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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner
Nathalie Cambier,Rajesh Chopra,Andreas Strasser,Donald Metcalf,Andrew G. Elefanty,Andrew G. Elefanty +5 more
TL;DR: A dose-dependent hierarchy of BCR – ABL induced biological effects is established, thus distinguishing the activation of pathways mediating protection from cytokine withdrawal from those protecting against other apoptotic stimuli.
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BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival.
Erinna F. Lee,Tiffany J Harris,Sharon Tran,Marco Evangelista,Surein Arulananda,Thomas John,Celeste Ramnac,Chloe Hobbs,Haoran Zhu,Haoran Zhu,Gency Gunasingh,David J. Segal,Andreas Behren,Jonathan Cebon,Alexander Dobrovic,John M. Mariadason,Andreas Strasser,Andreas Strasser,Leona Rohrbeck,Leona Rohrbeck,Nikolas K. Haass,Marco J Herold,Marco J Herold,W. Douglas Fairlie +23 more
TL;DR: The data show for the first time that therapies targeting specific combinations of BCL-2 pro-survival proteins, namely MCL-1 plus B CL-XL and Mcl-1plus BCLs2, could have significant benefit for the treatment of melanoma.
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Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.
Leigh Coultas,Philippe Bouillet,Edouard G. Stanley,Thomas C. Brodnicki,Jerry M. Adams,Andreas Strasser +5 more
TL;DR: The results indicate that any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only proteins.
Journal ArticleDOI
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
TL;DR: Results demonstrate that UVR activates the Bcl-2–regulated apoptotic pathway predominantly through activation of Noxa and, depending on cellular context, Puma.
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Fas Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38 Mitogen-activated Protein Kinase: Regulators of Distinct Cell Death and Survival Pathways in Granulocytes
TL;DR: It is suggested that G-CSF promotes granulocyte survival largely through the Bcl-2–controlled pathway, whereas CD95 regulates a distinct pathway to apoptosis that is not required for either their spontaneous or drug-induced death.