A
Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
Papers
More filters
Journal ArticleDOI
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
Stephen Malin,Shane McManus,César Cobaleda,César Cobaleda,Maria Novatchkova,Alessio Delogu,Alessio Delogu,Philippe Bouillet,Andreas Strasser,Meinrad Busslinger +9 more
TL;DR: It is demonstrated that the development of pro-B cells was restored by transgenic expression of the prosurvival protein Bcl-2, which compensated for loss of the antiapoptotic protein Mcl-1.
Journal ArticleDOI
B Lymphocytes Differentially Use the Rel and Nuclear Factor κB1 (NF-κB1) Transcription Factors to Regulate Cell Cycle Progression and Apoptosis in Quiescent and Mitogen-activated Cells
Raelene J. Grumont,Ian J. Rourke,Lorraine A. O'Reilly,Andreas Strasser,Kensuke Miyake,William C. Sha,Steve Gerondakis +6 more
TL;DR: Collectively, these results are the first to demonstrate that in normal B cells, NF-κB1 regulates survival of cells in G0, whereas mitogenic activation induced by distinct stimuli requires different Rel/NF-κBs factors to control cell cycle progression and prevent apoptosis.
Journal ArticleDOI
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity.
Peter Hughes,Gabrielle T. Belz,Karen A. Fortner,Ralph C. Budd,Andreas Strasser,Philippe Bouillet +5 more
TL;DR: These results identify critical overlapping roles for Fas and Bim in T cell death in immune response shutdown and prevention of immunopathology and thereby resolve a long-standing controversy.
Journal ArticleDOI
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
TL;DR: Bim is dispensable for viral clearance but is necessary for the death of activated T cells when immune responses are terminated, which has implications for the therapeutic manipulation of immune responses to infections and immunization.
Journal ArticleDOI
The role of the Bcl-2 protein family in cancer.
Leigh Coultas,Andreas Strasser +1 more
TL;DR: Current knowledge of the molecular control of cell death is described and the role of pro- and anti-apoptotic members of the Bcl-2 protein family in tumourigenesis andAnti-cancer therapy is discussed.