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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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Journal ArticleDOI
The BH3-only protein Puma plays an essential role in cytokine deprivation-induced apoptosis of mast cells
Maria Ekoff,Thomas Kaufmann,Maria Engström,Noboru Motoyama,Andreas Villunger,Jan-Ingvar Jönsson,Andreas Strasser,Gunnar Nilsson +7 more
TL;DR: It is demonstrated that Puma is critical for the induction of mast-cell death following cytokine deprivation and treatment with the DNA-damaging agent etoposide in MLMCs and CTLMCs, and suggested a plausible role for Puma in the regulation of mast cell numbers in vivo.
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Intrahepatic murine CD8 T cell activation associates with a distinct phenotype leading to Bim-dependent death
Lauren E. Holz,Volker Benseler,Volker Benseler,David G. Bowen,Philippe Bouillet,Andreas Strasser,Lorraine A. O'Reilly,W. d’Avigdor,Alex Bishop,Geoffrey W. McCaughan,Patrick Bertolino +10 more
TL;DR: This study identifies Bim for the first time as a critical initiator of T-cell death in the liver, and strategies inhibiting the up-regulation of this molecule could potentially be used to rescue CD8 T cells, clear the virus, and reverse the outcome of viral chronic infections affecting the liver.
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Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
Silke F. Fischer,Philippe Bouillet,Kristy O'Donnell,Amanda Light,David M. Tarlinton,Andreas Strasser +5 more
TL;DR: This study has identified for the first time the physiologic mechanisms for killing low-affinity antibody-expressing B cells in an immune response and has shown this to be dependent on the BH3-only protein Bim.
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Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax
Mark D. McKenzie,Emma Jamieson,Elisa S. Jansen,Clare L. Scott,David C.S. Huang,Philippe Bouillet,Janette Allison,Thomas W.H. Kay,Andreas Strasser,Helen E. Thomas +9 more
TL;DR: These results implicate the Bcl-2 regulated apoptotic pathway in glucose-induced islet cell killing and indicate points in the pathway at which interventional strategies can be designed.
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The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
Thomas Pohl,Raffi Gugasyan,Raelene J. Grumont,Andreas Strasser,Donald Metcalf,David M. Tarlinton,William C. Sha,David Baltimore,Steve Gerondakis +8 more
TL;DR: It is demonstrated that in the B lineage overlapping roles for NF-κB1 and c-Rel appear to be restricted to regulating the activation and function of mature cells.