Journal ArticleDOI
VEGF receptor protein-tyrosine kinases: structure and regulation.
TLDR
The VEGF family of receptors consists of three protein-tyrosine kinases (VEGFR1, V EGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropil in-2).About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2008-10-24. It has received 229 citations till now. The article focuses on the topics: Tyrosine phosphorylation & Vasculogenesis.read more
Citations
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Journal ArticleDOI
ERK1/2 MAP kinases: structure, function, and regulation.
TL;DR: The activity of the Ras-Raf-MEK-ERK cascade is increased in about one-third of all human cancers, and inhibition of components of this cascade by targeted inhibitors represents an important anti-tumor strategy.
Journal ArticleDOI
Targeting angiogenesis: progress with anti-VEGF treatment with large molecules.
Axel Grothey,Evanthia Galanis +1 more
TL;DR: This Review will discuss the rationale for using antiangiogenic compounds and will focus on large molecules, such as antibodies, that target the VEGF system, and clinical data on bevacizumab is discussed in detail.
Journal ArticleDOI
VHL and HIF signalling in renal cell carcinogenesis
Marcella M. Baldewijns,Iris J. H van Vlodrop,Peter B. Vermeulen,Patricia M. M. B. Soetekouw,Manon van Engeland,Adriaan P. de Bruïne +5 more
TL;DR: In this paper, the authors discuss existing and novel findings about RCC carcinogenesis, with subsequent clinical implications, and suggest new targeting approaches such as inhibition of HIF-driven key metabolic enzymes and introduce new HIF targeting agents, such as histone deacetylase inhibitors, with successful anti-neoplastic effects.
Journal ArticleDOI
Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2.
Chloe J. Peach,Viviane W. Mignone,Viviane W. Mignone,Maria Augusta Arruda,Maria Augusta Arruda,Diana C Alcobia,Diana C Alcobia,Stephen J. Hill,Stephen J. Hill,Laura E. Kilpatrick,Laura E. Kilpatrick,Jeanette Woolard,Jeanette Woolard +12 more
TL;DR: To understand how VEGF-A isoforms have distinct signalling despite similar affinities for VEGFR2, this review re-evaluates the typical classification of these isoforms relative to the prototypical, “pro-angiogenic” V EGF165a.
Journal ArticleDOI
Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis
TL;DR: In this article, the authors discuss several possible mechanisms reported by different labs which mediate formation of the complex between VEGFR-2 and αvβ3 on endothelial cells, and pathological consequences and regulatory events involved in this receptor cross-talk are also presented.
References
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Journal ArticleDOI
Cell signaling by receptor-tyrosine kinases
TL;DR: Understanding of the complex signaling networks downstream from RTKs and how alterations in these networks are translated into cellular responses provides an important context for therapeutically countering the effects of pathogenic RTK mutations in cancer and other diseases.
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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
TL;DR: Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
Fouad Shalaby,Janet Rossant,Janet Rossant,Terry P. Yamaguchi,Terry P. Yamaguchi,Marina Gertsenstein,Xiang-Fu Wu,Xiang-Fu Wu,Martin L. Breitman,Martin L. Breitman,Andre C. Schuh +10 more
TL;DR: The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo.
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VEGF receptor signalling - in control of vascular function.
TL;DR: Recent insights have shed light onto VEGFR signal transduction and the interplay between different V EGFRs and VEGF co-receptors in development, adult physiology and disease.
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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Guo-Hua Fong,Janet Rossant,Janet Rossant,Marina Gertsenstein,Martin L. Breitman,Martin L. Breitman +5 more
TL;DR: It is reported that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation, and it is suggested that the FlT-1 signalling pathway may regulate normal endothelium cell-cell or cell-matrix interactions during vascular development.