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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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Journal ArticleDOI
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias
Rachel Thijssen,Rachel Thijssen,Sarah T. Diepstraten,Sarah T. Diepstraten,Donia M Moujalled,Edward Chew,Christoffer Flensburg,Christoffer Flensburg,Melissa X Shi,Michael A. Dengler,Michael A. Dengler,Michael A. Dengler,Veronique Litalien,Sarah MacRaild,Maoshan Chen,Natasha S Anstee,Natasha S Anstee,Boris Reljic,Boris Reljic,Sarah S. Gabriel,Tirta Mario Djajawi,Chris D. Riffkin,Brandon J. Aubrey,Brandon J. Aubrey,Catherine Chang,Lin Tai,Zhen Xu,Zhen Xu,Thomas David Morley,Giovanna Pomilio,Claudia Bruedigam,Claudia Bruedigam,Axel Kallies,David A. Stroud,Ashish Bajel,Ruth M. Kluck,Ruth M. Kluck,Steven W. Lane,Steven W. Lane,Marie Schoumacher,Sébastien Banquet,Ian J. Majewski,Ian J. Majewski,Andreas Strasser,Andreas Strasser,Andrew W. Roberts,David C. S. Huang,David C. S. Huang,Fiona C. Brown,Gemma L. Kelly,Gemma L. Kelly,Andrew H. Wei,Andrew H. Wei +52 more
TL;DR: In this paper, the authors reveal the key role of TP-53 in shaping long-term responses to BH3-mimetic drugs and reconcile the disparate pattern of initial clinical response to venetoclax, followed by subsequent treatment failure among patients with TP53-mutant chronic lymphocytic leukemia or acute myeloid leukemia.
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Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
Jack Hutcheson,John C. Scatizzi,Emily Bickel,Nathaniel J. Brown,Philippe Bouillet,Andreas Strasser,Harris Perlman +6 more
TL;DR: Thymocytes isolated from Bak+/−Bim−/− or Bax/Bim +/− mice are markedly more resistant to apoptotic stimuli mediated by the intrinsic pathway as compared with thymocytes from single-knockout mice, suggesting an essential overlapping role for Bak or Bx and Bim in the intrinsic apoptotic pathway.
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Discovery and molecular characterization of a Bcl-2–regulated cell death pathway in schistosomes
Erinna F. Lee,Oliver B. Clarke,Marco Evangelista,Zhi-Ping Feng,Terence P. Speed,Elissaveta B Tchoubrieva,Andreas Strasser,Bernd H. Kalinna,Peter M. Colman,W. Douglas Fairlie +9 more
TL;DR: The identification and characterization of a Bcl-2–regulated apoptosis pathway in Schistosoma japonicum and S. mansoni is described and it is shown that a schistosome prosurvival protein, sjA, binds ABT-737, a well-characterized BH3 mimetic.
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Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals
Paul G. F. Koenen,Susanne Heinzel,Susanne Heinzel,Emma M. Carrington,Emma M. Carrington,Lina Happo,Lina Happo,Warren S. Alexander,Warren S. Alexander,Jian-Guo Zhang,Jian-Guo Zhang,Marco J Herold,Marco J Herold,Clare L. Scott,Clare L. Scott,Andrew M. Lew,Andrew M. Lew,Andreas Strasser,Andreas Strasser,Philip D. Hodgkin,Philip D. Hodgkin +20 more
TL;DR: The results identify a molecular switch that can serve as an attractive target for inducing antigen-specific tolerance in treating autoimmune disease patients and transplant recipients.
Journal ArticleDOI
BCL-2: Long and winding path from discovery to therapeutic target.
TL;DR: The long and winding path from the discovery of this protein and understanding the fundamental process of apoptosis that BCL-2 and its numerous homologues control, through to its exploitation as a drug target that is set to have significant benefit for cancer patients is described.