Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population
Hans L. Hillege,Vaclav Fidler,Gilles F. H. Diercks,Wiek H. van Gilst,Dick de Zeeuw,Dirk J. van Veldhuisen,Rijk O. B. Gans,Wilbert M.T. Janssen,Diederick E. Grobbee,Paul E. de Jong +9 more
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Urinary albumin excretion is a predictor of all-cause mortality in the general population and the excess risk was more attributable to death from CV causes, independent of the effects of other CV risk factors.Abstract:
Background— For the general population, the clinical relevance of an increased urinary albumin excretion rate is still debated. Therefore, we examined the relationship between urinary albumin excretion and all-cause mortality and mortality caused by cardiovascular (CV) disease and non-CV disease in the general population. Methods and Results— In the period 1997 to 1998, all inhabitants of the city of Groningen, the Netherlands, aged between 28 and 75 years (n=85 421) were sent a postal questionnaire collecting information about risk factors for CV disease and CV morbidity and a vial to collect an early morning urine sample for measurement of urinary albumin concentration (UAC). The vital status of the cohort was subsequently obtained from the municipal register, and the cause of death was obtained from the Central Bureau of Statistics. Of these 85 421 subjects, 40 856 (47.8%) responded, and 40 548 could be included in the analysis. During a median follow-up period of 961 days (maximum 1139 days), 516 deat...read more
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2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
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