Journal ArticleDOI
Vegetable Organosulfur Compounds and their Health Promoting Effects.
TLDR
The mechanisms of action of organosulfur compounds have started to unravel, with promising results for further exploitation of these significant bioactive compounds in drug development and novel nutraceutical products.Abstract:
Background: Trends in modern pharmaceutical science show an increase in demand for new drugs and diet supplements derived from natural products, while during the last decades, great research is conducted regarding the natural compounds and their medicinal and bioactive properties Organosulfur compounds are present in many plants and their bioactive properties have been used in folk and traditional medicine throughout the centuries Not until recently, modern science confirmed and revealed the chemical compounds that are responsible for these properties, the chemistry involved in their biosynthesis and the main mechanisms of action Objective: In the present review, the organosulfur compounds of vegetable origin and their health effects are presented, focusing on the chemical composition of their main compounds, their biosynthesis and the mechanisms involved in their health effects Sulfur compound sources presented include mainly vegetable species belonging to Allium genus and Brassicaceae family Conclusion: Organosulfur compounds of vegetable sources are very important in human diet, and their regular consumption has a beneficial contribution to health and well-being Moreover, their medicinal properties and therapeutic effects have been described thousands of years ago, while they constitute an important ingredient in traditional medicines and preparations However, not until recently, the mechanisms of action of organosulfur compounds have started to unravel, with promising results for further exploitation of these significant bioactive compounds in drug development and novel nutraceutical products This review reveals the numerous biological activities of organosulfur compounds of vegetable origin, while it also presents the results of recent clinical studies and trialsread more
Citations
More filters
Journal ArticleDOI
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
TL;DR: A better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.
Journal ArticleDOI
Fruits and vegetables, as a source of nutritional compounds and phytochemicals: Changes in bioactive compounds during lactic fermentation.
TL;DR: Interactions between ingested fermented food, intestinal microbiota and their correlations to metabolomics profiles and health represent an important perspective deserving to be further explored.
Journal ArticleDOI
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases.
Samanta C. Funes,Mariana Ríos,Ayleen Fernández-Fierro,Camila Covián,Susan M. Bueno,Claudia A. Riedel,Juan Pablo Mackern-Oberti,Juan Pablo Mackern-Oberti,Alexis M. Kalergis +8 more
TL;DR: It is concluded that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health and opens a new outlook on the investigation of naturally derivedHO-1 inducers, mainly concerning autoimmunity.
Ajoene a Stable Garlic By-Product. Has an Antioxidant Effect through Nrf2-Mediated Glutamate-Cysteine Ligase Induction in HepG2
Hee Yeon Kay,Jin Won Yang,Tae Hyun Kim,Da Yeon Lee,Bomi Kang,Jae-Ha Ryu,Raok Jeon,Sang Geon Kim +7 more
TL;DR: Agarwal et al. as mentioned in this paper investigated whether ajoene, a chemically stable garlic byproduct, has the ability to activate Nrf2 and induce glutamate-cysteine ligase (GCL) and, if so, what is the role of activating nrf2 in cytoprotection against oxidative stress.
Journal ArticleDOI
Zinc and Iron Agronomic Biofortification of Brassicaceae Microgreens
Francesco Di Gioia,Spyridon A. Petropoulos,Monica Ozores-Hampton,Kelly T. Morgan,Erin N. Rosskopf +4 more
TL;DR: In this article, the authors evaluated the potential for bio-fortification of Brassicaceae microgreens through Zn and Fe enrichment using a quadratic model and found significant interactions between Zn or Fe level and the species examined.
References
More filters
Journal ArticleDOI
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
TL;DR: The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway, and this review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses.
Journal ArticleDOI
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
Jing Yang,Robert A. Weinberg +1 more
TL;DR: This review summarizes and compares major signaling pathways that regulate the epithelial-mesenchymal transitions during both development and tumor metastasis and examines their role in carcinoma invasion and metastasis.
Journal ArticleDOI
Biology and biochemistry of glucosinolates
TL;DR: Glucosinolates are sulfur-rich, anionic natural products that upon hydrolysis by endogenous thioglucosidases called myrosinases produce several different products that function as cancer-preventing agents, biopesticides, and flavor compounds.
Journal ArticleDOI
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
TL;DR: Sulforaphane is the most potent inducer, and the presence of oxygen on sulfur enhances potency, which may be a significant component of the anticarcinogenic action of broccoli.
Journal ArticleDOI
Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?
TL;DR: It is proposed here that the hyperglycemia- induced, and possibly FFA-induced, activation of stress pathways plays a key role in the development of not only the late complications in type 1 and type 1 diabetes, but also the insulin resistance and impaired insulin secretion seen in type 2 diabetes.
Related Papers (5)
Brassicaceae: a rich source of health improving phytochemicals
Pinarosa Avato,M. P. Argentieri +1 more