Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Birgitta Olofsson,Katri Pajusola,Arja Kaipainen,G. von Euler,Vladimir Joukov,Olli Saksela,Arto Orpana,R F Pettersson,Kari Alitalo,Ulf Eriksson +9 more
TLDR
The results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.Abstract:
We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.read more
Citations
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Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
TL;DR: The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute.
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Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
TL;DR: The recent approval of bevacizumab by the US FDA as a first-line therapy for metastatic colorectal cancer validates the ideas that VEGF is a key mediator of tumour angiogenesis and that blockingAngiogenesis is an effective strategy to treat human cancer.
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Vascular Endothelial Growth Factor and Angiogenesis
Ann Hoeben,Bart Landuyt,Martin Highley,Hans Wildiers,Allan T. van Oosterom,Ernst A. de Bruijn +5 more
TL;DR: The role of V EGF in physiological and pathological processes is reviewed and how modulation of VEGF expression creates new therapeutic possibilities is discussed.
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