Journal ArticleDOI
Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult mice.
TLDR
VARA attenuated neonatal hyperoxia‐induced neurobehavioral impairment and associated reductions in hippocampal volume in adult mice, possibly by increasing mTOR signaling and synaptic density, and may be effective in other models of oxidant stress as well.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2017-05-01. It has received 11 citations till now. The article focuses on the topics: Hyperoxia & Lung injury.read more
Citations
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Journal ArticleDOI
Postnatal Nutrition to Improve Brain Development in the Preterm Infant: A Systematic Review From Bench to Bedside.
Lisa M. Hortensius,Ruurd M. van Elburg,Cora H. Nijboer,Manon J.N.L. Benders,Caroline Gillis Marleen De Theije +4 more
TL;DR: Even though many pre-clinical trials demonstrate promising effects of different nutritional interventions on reducing brain injury and/or improving neurodevelopmental outcome, these positive effects have so far not evidently been demonstrated in RCTs.
Journal ArticleDOI
Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation
Anushruti Ashok,Syed Suhail Andrabi,Saffar Mansoor,Youzhi Kuang,Brian K. Kwon,Vinod Labhasetwar +5 more
TL;DR: A comprehensive analysis of the potential of antioxidant therapy, challenges in their clinical translation, and the role nanoparticles/drug delivery systems could play in addressing these challenges is provided.
Journal ArticleDOI
Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects.
Raffaele Falsaperla,Filadelfo Lombardo,Federica Filosco,Catia Romano,Marco Andrea Nicola Saporito,Federica Puglisi,Ettore Piro,Martino Ruggieri,Piero Pavone +8 more
TL;DR: The most recent studies show that a strong relationship between oxidative stress and prematurity exists and that, unfortunately, there is still little therapeutic evidence reported in the literature.
Journal ArticleDOI
Using Experimental Models to Identify Pathogenic Pathways and Putative Disease Management Targets in Bronchopulmonary Dysplasia.
Rory E. Morty,Rory E. Morty +1 more
TL;DR: There is a pressing need to refine existing models to better recapitulate pathological processes at play in affected infants, in order to better evaluate new candidate pharmacological and other interventions for the management of BPD.
Journal ArticleDOI
Early Life Supraphysiological Levels of Oxygen Exposure Permanently Impairs Hippocampal Mitochondrial Function.
Manimaran Ramani,Kiara Miller,Jamelle A. Brown,Ranjit Kumar,Jegen Kadasamy,Lori L. McMahon,Scott W. Ballinger,Namasivayam Ambalavanan +7 more
TL;DR: In this article, the authors found that hyperoxia exposure reduced mitochondrial ATP-linked oxygen consumption and increased state 4 respiration linked proton leak in both neonatal and young adult mice while complex I function was decreased at P2-P14 but increased in young adults.
References
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Book
The Mouse Brain in Stereotaxic Coordinates
TL;DR: The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use and includes a CD of all plates and diagrams, as well as Adobe Illustrator files of the diagrams, and a variety of additional useful material.
Journal ArticleDOI
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
TL;DR: The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.
Journal ArticleDOI
The Open-Field Test: a critical review.
Roger Walsh,Robert A. Cummins +1 more
TL;DR: Over the w t 4 0 years Lhc open field bar ~ o l v e d a a commonly used tool for the rnmumcnt of animal behavior ~ a dtical look at the the authors of instrument, with regard to the development of a standard form for iu w.
Journal ArticleDOI
Applications of the Morris water maze in the study of learning and memory.
Rudi D'Hooge,Peter Paul De Deyn +1 more
TL;DR: Lesions in distinct brain regions like hippocampus, striatum, basal forebrain, cerebellum and cerebral cortex were shown to impair MWM performance, but disconnecting rather than destroying brain regions relevant for spatial learning may impair M WM performance as well.
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Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children.
Cornelieke S.H. Aarnoudse-Moens,Nynke Weisglas-Kuperus,Johannes B. van Goudoever,Jaap Oosterlaan +3 more
TL;DR: Very preterm and/or VLBW children have moderate-to-severe deficits in academic achievement, attention problems, and internalizing behavioral problems and poor EF, which are adverse outcomes that were strongly correlated to their immaturity at birth.