Urate as a Marker of Risk and Progression of Neurodegenerative Disease.
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TLDR
A body of evidence supports the hypothesis that urate may represent a shared pathophysiologic mechanism across neurodegenerative diseases and suggests that it may constitute a novel therapeutic target.About:
This article is published in Neurotherapeutics.The article was published on 2017-01-01 and is currently open access. It has received 72 citations till now. The article focuses on the topics: Neurodegeneration.read more
Citations
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Journal ArticleDOI
Physiology of Hyperuricemia and Urate-Lowering Treatments.
Caroline L. Benn,Pinky Dua,Rachel Gurrell,Peter T. Loudon,Andrew Pike,R. Ian Storer,Ciara Vangjeli +6 more
TL;DR: This work discusses current therapies and emerging drug discovery efforts aimed at delivering an optimized clinical treatment strategy for gout, with a focus on studies which suggest association of hyperuricemia with common comorbidities including cardiovascular disease, renal insufficiency, metabolic syndrome and diabetes.
Journal ArticleDOI
Formate metabolism in health and disease.
TL;DR: The relevance of formate metabolism in the context of embryonic development, cancer, obesity, immunometabolism, and neurodegeneration is discussed, along with an outlook of some open questions bringing formates metabolism into the spotlight.
Journal ArticleDOI
Dairy foods and health: an umbrella review of observational studies
Justyna Godos,Maria Tieri,Francesca Ghelfi,Lucilla Titta,Stefano Marventano,Alessandra Lafranconi,Alessandra Lafranconi,Angelo Gambera,Elena Alonzo,Salvatore Sciacca,Silvio Buscemi,Sumantra Ray,Daniele Del Rio,Fabio Galvano,Giuseppe Grosso +14 more
TL;DR: In conclusions, dairy may be part of a healthy diet; however, additional studies exploring confounding factors are needed to ascertain the potential detrimental effects.
Journal ArticleDOI
Oxidative stress in cerebral small vessel disease. Role of reactive species.
TL;DR: Cerebral small vessel disease is a wide term describing the condition affecting perforating arterial branches as well as arterioles, venules, and capillaries, which can be caused by oxidative stress and inflammatory mechanisms as a result of reactions and processes generating extensive reactive oxygen species (ROS) production.
Journal ArticleDOI
Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease
Daniel Stoessel,Claudia Schulte,Marcia Cristina Teixeira Dos Santos,Dieter Scheller,Irene Rebollo-Mesa,Christian Deuschle,Dirk Walther,Nicolas Schauer,Daniela Berg,Daniela Berg,Andre Nogueira da Costa,Walter Maetzler,Walter Maetzler +12 more
TL;DR: Characteristics of the metabolites indicate perturbations in the glycerophospholipid, sphingolipids, and amino acid metabolism in PD, which underscores the high power of metabolomic approaches.
References
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Journal ArticleDOI
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.
TL;DR: It is shown that, at physiological concentrations, urate reduces the oxo-heme oxidant formed by peroxide reaction with hemoglobin, protects erythrocyte ghosts against lipid peroxidation, and protects ERYthrocytes from peroxidative damage leading to lysis.
Journal ArticleDOI
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
Claire Henchcliffe,M. Flint Beal +1 more
TL;DR: Evidence for the roles of mitochondrial dysfunction and increased oxidative stress in the neuronal loss that leads to PD is examined and how this knowledge might further improve patient management and aid in the development of 'mitochondrial therapy' for PD is discussed.
Journal ArticleDOI
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
Veronique Vitart,Igor Rudan,Igor Rudan,Caroline Hayward,Nicola K. Gray,Nicola K. Gray,James A B Floyd,Colin N. A. Palmer,Sara Knott,Ivana Kolcic,Ozren Polasek,Ozren Polasek,Juergen Graessler,James F. Wilson,Anthony M. Marinaki,Philip Riches,Xinhua Shu,Branka Janićijević,Nina Smolej-Narančić,Barbara Gorgoni,Barbara Gorgoni,Joanne E. Morgan,Susan Campbell,Zrinka Biloglav,Lovorka Barac-Lauc,Marijana Peričić,Irena Martinović Klarić,Lina Zgaga,Tatjana Škarić-Jurić,Sarah H. Wild,William A. Richardson,Peter Hohenstein,Charley H Kimber,Albert Tenesa,Louise A. Donnelly,Lynette D. Fairbanks,Martin Aringer,Paul M. McKeigue,Stuart H. Ralston,Andrew D. Morris,Pavao Rudan,Nicholas D. Hastie,Harry Campbell,Alan F. Wright +43 more
TL;DR: Genetic variants within a transporter gene, SLC2A9, that explain 1.7–5.3% of the variance in serum uric acid concentrations are identified following a genome-wide association scan in a Croatian population sample and it is shown that it has strong uric Acid transport activity in Xenopus laevis oocytes.
Journal ArticleDOI
Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease
Wenzhen Duan,Bruce Ladenheim,Roy G. Cutler,Inna I. Kruman,Jean Lud Cadet,Mark P. Mattson,Mark P. Mattson +6 more
TL;DR: The ability of folate deficiency and elevated homocysteine levels to sensitize dopaminergic neurons to environmental toxins suggests a mechanism whereby dietary folate may influence risk for PD.
Journal ArticleDOI
Metabolomic profiling to develop blood biomarkers for Parkinson's disease.
Mikhail B. Bogdanov,Wayne R. Matson,Lei Wang,Theodore D. Matson,Rachel Saunders-Pullman,Susan Bressman,M. Flint Beal +6 more
TL;DR: In this article, the authors used metabolomic profiling using high performance liquid chromatography coupled with electrochemical coulometric array detection (LCECA) to look for biomarkers in plasma useful for the diagnosis of Parkinson's disease.
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