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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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Journal ArticleDOI
Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53.
Liz J. Valente,Stephanie Grabow,Stephanie Grabow,Cassandra J. Vandenberg,Cassandra J. Vandenberg,Andreas Strasser,Andreas Strasser,Ana Janic,Ana Janic +8 more
TL;DR: Results demonstrate that even in the context of deregulated c-MYC expression, p53 must suppress tumor development by activating processes apart from, or in addition to, PUMA-mediated apoptosis and p21-induced cell cycle arrest.
Journal ArticleDOI
Enhanced cell survival and tumorigenesis.
Suzanne Cory,Andreas Strasser,Tyler Jacks,Lynn M. Corcoran,Thomas Metz,A W Harris,Jerry M. Adams +6 more
Journal ArticleDOI
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.
Elisha de Valle,Elisha de Valle,George Grigoriadis,George Grigoriadis,Lorraine A. O'Reilly,Lorraine A. O'Reilly,Simon N. Willis,Simon N. Willis,Mhairi J Maxwell,Lynn M. Corcoran,Lynn M. Corcoran,Evelyn Tsantikos,Jasper K.S. Cornish,Jasper K.S. Cornish,Kirsten A. Fairfax,Kirsten A. Fairfax,Ajithkumar Vasanthakumar,Ajithkumar Vasanthakumar,Mark A. Febbraio,Margaret L. Hibbs,Marc Pellegrini,Marc Pellegrini,Ashish Banerjee,Philip D. Hodgkin,Philip D. Hodgkin,Axel Kallies,Axel Kallies,Fabienne Mackay,Andreas Strasser,Andreas Strasser,Steve Gerondakis,Raffi Gugasyan,Raffi Gugasyan +32 more
TL;DR: It is shown that, with age, NFκB1-deficient B cells spontaneously secrete IL-6 and cause a multiorgan autoimmune disease.
Journal ArticleDOI
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Selma Tuzlak,Selma Tuzlak,Robyn L Schenk,Robyn L Schenk,Ajithkumar Vasanthakumar,Ajithkumar Vasanthakumar,Simon Preston,Simon Preston,Manuel D. Haschka,Dimitra Zotos,Dimitra Zotos,Axel Kallies,Axel Kallies,Andreas Strasser,Andreas Strasser,Andreas Villunger,Marco J Herold,Marco J Herold +17 more
TL;DR: Functional redundancy of A1 with other pro-survival BCL-2 family members in the control of T cell-dependent immune responses is suggested.
Journal ArticleDOI
Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis.
TL;DR: Results show that Bax has a predominant and Bak a minor role in cytokine deprivation-induced apoptosis in both connective tissue-like and mucosal-like mast cells.