peltomäki,Scott D. Ramsey,Miguel A. Rodriguez-Bigas,Hans F. A. Vasen,Ernest T. Hawk,J. Carl Barrett,Andrew N. Freedman,Sudhir Srivastava +22 more