X-Ray Luminescence and X-Ray Fluorescence Computed Tomography: New Molecular Imaging Modalities
TLDR
This paper reviews the development of X-ray luminescence andX-ray fluorescence CT and their relative merits and includes current problems and future research directions and the role of these modalities in future molecular imaging applications.Abstract:
X-ray luminescence and X-ray fluorescence computed tomography (CT) are two emerging technologies in X-ray imaging that provide functional and molecular imaging capability. Both emission-type tomographic imaging modalities use external X-rays to stimulate secondary emissions, either light or secondary X-rays, which are then acquired for tomographic reconstruction. These modalities surpass the limits of sensitivity in current X-ray imaging and have the potential of enabling X-ray imaging to extract molecular imaging information. These new modalities also promise to break through the spatial resolution limits of other in vivo molecular imaging modalities. This paper reviews the development of X-ray luminescence and X-ray fluorescence CT and their relative merits. The discussion includes current problems and future research directions and the role of these modalities in future molecular imaging applications.read more
Citations
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Journal ArticleDOI
Generalized Adaptive Gaussian Markov Random Field for X-Ray Luminescence Computed Tomography
TL;DR: Compared to conventional L2 and L1 regularizations, GAGMRF provides a new and efficient model for high quality imaging based on the Bayesian framework.
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Proton-induced x-ray fluorescence CT imaging
Magdalena Bazalova-Carter,Moiz Ahmad,Taeko Matsuura,Seishin Takao,Yuto Matsuo,Rebecca Fahrig,Hiroki Shirato,Kikuo Umegaki,Lei Xing +8 more
TL;DR: Proton-induced x-ray fluorescence CT imaging of 3%-5% gold solutions in a small animal sized water phantom has been demonstrated for the first time by means of experiments and Monte Carlo simulations.
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Longitudinal In-Vivo X-Ray Fluorescence Computed Tomography With Molybdenum Nanoparticles
Kian Shaker,Carmen Vogt,Yurika Katsu-Jiménez,Raoul Kuiper,Kenth Andersson,Yuyang Li,Jakob C. Larsson,Aida Rodriguez-Garcia,Muhammet S. Toprak,Marie Arsenian-Henriksson,Hans M. Hertz +10 more
TL;DR: It is concluded that the presented imaging arrangement has potential for in vivo longitudinal studies, putting emphasis on designing biocompatible NPs as the future focus for active-targeting preclinical XFCT.
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Dual-energy fluorescent x-ray computed tomography system with a pinhole design: Use of K-edge discontinuity for scatter correction.
Tenta Sasaya,Naoki Sunaguchi,Thet Thet-Lwin,Kazuyuki Hyodo,Tsutomu Zeniya,Tohoru Takeda,Tetsuya Yuasa +6 more
TL;DR: A pinhole-based fluorescent x-ray computed tomography system with a 2-D detector and volumetric beam that can suppress the quality deterioration caused by scatter components is proposed and improved the contrast-to-noise ratio by more than 2.5.
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Single-view cone-beam x-ray luminescence optical tomography based on Group_YALL1 method.
TL;DR: A sparsity reconstruction method based on group information, termed Group_YALL1, which can accurately resolve the NPs embedded in the object, even if they are close to each other, and has the potential to greatly reduce the data acquisition time while preserving a high imaging quality.
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