Wound edge biopsy sites in chronic wounds heal rapidly and do not result in delayed overall healing of the wounds.
TLDR
It is concluded that chronic wounds do not worsen after being biopsied and that wound biopsies are a safe procedure that does not delay overall healing of the chronic wound.Abstract:
Wound biopsies are an essential diagnostic component in the management of chronic wounds. First, the possibility of malignancy or infection in the wound often requires sampling of the wound edge and its bed. Secondly, several practice guidelines recommend biopsying wounds that have not responded to treatment after 2–6 weeks. However, there has always been a concern that the biopsy may worsen the wound and delay overall healing. In this report, we investigated the safety and effects of wound biopsies on overall chronic wound healing rates (advance of the wound edge per week toward the center) before and after the biopsy was performed. In a cohort of 14 consecutive patients with chronic wounds of the lower extremity, we found that postbiopsy chronic wound healing rates (0.99±1.18 mm/week; mean±SD) were not decreased and were actually higher than prebiopsy chronic wound healing rates (0.49±0.85 mm/week; mean±SD, p<0.05). In addition, we documented that healing of the biopsy sites up to the original wound edge occurred within 6 weeks in 11 of the 14 subjects. Therefore, we conclude that chronic wounds do not worsen after being biopsied and that wound biopsies are a safe procedure that does not delay overall healing of the chronic wound.read more
Citations
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Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery ® and the American Venous Forum.
Thomas F. O'Donnell,Marc A. Passman,William A. Marston,William J. Ennis,Michael C. Dalsing,Robert L. Kistner,Fedor Lurie,Peter K. Henke,Monika L. Gloviczki,Bo Eklof,Julianne Stoughton,Sesadri Raju,Cynthia K. Shortell,Joseph D. Raffetto,Hugo Partsch,Lori C. Pounds,Mary E. Cummings,David L. Gillespie,Robert B. McLafferty,Mohammad Hassan Murad,Thomas W. Wakefield,Peter Gloviczki +21 more
TL;DR: Thomas F. O'Donnell, MD, Marc A. Passman and Peter K. Gloviczki as mentioned in this paper, MD, PhD, Bo G. Eklof et al.
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Malignancy and Chronic Leg Ulcers: The Value of Systematic Wound Biopsies: A Prospective, Multicenter, Cross-sectional Study
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References
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Molecular pathogenesis of chronic wounds: The role of β-catenin and c-myc in the inhibition of epithelialization and wound healing
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TL;DR: It is concluded that activation of the beta-catenin/c-myc pathway(s) contributes to impaired healing by inhibiting keratinocyte migration and altering their differentiation.
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TL;DR: It is concluded that chronic ulcers contain distinct subpopulations of cells with different capacity to heal and that gene expression profiling can be utilized to identify them, thereby making surgical debridement more accurate and more efficacious.
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Guidelines for the treatment of diabetic ulcers
David L. Steed,Christopher E. Attinger,Theodore Colaizzi,Mary C. Crossland,Michael G. Franz,Lawrence B. Harkless,Andrew Alan Johnson,Hans Moosa,Martin C. Robson,Thomas Serena,Peter Sheehan,Aristidis Veves,Laurel Wiersma-Bryant +12 more
TL;DR: This panel highlights the need to improve the quality and quantity of wound care in the United States by providing real-time information about pre- and post-surgical complications and treatment options.
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Keratinocyte Migration, Proliferation, and Differentiation in Chronic Ulcers From Patients With Diabetes and Normal Wounds
TL;DR: Using immunohistochemistry to evaluate proliferation, differentiation, adhesion, and migration in keratinocytes along the margin of chronic ulcers from patients with diabetes mellitus may lead to molecular targets for therapies for impaired wound healing.
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TL;DR: 1. Co-chaired this panel, which highlighted the need to understand more fully the role of social media in the medical practice and the role that social media plays in the decision-making process.