Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs
TLDR
This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors can alter immediate and long-term barrier function and disease susceptibility.About:
This article is published in Animal Nutrition.The article was published on 2017-12-01 and is currently open access. It has received 236 citations till now. The article focuses on the topics: Barrier function.read more
Citations
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Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria
Xiaofan Wang,Tsungcheng Tsai,Feilong Deng,Feilong Deng,Xiaoyuan Wei,Jianmin Chai,Joshua Knapp,Jason K. Apple,Charles V Maxwell,Jung Ae Lee,Ying Li,Jiangchao Zhao +11 more
TL;DR: The distinct stage-associated swine gut microbiome may be determined by the differences in diet and/or gut physiology at different growth stages, and the importance of optimizing stage-specific probiotics aimed at improving animal health and production is underscored.
Journal ArticleDOI
Gastrointestinal tract (gut) health in the young pig
TL;DR: ‘gut health’ represents the outcome of the GIT in response to its capacity and ability to respond and adapt to the insults and challenges it encounters and is of obvious interest in the newly-weaned pig.
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Nutritional Intervention for the Intestinal Development and Health of Weaned Pigs.
TL;DR: This review summarizes the current understanding of nutritional intervention on intestinal health and development of weaned pigs and the importance of mechanistic studies focusing on this research area.
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Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs.
Donghyun Shin,Sung Yong Chang,Paul Bogere,Kyeong-Hye Won,Jae-Young Choi,Yeon-jae Choi,Hak Kyo Lee,Jin Hur,Byung-Yong Park,Younghoon Kim,Jaeyoung Heo +10 more
TL;DR: The data suggest that L. plantarum JDFM LP11 increases the diversity and richness in the microbial community, and attenuates the ileal immune gene expression towards gut inflammation, promoting intestinal development in weaned piglets.
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Diet and the Microbiota-Gut-Brain Axis: Sowing the Seeds of Good Mental Health.
Kirsten Berding,Klára Vlčková,Wolfgang Marx,Harriët Schellekens,Catherine Stanton,Gerard Clarke,Felice N. Jacka,Timothy G. Dinan,John F. Cryan +8 more
TL;DR: In this paper, the authors summarized the current state of the literature triangulating diet, microbiota, and host behavior/brain processes and discussed potential underlying mechanisms for the responsiveness to a dietary intervention and evidence for the microbiota as an underlying modulator of diet on brain health.
References
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Host-Bacterial Mutualism in the Human Intestine
TL;DR: New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements the authors' biology in ways that are mutually beneficial.
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Intestinal mucosal barrier function in health and disease.
TL;DR: Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli, along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.
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IgE and mast cells in allergic disease
Stephen J. Galli,Mindy Tsai +1 more
TL;DR: Findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders are discussed.
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Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.
Giovanni Barbara,Vincenzo Stanghellini,Roberto De Giorgio,Cesare Cremon,Graeme S. Cottrell,Donatella Santini,Gianandrea Pasquinelli,Antonio Maria Morselli-Labate,Eileen F. Grady,Nigel W. Bunnett,Stephen M. Collins,Roberto Corinaldesi +11 more
TL;DR: Only mast cells in close proximity to nerves were significantly correlated with severity and frequency of abdominal pain/discomfort, and mediator release in proximity to mucosal innervation may contribute to abdominal pain perception in IBS patients.
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Intestinal barrier function: molecular regulation and disease pathogenesis.
TL;DR: Clinical and experimental evidence demonstrating intestinal epithelial barrier dysfunction as a major factor contributing to the predisposition to inflammatory diseases, including food allergy, inflammatory bowel diseases, and celiac disease is summarized.