Showing papers on "European union published in 2012"
TL;DR: The study of antibiotic resistance has been historically concentrated on the analysis of bacterial pathogens and on the consequences of acquiring resistance for human health, but the studies on antibiotic resistance should not be confined to clinical-associated ecosystems.
Abstract: Work in our laboratory is supported by grants BIO2008-00090 from the Spanish Ministry of Science and Innovation and KBBE-227258 (BIOHYPO), HEALTH-F3-2011-282004 (EVOTAR), and HEALTH-F3-2010-241476 (PAR) from European Union.
2,103 citations
TL;DR: De novo mutations represent an important cause of intellectual disability; exome sequencing was used as an effective diagnostic strategy for their detection.
Abstract: Background The causes of intellectual disability remain largely unknown because of extensive clinical and genetic heterogeneity. Methods We evaluated patients with intellectual disability to exclude known causes of the disorder. We then sequenced the coding regions of more than 21,000 genes obtained from 100 patients with an IQ below 50 and their unaffected parents. A data-analysis procedure was developed to identify and classify de novo, autosomal recessive, and X-linked mutations. In addition, we used high-throughput resequencing to confirm new candidate genes in 765 persons with intellectual disability (a confirmation series). All mutations were evaluated by molecular geneticists and clinicians in the context of the patients' clinical presentation. Results We identified 79 de novo mutations in 53 of 100 patients. A total of 10 de novo mutations and 3 X-linked (maternally inherited) mutations that had been previously predicted to compromise the function of known intellectual-disability genes were found in 13 patients. Potentially causative de novo mutations in novel candidate genes were detected in 22 patients. Additional de novo mutations in 3 of these candidate genes were identified in patients with similar phenotypes in the confirmation series, providing support for mutations in these genes as the cause of intellectual disability. We detected no causative autosomal recessive inherited mutations in the discovery series. Thus, the total diagnostic yield was 16%, mostly involving de novo mutations. Conclusions De novo mutations represent an important cause of intellectual disability; exome sequencing was used as an effective diagnostic strategy for their detection. (Funded by the European Union and others.).
1,239 citations
TL;DR: Some of the VANET research challenges that still need to be addressed to enable the ubiquitous deployment and widespead adoption of scalable, reliable, robust, and secure VANet architectures, protocols, technologies, and services are outlined.
Abstract: Recent advances in hardware, software, and communication technologies are enabling the design and implementation of a whole range of different types of networks that are being deployed in various environments. One such network that has received a lot of interest in the last couple of years is the Vehicular Ad-Hoc Network (VANET). VANET has become an active area of research, standardization, and development because it has tremendous potential to improve vehicle and road safety, traffic efficiency, and convenience as well as comfort to both drivers and passengers. Recent research efforts have placed a strong emphasis on novel VANET design architectures and implementations. A lot of VANET research work have focused on specific areas including routing, broadcasting, Quality of Service (QoS), and security. We survey some of the recent research results in these areas. We present a review of wireless access standards for VANETs, and describe some of the recent VANET trials and deployments in the US, Japan, and the European Union. In addition, we also briefly present some of the simulators currently available to VANET researchers for VANET simulations and we assess their benefits and limitations. Finally, we outline some of the VANET research challenges that still need to be addressed to enable the ubiquitous deployment and widespead adoption of scalable, reliable, robust, and secure VANET architectures, protocols, technologies, and services.
1,132 citations
TL;DR: In this article, the debates regarding place-neutral versus place-based policies for economic development are examined in the context of how development policy thinking on the part of both scholars and international organizations has evolved over several decades, and the cases of the developing world and the European Union are used as examples of how in this changing context development intervention should increasingly focus on efficiency and social inclusion at the expense of an emphasis on territorial convergence.
Abstract: The paper examines the debates regarding place-neutral versus place-based policies for economic development. The analysis is set in the context of how development policy thinking on the part of both scholars and international organizations has evolved over several decades. Many of the previously accepted arguments have been called into question by the impacts of globalization and a new response to these issues has emerged, a response both to these global changes and also to nonspatial development approaches. The debates are highlighted in the context of a series of major reports recently published on the topic. The cases of the developing world and the European Union are used as examples of how in this changing context development intervention should increasingly focus on efficiency and social inclusion at the expense of an emphasis on territorial convergence and how strategies should consider economic, social, political, and institutional diversity in order to maximize both the local and the aggregate potential for economic development.
992 citations
TL;DR: The Operational Sea Surface Temperature (SST) and Sea Ice Analysis (OSTIA) as discussed by the authors system uses satellite SST data provided by international agencies via the Group for High Resolution SST (GHRSST) Regional/Global Task Sharing (R/GTS) framework.
977 citations
TL;DR: This research shows that bilingualism has a somewhat muted effect in adulthood but a larger role in older age, protecting against cognitive decline, a concept known as 'cognitive reserve'.
972 citations
TL;DR: It is shown that a significant number of species are threatened as a result of international trade along complex routes, and that, in particular, consumers in developed countries cause threats to species through their demand of commodities that are ultimately produced in developing countries.
Abstract: Biodiversity threats from Red Lists are linked with patterns of international trade, identifying the ultimate instigators of the threats; developed countries tend to be net importers of implicated commodities, driving biodiversity decline in developing countries. This study develops a global model linking threatened-species records published in the International Union for the Conservation of Nature Red List to worldwide industries causing these threats through the production of commodities such as agricultural crops and timber. Close to one-third of global species threats are due to international trade, according to this model. The resulting 'biodiversity footprint' reveals how consumers in developed countries drive species threats in developing countries. The United States, European Union and Japan emerge as the main final destinations of biodiversity-implicated commodities, with the coffee, rubber, cocoa, palm oil, fisheries and forestry industries among the most destructive. Human activities are causing Earth’s sixth major extinction event1—an accelerating decline of the world’s stocks of biological diversity at rates 100 to 1,000 times pre-human levels2. Historically, low-impact intrusion into species habitats arose from local demands for food, fuel and living space3. However, in today’s increasingly globalized economy, international trade chains accelerate habitat degradation far removed from the place of consumption. Although adverse effects of economic prosperity and economic inequality have been confirmed4,5, the importance of international trade as a driver of threats to species is poorly understood. Here we show that a significant number of species are threatened as a result of international trade along complex routes, and that, in particular, consumers in developed countries cause threats to species through their demand of commodities that are ultimately produced in developing countries. We linked 25,000 Animalia species threat records from the International Union for Conservation of Nature Red List to more than 15,000 commodities produced in 187 countries and evaluated more than 5 billion supply chains in terms of their biodiversity impacts. Excluding invasive species, we found that 30% of global species threats are due to international trade. In many developed countries, the consumption of imported coffee, tea, sugar, textiles, fish and other manufactured items causes a biodiversity footprint that is larger abroad than at home. Our results emphasize the importance of examining biodiversity loss as a global systemic phenomenon, instead of looking at the degrading or polluting producers in isolation. We anticipate that our findings will facilitate better regulation, sustainable supply-chain certification and consumer product labelling.
924 citations
TL;DR: As life expectancy has increased, the number of healthy years lost to disability has also increased in most countries, consistent with the expansion of morbidity hypothesis, which has implications for health planning and health-care expenditure.
908 citations
TL;DR: The main objective of the current study was to outline the current situation and discuss future perspectives for sludge treatment and disposal in EU countries, where sludge reuse in land and sludge incineration seem to be the main practices further adopted in EU-27 (all Member States up to 2020.
853 citations
TL;DR: In this article, the authors present a methodological framework for mapping and assessing ecosystems and their services at European scale, using the water purification service as a case and using functional traits to map ecosystem services.
Abstract: Mainstreaming ecosystem services into policy and decision making is dependent on the availability of spatially explicit information on the state and trends of ecosystems and their services. In particular, the EU Biodiversity Strategy to 2020 addresses the need to account for ecosystem services through biophysical mapping and valuation. This paper reviews current mapping methods, identifies current knowledge gaps and provides the elements for a methodological framework for mapping and assessing ecosystems and their services at European scale. Current mapping methodologies go beyond purely land cover based assessments and include the use of primary data of ecosystem services, the use of functional traits to map ecosystem services and the development of models and ecological production functions. Additional research is needed to cover marine ecosystems and to include the resilience of ecosystems to environmental change in spatially explicit assessments. The ecosystem services cascade which connects ecosystems to human wellbeing is argued to provide a suitable, stepwise framework for mapping ecosystem services in order to support EU policies in a more effective way. We demonstrate the use of this framework for mapping using the water purification service as case.
785 citations
TL;DR: The worldwide story of SFP outbreaks, the characteristics and behaviour of S. aureus in food environment, the toxinogenic conditions and characteristics of SEs, and currently available methods used to characterize staphylococcal outbreaks are focused on.
Abstract: Staphylococcal food poisoning (SFP) is one of the most common food-borne diseases and results from the ingestion of staphylococcal enterotoxins (SEs) preformed in food by enterotoxigenic strains of Staphylococcus aureus. To date, more than 20 SEs have been described: SEA to SElV. All of them have superantigenic activity whereas half of them have been proved to be emetic, representing a potential hazard for consumers. This review, divided into four parts, will focus on the following: (1) the worldwide story of SFP outbreaks, (2) the characteristics and behaviour of S. aureus in food environment, (3) the toxinogenic conditions and characteristics of SEs, and (4) SFP outbreaks including symptomatology, occurrence in the European Union and currently available methods used to characterize staphylococcal outbreaks.
TL;DR: This study identifies and validates new criteria for response to first-line treatment in AL amyloidosis, based on their association with survival in large patient populations, and offers surrogate end points for clinical trials.
Abstract: PURPOSE: To identify the criteria for hematologic and cardiac response to treatment in immunoglobulin light chain (AL) amyloidosis based on survival analysis of a large patient population. PATIENTS AND METHODS: We gathered for analysis 816 patients with AL amyloidosis from seven referral centers in the European Union and the United States. A different cohort of 374 patients prospectively evaluated at the Pavia Amyloidosis Research and Treatment Center was used for validation. Data was available for all patients before and 3 and/or 6 months after initiation of first-line therapy. The prognostic relevance of different criteria for hematologic and cardiac response was assessed. RESULTS: There was a strong correlation between the extent of reduction of amyloidogenic free light chains (FLCs) and improvement in survival. This allowed the identification of four levels of response: amyloid complete response (normal FLC ratio and negative serum and urine immunofixation), very good partial response (difference between involved and uninvolved FLCs [dFLC] 50%), and no response. Cardiac involvement is the major determinant of survival, and changes in cardiac function after therapy can be reliably assessed using the cardiac biomarker N-terminal natriuretic peptide type B (NT-proBNP). Changes in FLC and NT-proBNP predicted survival as early as 3 months after treatment initiation. CONCLUSION: This study identifies and validates new criteria for response to first-line treatment in AL amyloidosis, based on their association with survival in large patient populations, and offers surrogate end points for clinical trials.
TL;DR: The regulatory structure governing the environmental endpoints of BPA in the United States, European Union, and Canada is critically examined, and major challenges to the effective regulation are discussed.
TL;DR: In this article, the authors provide a definition of the Footprint Family as a suite of indicators to track human pressure on the planet and under different angles, based on the premise that no single indicator per se is able to comprehensively monitor human impact on the environment, but indicators rather need to be used and interpreted jointly.
TL;DR: The underlying biology of BRAF, the technology used to identify vemurafenib and its clinical development milestones, along with future prospects based on lessons learned during its development are described.
Abstract: The identification of driver oncogenes has provided important targets for drugs that can change the landscape of cancer therapies. One such example is the BRAF oncogene, which is found in about half of all melanomas as well as several other cancers. As a druggable kinase, oncogenic BRAF has become a crucial target of small-molecule drug discovery efforts. Following a rapid clinical development path, vemurafenib (Zelboraf; Plexxikon/Roche) was approved for the treatment of BRAF-mutated metastatic melanoma in the United States in August 2011 and the European Union in February 2012. This Review describes the underlying biology of BRAF, the technology used to identify vemurafenib and its clinical development milestones, along with future prospects based on lessons learned during its development.
Karolinska Institutet1, Heidelberg University2, Columbia University3, University of Molise4, Tel Aviv University5, University of Oviedo6, Iuliu Hațieganu University of Medicine and Pharmacy7, French Institute of Health and Medical Research8, Nancy-Université9, University of Primorska10, Tallinn University11
TL;DR: Across a range of countries in Europe, using the Young Diagnostic Questionnaire for Internet Addiction yields a prevalence of 'pathological internet use' of 4.4% among adolescents, but varies by country and gender; adolescents lacking emotional and psychological support are at highest risk.
Abstract: Aims To investigate the prevalence of pathological internet use (PIU) and maladaptive internet use (MIU) among adolescents in 11 European countries in relation to demographic, social factors and internet accessibility. Design Cross-sectional survey. Setting The 7th Framework European Union (EU) funded project, Saving and Empowering Young Lives in Europe (SEYLE), is a randomized controlled trial (RCT) evaluating interventions for risk behavioursamongadolescentsinAustria,Estonia,France,Germany,Hungary,Ireland,Israel,Italy,Romania,Slovenia andSpain,withSwedenservingasthecoordinatingcentre.Participants Atotalof 11 956adolescents(female/male: 6731/5225; mean age: 14.9 0.89) recruited from randomly selected schools within the 11 study sites. Measurements Internet users were classified by gender into three categories: adaptive, maladaptive and pathologi- cal, based on their score in the Young Diagnostic Questionnaire for Internet Addiction (YDQ). Findings The overall prevalence of PIU was 4.4%; it was higher among males than females (5.2% versus 3.8%) and differed between countries (c 2 = 309.98; d.f. = 20; P < 0.001). PIU correlated significantly with mean hours online and male gender. Thehighest-rankedonlineactivitieswerewatchingvideos,frequentingchatroomsandsocialnetworking;significantly higherratesof playingsingle-usergameswerefoundinmalesandsocialnetworkinginfemales.Livinginmetropolitan areas was associated with PIU. Students not living with a biological parent, low parental involvement and parental unemployment showed the highest relative risks of both MIU and PIU. Conclusions Across a range of countries in Europe, using the Young Diagnostic Questionnaire for Internet Addiction yields a prevalence of 'pathological internet use' of 4.4% among adolescents, but varies by country and gender; adolescents lacking emotional and psychological support are at highest risk.
02 Jul 2012
TL;DR: Deliberative systems as mentioned in this paper is an approach to ensure that a division of deliberative labour in a system nonetheless meets both deliberative and democratic norms, and examine the problems of implementation in a real world of competing norms, competing institutions and competing powerful interests.
Abstract: 'Deliberative democracy' is often dismissed as a set of small-scale, academic experiments. This volume seeks to demonstrate how the deliberative ideal can work as a theory of democracy on a larger scale. It provides a new way of thinking about democratic engagement across the spectrum of political action, from towns and villages to nation states, and from local networks to transnational, even global systems. Written by a team of the world's leading deliberative theorists, Deliberative Systems explains the principles of this new approach, which seeks ways of ensuring that a division of deliberative labour in a system nonetheless meets both deliberative and democratic norms. Rather than simply elaborating the theory, the contributors examine the problems of implementation in a real world of competing norms, competing institutions and competing powerful interests. This pioneering book will inspire an exciting new phase of deliberative research, both theoretical and empirical.
TL;DR: Therapeutic decisions in stage IV patients should be primarily made by an interdisciplinary oncology team ('Tumour Board'), based on systematic literature reviews and experts' experience.
TL;DR: The European Soil Data Center (ESDAC) as discussed by the authors is one of the data centers established by the European Commission and the European Environment Agency (EEA) to collect soil data and information.
University of Málaga1, University of Genoa2, University of Catania3, University of Turin4, Ege University5, Çanakkale Onsekiz Mart University6, Spanish National Research Council7, Adnan Menderes University8, Stazione Zoologica Anton Dohrn9, Aristotle University of Thessaloniki10, University of Bari11, Aix-Marseille University12, University of Alicante13, Autonomous University of Madrid14, Ca' Foscari University of Venice15
TL;DR: There is an increasing trend in new introductions via the Suez Canal and via shipping, while Lessepsian species decline westwards, while the reverse pattern is evident for ship-mediated species and for those introduced with aquaculture.
Abstract: More than 60 marine non-indigenous species (NIS) have been removed from previous lists and 84 species have been added, bringing the total to 986 alien species in the Mediterranean [775 in the eastern Mediterranean (EMED), 249 in the central Mediterranean (CMED), 190 in the Adriatic Sea (ADRIA) and 308 in the western Mediterranean (WMED)]. There were 48 new entries since 2011 which can be interpreted as approximately one new entry every two weeks. The number of alien species continues to increase, by 2-3 species per year for macrophytes, molluscs and polychaetes, 3-4 species per year for crustaceans, and 6 species per year for fish. The dominant group among alien species is molluscs (with 215 species), followed by crustaceans (159) and polychaetes (132). Macrophytes are the leading group of NIS in the ADRIA and the WMED, reaching 26-30% of all aliens, whereas in the EMED they barely constitute 10% of the introductions. In the EMED, molluscs are the most species-rich group, followed by crustaceans, fish and polychaetes. More than half (54%) of the marine alien species in the Mediterranean were probably introduced by corridors (mainly Suez). Shipping is blamed directly for the introduction of only 12 species, whereas it is assumed to be the most likely pathway of introduction (via ballasts or fouling) of another 300 species. For approximately 100 species shipping is a probable pathway along with the Suez Canal and/or aquaculture. Approximately 20 species have been introduced with certainty via aquaculture, while >50 species (mostly macroalgae), occurring in the vicinity of oyster farms, are assumed to be introduced accidentally as contaminants of imported species. A total of 18 species are assumed to have been introduced by the aquarium trade. Lessepsian species decline westwards, while the reverse pattern is evident for ship-mediated species and for those introduced with aquaculture. There is an increasing trend in new introductions via the Suez Canal and via shipping.
TL;DR: Ten years after the publication of the ARIA World Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children.
Abstract: Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified AR as mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. In its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIA World Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children.
01 Jan 2012
TL;DR: Addressing long waiting times remains a key policy objective along with improving access to providers and increasing attention to public comparison of quality and efficiency indicators, the value of investments in health care and responsiveness to patients needs.
Abstract: Life expectancy in Sweden is high and the country performs well in comparisons related to disease-oriented indicators of health service outcomes and quality of care. The Swedish health system is committed to ensuring the health of all citizens and abides by the principles of human dignity, need and solidarity, and cost-effectiveness. The state is responsible for overall health policy, while the funding and provision of services lies largely with the county councils and regions. The municipalities are responsible for the care of older and disabled people. The majority of primary care centres and almost all hospitals are owned by the county councils. Health care expenditure is mainly tax funded (80%) and is equivalent to 9.9% of gross domestic product (GDP) (2009). Only about 4% of the population has voluntary health insurance (VHI). User charges fund about 17% of health expenditure and are levied on visits to professionals, hospitalization and medicines. The number of acute care hospital beds is below the European Union (EU) average and Sweden allocates more human resources to the health sector than most OECD countries. In the past, the Achilles heel of Swedish health care included long waiting times for diagnosis and treatment and, more recently, divergence in quality of care between regions and socioeconomic groups. Addressing long waiting times remains a key policy objective along with improving access to providers. Recent principal health reforms over the past decade relate to: concentrating hospital services; regionalizing health care services, including mergers; improving coordinated care; increasing choice, competition and privatization in primary care; privatization and competition in the pharmacy sector; changing co-payments; and increasing attention to public comparison of quality and efficiency indicators, the value of investments in health care and responsiveness to patients needs. Reforms are often introduced on the local level, thus the pattern of reform varies across local government, although mimicking behaviour usually occurs.
TL;DR: In this paper, a special issue explores to what extent policies and institutions of the European Union spread across different contexts, and what are the mechanisms of, and scope conditions for, their diffusion; and the scope conditions which are likely to affect domestic (or regional) change in response to the promotion or emulation of EU ideas and institutions.
Abstract: This special issue explores to what extent policies and institutions of the European Union spread across different contexts. Are the EU's attempts to transfer its policies and institutions to accession and neighbourhood countries sustainable and effective? To what degree do other regions of the world emulate the EU's institutional features; what are the mechanisms of, and scope conditions for, their diffusion? This introduction provides the conceptual framework of the special issue. First, it specifies EU-related institutional change as the ‘dependent variable’. Second, it discusses how Europeanisation research and diffusion studies relate to each other and can be fruitfully combined to identify processes and mechanisms by which ideas and institutions of the EU spread. Third, we introduce scope conditions which are likely to affect domestic (or regional) change in response to the promotion or emulation of EU ideas and institutions.
TL;DR: In this article, the relevant literature describing innovative organizational approaches in the management of used tyres in the European Union member countries and the possible uses of waste tyres as a source of raw materials or alternative fossil fuels are presented.
TL;DR: Older women show the greatest falls in breast cancer mortality rates in the EU (-17%), and declines are expected in all individual countries, except Poland.
TL;DR: In this article, the export competitiveness of the European Union has been affected by environmental regulation and innovation, and a theoretically based gravity model applied to the export dynamics of five aggregated manufacturing sectors classified by their technological or environmental content.
TL;DR: Overall, the EU displaced all three types of environmental pressures to the rest of the world, through imports of products with embodied pressures, while the UK was the most important displacer overall and the largest net exporters of embodied environmental pressures were Poland, France, and Spain.
Abstract: A nation’s consumption of goods and services causes various environmental pressures all over the world due to international trade. We use a multiregional input–output model to assess three kinds of environmental footprints for the member states of the European Union. Footprints are indicators that take the consumer responsibility approach to account for the total direct and indirect effects of a product or consumption activity. We quantify the total environmental pressures (greenhouse gas emissions: carbon footprint; appropriation of biologically productive land and water area: land footprint; and freshwater consumption: water footprint) caused by consumption in the EU. We find that the consumption activities by an average EU citizen in 2004 led to 13.3 tCO2e of induced greenhouse gas emissions, appropriation of 2.53 gha (hectares of land with global-average biological productivity), and consumption of 179 m3 of blue water (ground and surface water). By comparison, the global averages were 5.7 tCO2e, 1.23...
TL;DR: This report presents a highly sensitive, rhodamine B-covered gold nanoparticle (RB-AuNP) -based assay with dual readouts (colorimetric and fluorometric) for detecting organophosphorus and carbamate pesticides in complex solutions.
Abstract: This report presents a highly sensitive, rhodamine B-covered gold nanoparticle (RB-AuNP) -based assay with dual readouts (colorimetric and fluorometric) for detecting organophosphorus and carbamate pesticides in complex solutions. The detection mechanism is based on the fact that these pesticides can inhibit the activity of acetylcholinesterase (AChE), thus preventing the generation of thiocholine (which turns the RB-AuNP solutions blue and unquenches the fluorescence of RB simultaneously). The color of the RB-AuNP solution remains red and the fluorescence of RB remains quenched. By use of this dual-readout assay, the lowest detectable concentrations for several kinds of pesticides including carbaryl, diazinon, malathion, and phorate were measured to be 0.1, 0.1, 0.3, and 1 μg/L, respectively, all of which are much lower than the maximum residue limits (MRL) as reported in the European Union pesticides database as well as those from the U.S. Department Agriculture (USDA). This assay allows detection of pe...
TL;DR: Empirical results show that geographical, organizational and institutional proximity favour collaborations, while cognitive and social proximity do not play a significant role.
Abstract: Balland P.-A. Proximity and the evolution of collaboration networks: evidence from research and development projects within the global navigation satellite system (GNSS) industry, Regional Studies. This paper analyses the influence of proximity on the evolution of collaboration networks. It determines empirically how organizations choose their partners according to their geographical, cognitive, organizational, institutional and social proximity. Relational databases are constructed from research and development collaborative projects, funded under the European Union 6th Framework Programme within the global navigation satellite system (GNSS) industry from 2004 to 2007. The stochastic actor-based model SIENA is used to model the network dynamic as a realization of a continuous-time Markov chain and to estimate parameters for underlying mechanisms of its evolution. Empirical results show that geographical, organizational and institutional proximity favour collaborations, while cognitive and social proximit...
TL;DR: An overview of EUROMOD components is provided, covering its policy scope, the input data, the validation process and some technical aspects such as the tax-benefit programming language and the user interface.
Abstract: This paper aims to provide an introduction to the current state of the art of EUROMOD, the European Union tax-benefit microsimulation model. It explains the original motivations for building a multi-country EU-wide model and summarises its current organisation. It provides an overview of EUROMOD components, covering its policy scope, the input data, the validation process and some technical aspects such as the tax-benefit programming language and the user interface. The paper also reviews some recent applications of EUROMOD and, finally, considers future developments.