Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior.
Kelly M. Dumais,Alexa H. Veenema +1 more
TLDR
This review discusses the evidence showing the presence or absence of sex differences in VP and OT receptors in rodents and humans, as well as showing new data of sexually dimorphic V1a receptor binding in the rat brain.About:
This article is published in Frontiers in Neuroendocrinology.The article was published on 2016-01-01 and is currently open access. It has received 374 citations till now. The article focuses on the topics: Receptor expression & Social behavior.read more
Citations
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Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity
Mario G. Oyola,Robert J. Handa +1 more
TL;DR: The HPA and HPG axes are discussed and how gonadal steroids interact with the HPA axis to regulate the stress circuitry during all stages in life is reviewed.
Journal ArticleDOI
Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience
TL;DR: Both conserved and variable features of central oxytocin and vasopressin systems are described in the context of social behavioral diversity, with a particular focus on neural networks that modulate social learning, behavior, and salience of sociosensory stimuli during species‐typical social contexts.
Journal ArticleDOI
Social brain, social dysfunction and social withdrawal
Stefano Porcelli,Nic J.A. van der Wee,Steven J.A. van der Werff,Moji Aghajani,Jeffrey C. Glennon,Sabrina van Heukelum,Floriana Mogavero,Antonio Lobo,Francisco Javier Olivera,Elena Lobo,Mar Posadas,Juergen Dukart,Rouba Kozak,Estibaliz Arce,Arfan Ikram,Jacob A. S. Vorstman,Amy C. Bilderbeck,Ilja M.J. Saris,Martien J H Kas,Alessandro Serretti +19 more
TL;DR: Present knowledge linking neurobiological substrates sustaining social functioning, social dysfunction and social withdrawal in major psychiatric disorders, including schizophrenia, AD, SCZ, and MDD are summarized.
Journal ArticleDOI
Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
TL;DR: It is demonstrated using genetic and pharmacological approaches that Oxtrs in the anterior dentate gyrus and anterior CA2/CA3 of mice are necessary for discrimination of social, but not non-social, stimuli and a role is identified for an aDG-CA2/ CA3 axis of Oxtr expressing cells indiscrimination of social stimuli.
Journal ArticleDOI
Insular cortex mediates approach and avoidance responses to social affective stimuli.
Morgan M. Rogers-Carter,Juan A. Varela,Katherine B. Gribbons,Anne F. Pierce,Morgan T. McGoey,Maureen Ritchey,John P. Christianson +6 more
TL;DR: In a new model, male rats approach stressed juveniles but avoid stressed adults; these behaviors require excitatory action of oxytocin within the insular cortex, which implicateinsular cortex as a key component in the circuit underlying age-dependent social responses to stressed conspecifics.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Oxytocin increases trust in humans
TL;DR: It is shown that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
Journal ArticleDOI
The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
Journal ArticleDOI
Hypothalamic Integration: Organization of the Paraventricular and Supraoptic Nuclei
Journal ArticleDOI
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
TL;DR: OXT and AVP are emerging as targets for novel treatment approaches — particularly in synergistic combination with psychotherapy — for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.
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The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more