Journal ArticleDOI
Use of selectively trypsinized nucleosome core particles to analyze the role of the histone “tails” in the stabilization of the nucleosome
TLDR
Stability of the nucleosome core particle to dissociation is not affected by the presence or the absence of any of the N-terminal regions of the histones, and these histone regions make very little contribution, if any, to the conformational transition that nucleosomes undergo in this range of salt concentrations.About:
This article is published in Journal of Molecular Biology.The article was published on 1989-04-05. It has received 313 citations till now. The article focuses on the topics: Linker DNA & Histone octamer.read more
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Intrinsically Disordered Proteins
TL;DR: The sequence-structure relationships indicate that disorder is an encoded property, and the predictions strongly suggest that proteins in nature are much richer in intrinsic disorder than are those in the Protein Data Bank.
Journal ArticleDOI
Alteration of Nucleosome Structure as a Mechanism of Transcriptional Regulation
TL;DR: Recently, proteins that were initially identified as necessary for transcriptional regulation have been shown to alter nucleosomal structure and are likely to play a central role in appropriate regulation of eukaryotic genes.
Journal ArticleDOI
A positive role for histone acetylation in transcription factor access to nucleosomal DNA
TL;DR: It is suggested that the hist one tails have a major role in restricting transcription factor access to DNA and that their acetylation releases this restriction by directing dissociation of the tails from DNA and/or inducing a change in DNA configuration on the histone core to allow transcription factor binding.
Journal ArticleDOI
Signaling to Chromatin through Histone Modifications
TL;DR: This review concludes with a recommendation that further studies are needed into the determinants of immune-inflammatory bowel disease and the Kessler-Corsi verdict is in order.
Journal ArticleDOI
Histone methylation versus histone acetylation: new insights into epigenetic regulation.
Judd C. Rice,C. David Allis +1 more
TL;DR: Taken together, these new findings suggest that histone methylation may provide a stable genomic imprint that may serve to regulate gene expression as well as other epigenetic phenomena.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Different conformations of double‐stranded nucleic acid in solution as revealed by circular dichroism
TL;DR: Conformation of two‐stranded DNA in H 2O–methanol, H2O–ethanol), H2 O–isopropanol, and H2o–dioxane solutions at different concentrations of alkaline ions has been studied with the aid of circular dichroism.
Journal ArticleDOI
The histone core complex: an octamer assembled by two sets of protein-protein interactions.
TL;DR: It is demonstrated that the bonds maintaining the octameric complex in 2 M NaCl are weak and distinctly different from the forces stabilizing the H2A-H2B dimer or H3-H4 tetramer, suggesting that these weak interactions might be derived predominantly from histidine-lysine or Histidine-tyrosine hydrogen bonds between the dimer and tetramer subunits.