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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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Journal ArticleDOI
Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway
Caoimhín G. Concannon,B F Koehler,B F Koehler,Claus Reimertz,Brona M. Murphy,Caroline Bonner,N. Thurow,Manus W. Ward,Andreas Villunger,Andreas Strasser,Donat Kögel,Jochen H. M. Prehn +11 more
TL;DR: It is suggested that p53 activation and the transcriptional induction of its target gene PUMA play an important role in the sensitivity of cancer cells to apoptosis induced by proteasome inhibition, and imply that antineoplastic therapies with PIs might be especially useful in cancers with functional p53.
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The role of the apoptotic machinery in tumor suppression.
Alex R. D. Delbridge,Alex R. D. Delbridge,Liz J. Valente,Liz J. Valente,Andreas Strasser,Andreas Strasser +5 more
TL;DR: The processes by which some of these prominent tumor suppressors trigger apoptotic cell death are discussed and how this process protects us from cancer development is discussed.
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Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.
Mark D. McKenzie,Emma M. Carrington,Thomas Kaufmann,Andreas Strasser,David C.S. Huang,Thomas W.H. Kay,Janette Allison,Helen E. Thomas +7 more
TL;DR: Results demonstrate that Bid is essential for death receptor–induced apoptosis of islets, similar to its demonstrated role in hepatocytes, and indicates that blocking Bid activity may be useful for protection of islet from immune-mediated attack and possibly also in other pathological states in which β-cells are destroyed.
Journal ArticleDOI
Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9.
Vanessa S. Marsden,Paul G Ekert,Mark F. van Delft,David L. Vaux,Jerry M. Adams,Andreas Strasser +5 more
TL;DR: It is suggested that caspases other than caspase 2 and 9 can promote cytochrome c release and initiate Bcl-2–regulated apoptosis, and lymphocytes and fibroblasts lacking both remained sensitive to diverse apoptotic stimuli.
Journal ArticleDOI
Transforming Growth Factor β-Dependent Sequential Activation of Smad, Bim, and Caspase-9 Mediates Physiological Apoptosis in Gastric Epithelial Cells
Masatoshi Ohgushi,Shunsuke Kuroki,Hiroshi Fukamachi,Lorraine A. O'Reilly,Keisuke Kuida,Andreas Strasser,Shin Yonehara +6 more
TL;DR: It is indicated for the first time that TGF-β is involved in the physiological loss of gastric epithelial cells by activating apoptosis mediated by Smad, Bim, and caspase-9.