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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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Journal ArticleDOI
Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.
Anissa Jabbour,Carmel Patricia Daunt,Benjamin D Green,Sandra Vogel,Lavinia Gordon,Rachel S. Lee,Natasha Silke,Richard B. Pearson,Cassandra J. Vandenberg,Priscilla N. Kelly,Stephen L. Nutt,Andreas Strasser,Christoph Borner,Paul G Ekert +13 more
TL;DR: It is concluded that p53 protein is activated after IL-3 deprivation by loss of MDM2, which transcriptionally up-regulates Puma, which initiates apoptosis, which is critical for p53-mediated cell-cycle arrest.
Journal ArticleDOI
Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.
C. Clybouw,Delphine Merino,Delphine Merino,T. Nebl,T. Nebl,Frederick Masson,Frederick Masson,Mikara Robati,Mikara Robati,Lorraine A. O'Reilly,Lorraine A. O'Reilly,A. Hubner,Roger J. Davis,Andreas Strasser,Andreas Strasser,Philippe Bouillet,Philippe Bouillet +16 more
TL;DR: The physiological regulation of Bim relies on mechanisms independent of its alternative splicing or the Erk-dependent phosphorylation of BIMEL, and it is concluded that BimEL and BimL are interchangeable, and that BIMS is dispensable for the function of Bims.
Journal ArticleDOI
The role of the pro-apoptotic Bcl-2 family member bim in physiological cell death.
Philippe Bouillet,David C.S. Huang,Lorraine A. O'Reilly,Hamsa Puthalakath,Liam O'Connor,Suzanne Cory,Jerry M. Adams,Andreas Strasser +7 more
TL;DR: It is demonstrated that the Bim gene is disrupted in the mouse and plays a major and non‐redundant role in embryogenesis, in the control of hematopoietic cell death, and as a barrier against autoimmunity.
Journal ArticleDOI
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death.
TL;DR: It is reported that mast cells lacking caspase-9 or Apaf-1 are refractory to apoptosis after cytotoxic insults but still lose effector function and ability to proliferate, indicating that the Apf-1/caspases-9-independent apoptotic pathway observed in lymphocytes is ineffective in cytokine-deprived mast cells.
Journal ArticleDOI
BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.
Zhen Xu,Zhen Xu,Phillip P. Sharp,Phillip P. Sharp,Phillip P. Sharp,Yuan Yao,Yuan Yao,Yuan Yao,David J. Segal,David J. Segal,C H Ang,C H Ang,Seong Lin Khaw,Seong Lin Khaw,Seong Lin Khaw,Brandon J. Aubrey,Brandon J. Aubrey,Brandon J. Aubrey,Jia-Nan Gong,Jia-Nan Gong,Gemma L. Kelly,Gemma L. Kelly,Marco J Herold,Marco J Herold,Andreas Strasser,Andreas Strasser,Andrew W. Roberts,Warren S. Alexander,Warren S. Alexander,Christopher J. Burns,Christopher J. Burns,David C.S. Huang,David C.S. Huang,Stefan P Glaser,Stefan P Glaser +34 more
TL;DR: Certain normal hematopoietic cells, especially those of lymphoid origin, are as prone to apoptosis induced by the BET inhibitors as their transformed counterparts, indicating that their susceptibility to BET inhibitors did not arise from oncogenic transformation.