John P. Quinn

TL;DR: These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified.

TL;DR: Two examples of the action of estrogen on central neurotransmission are discussed in terms of their immediate clinical importance for the treatment of depressive symptoms, their use as powerful models for investigations on the steroid control of central neurotransmitter mechanisms, and the role of estrogen as “Nature's” psychoprotectant.

TL;DR: The data suggest that these polymorphic variable number of tandem repeats regions act as transcriptional regulators and have allele-dependent differential enhancer-like properties within an area of the hindbrain where the 5-HTT gene is known to be transcribed at this stage of development.

TL;DR: It is demonstrated that this region of the VNTR domain will support differential levels of reporter gene expression in differentiating embryonic stem cells, this being dependent on the presence of 10 or 12 copies of the repeat.

TL;DR: This genome-wide association study using 1,636 cases of depression ascertained in the U.K. and comparison subjects screened negative for psychiatric disorders suggests that individual gene contributions to depression are likely to have only minor effects, and very large pooled analyses will be required to identify them.