Showing papers on "Thalamus published in 1984"

The density and distribution of ischemic brain injury in the rat following 2–10 min of forebrain ischemia

Abstract: The density and distribution of brain damage after 2-10 min of cerebral ischemia was studied in the rat. Ischemia was produced by a combination of carotid clamping and hypotension, followed by 1 week recovery. The brains were perfusion-fixed with formaldehyde, embedded in paraffin, subserially sectioned, and stained with acid fuchsin/cresyl violet. The number of necrotic neurons in the cerebral cortex, hippocampus, and caudate nucleus was assessed by direct visual counting. Somewhat unexpectedly, mild brain damage was observed in some animals already after 2 min, and more consistently after 4 min of ischemia. This damage affected CA4 and CA1 pyramids in the hippocampus, and neurons in the subiculum. Necrosis of neocortical cells began to appear after 4 min and CA3 hippocampal damage after 6 min of ischemia, while neurons in the caudoputamen were affected first after 8-10 min. Selective neuronal necrosis of the cerebral cortex worsened into infarction after higher doses of insult. Damage was worst over the superolateral convexity of the hemisphere, in the middle laminae of the cerebral cortex. The caudate nucleus showed geographically demarcated zones of selective neuronal necrosis, damage to neurons in the dorsolateral portion showing an all-or-none pattern. Other structures involved included the amygdaloid, the thalamic reticular nucleus, the septal nuclei, the pars reticularis of the substantia nigra, and the cerebellar vermis.

The origin of thalamic inputs to the arcuate premotor and supplementary motor areas

Abstract: We have used retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase to examine the origin of thalamic input to the two premotor areas with the densest projections to the motor cortex: the arcuate premotor area (APA) and the supplementary motor area (SMA) Retrograde transport demonstrated that the two premotor areas and the motor cortex each receive thalamic input from separate, cytoarchitectonically well defined subdivisions of the ventrolateral thalamus According to the nomenclature of Olszewski (Olszewski, J (1952) The Thalamus of the Macaca mulatta An Atlas for Use with the Stereotaxic Instrument, S Karger, AG, Basel), input to the APA originates largely from area X, input to the SMA originates largely from the pars oralis subdivision of nucleus ventralis lateralis (VLo), and that to the motor cortex originates largely from the pars oralis subdivision of nucleus ventralis posterior lateralis (VPLo) These observations, when combined with prior studies on the termination of various subcortical efferents in the thalamus, lead to the following scheme of connections: (1) rostral portions of the deep cerebellar nuclei project to the motor cortex via VPLo; (2) caudal portions of the deep cerebellar nuclei project to the APA via area X; and (3) the globus pallidus projects to the SMA via VLo Thus, each thalamocortical pathway is associated with a distinct subcortical input

Electrophysiology of neurons of lateral thalamic nuclei in cat: resting properties and burst discharges

Abstract: Intracellular and extracellular recordings were performed in lateral thalamic nuclei (ventroanterior-ventrolateral, ventroposterolateral, centralis, lateralis, and reticularis) of cats under barbit...

Quantitative autoradiography of beta 1- and beta 2-adrenergic receptors in rat brain

Abstract: We have used quantitative autoradiography to localize in rat brain beta 1- and beta 2-adrenergic receptors. These receptors were labeled in vitro with 125I-labeled pindolol, an antagonist of beta-adrenergic receptors that binds nonselectively to both beta 1 and beta 2 subtypes. The selective inhibition of 125I-labeled pindolol binding with specific antagonists of beta 1 and beta 2 receptors allowed the visualization of beta-adrenergic receptor subtypes. High levels of beta 1 receptors were observed in the cingulate cortex, layers I and II of the cerebral cortex, the hippocampus, the Islands of Calleja, and the gelatinosus, mediodorsal, and ventral nuclei of the thalamus. High levels of beta 2 receptors were found in the molecular layer of the cerebellum, over pia mater, and in the central, paraventricular, and caudal lateral posterior thalamic nuclei. Approximately equal levels of beta 1 and beta 2 receptors occurred in the substantia nigra, the olfactory tubercle, layer IV of the cerebral cortex, the medial preoptic nucleus, and all nuclei of the medulla. The pronounced differences in the ratio of beta 1 to beta 2 receptors among brain regions suggests that the subtypes of beta-adrenergic receptors may play different roles in neuronal function.

Subcortical projections of area MT in the macaque.

Abstract: Area MT is a visuotopically organized area in extrastriate cortex of primates that appears to be specialized for the analysis of visual motion. To examine the full extent and topographic organization of the subcortical projections of MT in the macaque, we injected tritiated amino acids in five cynomolgus monkeys and processed the brains for autoradiography. The injection sites, which we identified electrophysiologically, ranged from the representation of central through peripheral vision in both the upper and lower visual fields and included, collectively, most of MT. Projections from MT to the superior colliculus are topographically organized and in register with projections from striate cortex to the colliculus. Unlike projections from striate cortex, those from MT are not limited to the upper layer of the stratum griseum superficiale but rather extend ventrally from the upper through the lower layer of the stratum griseum superficiale and even include the stratum opticum. Projections from MT to the pulvinar are organized into three separate fields. One field (P1) is located primarily in the inferior pulvinar but extends into a portion of the adjacent lateral pulvinar. The second field (P2) partially surrounds the first and is located entirely in the lateral pulvinar. The third and heaviest projection field (P3) is located posteromedially in the inferior pulvinar but also includes small portions of the lateral and medial pulvinar that lie dorsal to the brachium of the superior colliculus. While projections from MT to P1 and P2 are topographically organized, there appears to be a convergence of MT inputs to P3. Projections from MT to the reticular nucleus of the thalamus are located in the ventral portion of the nucleus, approximately at the level of the caudal pulvinar. There was some evidence that MT sites representing central vision project more caudally than do those representing peripheral vision. Projections from MT to the caudate, putamen, and claustrum are localized to small, limited zones in each structure. Those to the caudate terminate within the most caudal portion of the body and the tail. Similarly, projections to the putamen are always to its most caudal portion, where the structure appears as nuclear islands. Projections to the claustrum are located ventrally, approximately at the level of the anterior part of the dorsal lateral geniculate nucleus. Projections from MT to the pons terminate rostrally in the dorsolateral nucleus, the lateral nucleus, and the dorsolateral portion of the peduncular nucleus.(ABSTRACT TRUNCATED AT 400 WORDS)

Presynaptic Nicotinic Cholinergic Receptors Labeled by [3H]Acetylcholine on Catecholamine and Serotonin Axons in Brain

Abstract: Nicotinic cholinergic receptor binding sites labeled by [3H]acetylcholine were measured in the cerebral cortices, thalami, striata, and hypothalami of rats lesioned by intraventricular injection of either 6-hydroxydopamine or 5,7-dihydroxytryptamine. In addition, [3H]acetylcholine binding sites were measured in the cerebral cortices of rats lesioned by injection of ibotenic acid into the nucleus basalis magnocellularis. [3H]Acetylcholine binding was significantly decreased in the striata and hypothalami of both 6-hydroxydopamine-and 5,7-dihydroxytryptamine-lesioned rats. There was no change in binding in the cortex or thalamus by either lesion. Ibotenic acid lesions of the nucleus basalis magnocellularis, which projects cholinergic axons to the cortex, did not alter [3H]acetylcholine binding. These results provide evidence for a presynaptic location of nicotinic cholinergic binding sites on catecholamine and serotonin axons in the striatum and hypothalamus.

Thalamic connections of the insula in the rhesus monkey and comments on the paralimbic connectivity of the medial pulvinar nucleus

Abstract: Thalamic connections of the insula in the rhesus monkey were studied with axonal transport methods. Tritiated amino acid injections limited to the insula revealed autoradiographic label in the principal and parvicellular components of the ventroposterior medial nucleus, the ventroposterior inferior nucleus, the oral and medial pulvinar nuclei, the nucleus reuniens, the parvicellular and magnocellular components of the medial dorsal nucleus, the centromedian-parafasicularis nuclei, and the reticular nucleus. In additional animals, tritiated amino acids and horseradish perioxidase injections were made within different regions of the insula. Although the injection sites in these additional cases may have included minor extensions into claustrum and adjacent structures, several tentative conclusions emerged with respect to the antero-posterior gradient in insulothalamic connectivity. The anterior insula appears to have a more extensive relationship with the ventroposterior medial complex, the medial dorsal nucleus, the centromedian-parafasicularis nuclei and with some midline nuclei. In contrast, the posterior insula is more extensively connected with the ventroposterior inferior nucleus, the oral and medial pulvinar nuclei, and the suprageniculate nucleus. The patterns of insulothalamic connections support conclusions derived from observations on the cortical connectivity of the primate insular cortex indicating that the anterior insula is related to olfactory, gustatory, and viscero-autonomic behavior, whereas the posterior insula is related to auditory-somesthetic-skeletomotor function (Mesulam and Mufson, '82b). The medial pulvinar nucleus has extensive connections with many paralimbic cortical regions including the insula as well as with high order polymodal association cortex. These findings suggest that the medial pulvinar may provide a region for the convergence of multisensory association input with limbic information.

Thalamic projections of nucleus reticularis thalami of cat : a study using retrograde transport of horseradish peroxidase and fluorescent tracers

Abstract: The retrograde transport of horseradish peroxidase (HRP) and fluorescent tracers after injections in various thalamic nuclei was used to investigate the relative density of retrogradely labeled cells in different districts of reticularis thalami (RE) nuclear complex of cat. The RE nucleus was left virtually free of labeling only after injections localized into the anterior nuclear group; in those experiments, heavy retrograde labeling was obtained in mammillary nuclei. The major targets of RE cells proved to be centralis lateralis-paracentralis (CL-PC) and centrum medianum-parafascicularis (CM-PF) intralaminar nuclei. The projections to various intralaminar nuclei mainly arise in the rostral pole and rostrolateral part of RE nucleus and are reciprocal to intralaminar-RE pathways disclosed by Jones ('75). The RE territories labeled following injections in relay and associational nuclei are more restricted and are located contiguously and slightly anteriorly to a given nucleus. There was a very small proportion of doubly labeled RE cells after injections with fluorescent tracers in different nuclei. This was not due to a technical failure since many double-labeled neurons were found in the same material in medial globus pallidum after thalamic and midbrain injections (see companion paper by Parent and Steriade, '84). We conclude that most individual RE axons arborize in only one thalamic nucleus or nuclear group. An additional finding was the existence of intralaminar-to-relay (CL-PC to VA-VL) projections.

Projections of the amygdala to the thalamus in the cynomolgus monkey.

Abstract: The projections of the amygdala to the thalamus in cynomolgus monkeys (Macaca fascicularis) were studied with both anterograde and retrograde axonal tracing techniques Horseradish peroxidase (HRP) was injected into medial and midline thalamic sites in five animals, and tritiated amino acids were injected into selected amygdaloid regions in a total of 13 hemispheres in ten animals The findings from the two types of tracer experiments demonstrated the origins, course, and terminal pattern of amygdaloid projections to two thalamic nuclei--medialis dorsalis (MD) and reuniens Almost all of the amygdaloid nuclei contribute projections to MD, though the greatest proportion arise from the basal group and terminate in discrete, interlocking patches within the medial, magnocellular portion of MD In addition to this major projection, the central and medial amygdaloid nuclei send a lighter projection to the lateral portion of nucleus reuniens The amygdalothalamic projections took a variety of routes out of the amygdala before the large majority joined the inferior thalamic peduncle and entered the rostral head of the thalamus where they turned caudally toward their targets A small number of amygdalothalamic fibers may also run in the stria terminalis

Heterogeneity of microtubule-associated protein 2 during rat brain development.

Abstract: The electrophoretic pattern of the large microtubule-associated protein, MAP2, changes during rat brain development. Immunoblots of NaDodSO4 extracts obtained from the cerebral cortex, cerebellum, and thalamus at 10-15 days after birth reveal only a single electrophoretic species when probed with any of three MAP2 monoclonal antibodies. By contrast, adult MAP2 contains two immunoreactive species, MAP2a and MAP2b. The single band of MAP2 from immature brain electrophoretically comigrates with adult MAP2b. Between postnatal days 17 and 18, immature MAP2 simultaneously resolves into two species in both the cerebellum and cerebral cortex. Immunoblots of NaDodSO4 extracts from spinal cord demonstrate the adult complement of MAP2 by day 10, indicating that MAP2 does not change coordinately throughout the entire central nervous system. In vitro cAMP-dependent phosphorylation of immature MAP2 causes a band split reminiscent of that seen during brain development in vivo. The possibility that the developmentally regulated changes observed in MAP2 during brain maturation are due to timed phosphorylation events is discussed.

Central Gating Mechanisms That Regulate Event-Related Potentials and Behavior

Abstract: Previous work in our laboratory showed that the mesencephalic reticular formation (MRF) and frontal granular cortex (FC) jointly regulate the activity in the thalamic reticular nucleus (R). The R neurons project specifically into relay nuclei and, when activated, inhibit the specific transmission of sensory information through the thalamus to primary receptive cortex. The MRF has a generalized inhibitory effect on the R cells and can produce generalized disinhibition of sensory channels, as is known to occur during orienting responses. The frontal cortex, on the other hand, provides specific and tonic excitation of individual R cells and can selectively turn off specific sensory channels, as is known to occur during selective attention. Our more recent work has focused on the cellular mechanisms in the frontal cortex that result in the specific sensory gating that occurs during operationally defined states of behavioral attention. The occurrence of the event-related potential (ERSP) in the FC seems to be the harbinger of both EEG desynchronization and sensory channel selection. Both of these latter event-related activities are explainable by FC effects on R cells. We have found that during an ERSP in the FC, in the underlying tissue: (a) norepinephrine (NE) is released, (b) cAMP is activated, (c) extracellular potassium ion activity is reduced, and (d) slow membrane potential shifts occur in some of the neurons. These results suggest that the same neuromodulatory mechanism exists in the cortex as is known to operate in a model preparation, the sympathetic ganglion.

The thalamostriatal projection in the cat

Abstract: The organization of the projections from the intralaminar and other thalamic nuclei to the caudate nucleus (CD), putamen (PU), nucleus accumbens (Acc), and olfactory tubercle (TO) were examined in the cat by autoradiography after deposits of 3H-amino acids in individual thalamic nuclei and by retrograde cell labeling after intrastriatal deposits of wheat-germ-conjugated horseradish peroxidase. All of the rostral intralaminar nuclei, here considered to include the central lateral (CL), paracentral (PC), central medial (CeM), and rhomboid nuclei (Rh), project to the striatum. Projections closely associated with those of the rostral intralaminar group arise from cells of the paraventricular nucleus (PV) and a region lateral to the stria medullaris. These nuclei, which roughly form a ring around the mediodorsal nucleus, project in a highly particular, but loosely arranged topographic pattern to all parts of the striatum. The medially located cells in Rh, PV, and those alongside the stria medullaris project mainly to medial parts of Acc and CD; the dorsolaterally located cells of CL project mainly to the dorsolateral parts of CD and PU; cells in PC and CeM project to progressively more ventral and medial parts of CD and PU, and the lateral part of Acc. Superimposed on this projection from the rostral intralaminar region is the projection from the caudal intralaminar group including the centromedian (CM), parafascicular (PF), and subparafascicular nuclei (subPF). Together these nuclei project in a loosely but specifically organized topography to the entire striatum. The lateral and dorsal parts of CD and PU receive fibers mainly from CM. Ventral and medial parts of CD and PU and Acc receive fibers mainly from PF; TO receives fibers from subPF and the ventral part of PF. Several nuclei in the lateral nuclear mass of the thalamus also project to particular parts of the striatum. Thus, cells in the rostromedial part of the ventral anterior nucleus project to the head of CD and some cells in the rostral part of the ventromedial nucleus project to the head of CD and to PU. Several cells scattered in the lateral posterior complex project to lateral parts of the head of CD, and cells in the rostral extension of the medial subdivision of the posterior nuclear complex project to lateral parts of the head and body of CD. Finally, several cells of the paratenial nucleus project selectively to Acc. These data provide a detailed map of the total thalamostriatal projection in the cat and, hence, form a basis for more specific functional questions about this poorly understood system.

Interruption of the mammillothalamic tract prevents seizures in guinea pigs.

Abstract: Interruption of the connection between the mammillary bodies and the anterior nucleus of the thalamus in guinea pigs, by discrete bilateral electrolytic lesions of the mammillothalamic tract, resulted in essentially complete protection from the behavioral and electroencephalographic convulsant action and lethal effect of pentylenetetrazol. This result demonstrates that the mammillary bodies and their rostral efferent connections are important for the propagation and perhaps initiation of generalized seizures.

Anterior thalamic afferents from the mamillary body and the limbic cortex in the rat.

Abstract: Anterior thalamic afferents from the mamillary body and the limbic cortex were studied by using single and double retrograde transport methods in the rat. The medial mamillary nucleus was divided on the basis of the cytoarchitecture into four subnuclei: the pars medialis centralis, pars medialis dorsalis, pars lateralis, and pars basalis. Extensive connections were seen between each of these subdivisions of the mamillary body and the anterior thalamic nuclei, topographically organized so that the anteromedial thalamic nucleus receives projections exclusively from the pars medialis centralis, while the anteroventral thalamic nucleus receives projections from the pars medialis dorsalis and pars lateralis. Nuclei in the dorsal half of these two mamillary subdivisions project predominantly to the medial half of the anteroventral thalamic nucleus, and those in the ventral half to the lateral half of the nucleus. The pars basalis was found to have numerous projections to the magnocellular part of the anteroventral nucleus. All limbic cortical areas send projections bilaterally to all regions of the anteromedial nucleus as well as to the parvicellular parts of the anteroventral thalamic nucleus, while the anterodorsal nucleus receives ipsilateral projections originating exclusively from the preagranular, anterior limbic, and cingular regions. The magnocellular part of the anteroventral nucleus, however, receives only ipsilateral projections from all of the limbic cortex. Some neurons in the infralimbic region also project bilaterally to all of the anterior thalamic nuclei except the anterodorsal nucleus. All of these cortical projections to the anterior thalamus originate in layers V and VI of the limbic cortex.

Electrophysiology of neurons of lateral thalamic nuclei in cat: mechanisms of long-lasting hyperpolarizations

Abstract: Intracellular recordings were performed in the lateral thalamic nuclei of cats under barbiturate anesthesia. The nature of cyclic hyperpolarizations triggered in relay cells by cortical stimulation...

The ventral pallidal projection to the mediodorsal thalamus: a study with fluorescent retrograde tracers and immunohistofluorescence.

Abstract: We have examined rat basal forebrain projections to the mediodorsal thalamic nucleus (MD) by making injections of retrogradely transported fluorescent tracers into the MD. Additionally, in some animals, we also stained sections for glutamate decarboxylase (GAD) by the indirect fluorescent antibody technique. Our results demonstrate that the following basal forebrain areas project to the MD: lateral orbital cortex, agranular insular cortex superficial to claustrum, primary olfactory cortex, diagonal band nuclei, ventral pallidum, and amygdala. A large number of labeled cells are present in the olfactory tubercle, and these cells are almost without exception located in dense GAD-positive ventral pallidal areas rather than in striatal regions of the tubercle. This ventral pallidal projection to the MD strengthens the concept of a ventral striatal-pallidal system in parallel to the classic striatal-pallidal system which projects to the ventral thalamus. These results are also discussed in relationship to the olfactory system.

The diencephalon in schizophrenia: evidence for reduced thickness of the periventricular grey matter.

Abstract: To find out whether ventricular enlargement in schizophrenia, as demonstrated by neuroradiological methods, is caused by an atrophy of ventricle surrounding diencephalic structures, volume measurements and linear measurements of the whole thalamus, all large thalamic subnuclei and some extrathalamic brain parts were carried out on serial sections of post mortem brains belonging to the Vogt collection. The only significantly diminished parameter of this study was the thickness of the periventricular grey matter surrounding the third ventricle, while the volume and linear measurements of the whole thalamus and all large thalamic subnuclei were not significantly changed. The findings are discussed with respect to current hypotheses of diencephalic dysfunction in schizophrenia.

Telencephalic connections in lizards. I. Projections to cortex.

Abstract: The afferent connections to five cortical regions in two distantly related species of lizards (Gekko gecko and Iguana iguana) were studied by means of retrograde transport of horseradish peroxidase conjugated to wheat germ agglutinin. Each of the five cortical regions is characterized by a specific pattern of projections from telencephalic, thalamic, hypothalamic, and brainstem regions. Subdivisions within the five cortical regions also receive different patterns of projections. The thalamo-cortical projections are as follows: The small-celled mediodorsal cortex receives a projection from nucleus dorsolateralis anterior pars magnocellularis. The large-celled mediodorsal cortex receives projections from nucleus dorsolateralis anterior pars parvicellularis and pars magnocellularis. The dorsal cortex receives a projection from nucleus dorsolateralis anterior pars parvicellularis. The lateral cortex receives a projection from nucleus dorsolateralis anterior pars magnocellularis. The pallial thickening receives projections from nucleus dorsomedialis and nucleus intercalatus. The latter nucleus receives a direct retinal projection. Thus, the pallial thickening is the recipient of a retino-thalamocortical projection. To date, comparisons of data from experimental studies have suggested that the cortical regions in lizards and turtles may be organized differently. However, the results of the present study suggest that the organization of cortical regions among reptiles is more similar than previously realized.

GABA-containing neurons in the thalamus and pretectum of the rodent. An immunocytochemical study.

Abstract: Antisera produced by immunizing rabbits with GABA conjugated to bovine serum albumin reacted, after purification, strongly with GABA fixed with glutaraldehyde to rat brain macromolecules, but insignificantly with other fixed amino acids (Storm-Mathisen et al. 1983). Sections through the diencephalon of perfusion-fixed mouse and rat brains showed a highly selective labeling pattern after incubation with these antisera. All cells of the reticular nucleus appeared to be stained. Smaller proportions of stained perikarya occurred in the dorsal and ventral subdivisions of the lateral geniculate body, in the medial geniculate body, in the lateroposterior nucleus, and in all nuclei of the pretectum. Labeled cell bodies were only rarely encountered in the ventrobasal complex, and were not found in the anterior and medial groups of thalamic nuclei. Stained axons were particularly concentrated in the ventrobasal complex, and in the stria medullaris, stria terminalis and inferior thalamic peduncle. The arrangement and density of labeled boutonlike dots varied markedly among nuclei, the highest densities occurring in the paraventricular and parataenial nuclei, and in the ventral subdivision of the lateral geniculate body. The mean staining intensity of the thalamic neuropil was lower than that of nearby structures, such as the hypothalamus and zona incerta. The present results on direct immunocytochemical detection of GABA are consistent with, and extend, data from immunocytochemical studies of the GABA-synthetizing enzyme, glutamic acid decarboxylase.

Experiments on functional role of peripheral input to motor cortex during voluntary movements in the monkey.

Abstract: The functional role of sensory input to the motor cortex was studied by interrupting two major input pathways. One was the dorsal column, which sends the input directly through the thalamus to the motor cortex, and the other was the sensory cortex, which transfers its input through association fibers. Removal of the sensory cortex produced very little motor disturbances and the function recovered within a week. Section of the dorsal column produced some motor deficit, but the deficit was not severe and the animals recovered nearly completely within 2 wk. Combination of dorsal column section and sensory cortex removal produced severe motor deficits. These consisted of loss of orientation within extrapersonal space and loss of dexterity of individual fingers. These deficits never recovered within the duration of observation, which lasted 4-5 wk. It is concluded that the direct sensory input from the thalamus plays an important role in the control of voluntary movements, but loss of its function can be compensated by the input from the sensory cortex. The possible neuronal basis for the observed motor deficits is discussed and it is proposed that the sensory input functions by selectively changing the excitability of cortical efferent zones before and during the execution of voluntary movements. Recovery of motor function following dorsal column section occurred in parallel with the recovery of sensory input to the motor cortex. The recovered function and sensory input disappeared again following section of the association fibers from the sensory cortex. Neuronal mechanism for this observation is also discussed.

The Basal ganglia : structure and function

Abstract: Anatomy of the System - Interconnections, Inputs And Outputs.- Interconnections Between the Corpus Striatum and Brain Stem Nuclei.- Thalamostriate Projections - an Overview.- The Primate Striato-Pallido-Nigral System: An Integrative System for Cortical Information.- The Termination of Striatonigral fibres on Nigrotectal Neurons in the Rat - A Preliminary Report.- Serotoninergic Innervation of the Monkey Basal Ganglia: An Immunocytochemical, Light and Electron Microscopy Study.- Fluorescent Double Labeling Studies of Thalamostriatal and Corticostriatal Neurons.- The Output Organization of the Pallidum and Substantia Nigra in Primate as Revealed by a Retrograde Double-Labeling Method.- Neural Mechanisms - Synaptic Actions, Transmitters and Receptors, Output Mechanisms.- Dopamine Decreases the Amplitude of Excitatory Post-Synaptic Potentials in Rat Striatal Neurones.- Presynaptic Actions and Dopamine in the Neostriatum.- Anatomy and Neurophysiology of the Subthalamic Efferent Neurons.- Neural Activity in Basal Ganglia Output Nuclei and Induced Hypermotility.- Tonic Nigral Control of Tecto Spinal/Tecto Diencephalic Branched Neurons: A Possible Implication of Basal Ganglia in Orienting Behavior.- Basal Ganglia Transmitters And Receptors.- The Regulation of Striatal Dopamine Receptors: Subsensitivity Induced by Hyperthyroidism or REM Sleep Deprivation.- Can Enzymes Released from the Nigro-Striatal Pathway Act as Neuromodulators?.- Functions of the Basal Ganglia in Posture, Movement and Behaviour.- Diseases of the Basal Ganglia.- Long Latency Reflexes in Patients with Basal Ganglia Disorders.- Motor Effects Produced by Disruption of Basal Ganglia Output to the Thalamus.- Unilateral Electrolytic and 6-OHDA Lesions of the Substantia Nigra in Baboons: Behavioural and Biochemical Data.- Postural and Behavioural Changes Related to Nigral Cell Loss in Monkeys.- Neurobiological Changes Induced by Neostriatal Kainic Acid Injection An Electrophysiological and Morphological Approach to the Physiopathology of Huntington's Chorea.- Dopamine Neurone Degeneration-like Deficits Produced by Intrahypothalamic Dopamine Injections.- Output Pathways Mediating Basal Ganglia Function.- Responses of Neurons in Different Regions of the Striatum of the Behaving Monkey.- Consequences of Disturbed GABA-Ergic Transmission in Substantia Nigra Pars Reticulata in Freely Moving Cats on their Motor Behaviour, and in Anaesthetized Cats on their Spinal Motor Elements.- Basal Ganglia and Switching Motor Programs.- Structure and Function of the Basal Ganglia: A Point of View.- Symposium Participants.