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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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Journal ArticleDOI
Generalized Resistance to Thymic Deletion in the NOD Mouse: A Polygenic Trait Characterized by Defective Induction of Bim
Adrian Liston,Sylvie Lesage,Daniel H.D. Gray,Lorraine A. O'Reilly,Andreas Strasser,Aude M. Fahrer,Richard L. Boyd,Judith Wilson,Alan G. Baxter,Elena M. Gallo,Gerald R. Crabtree,Kaiman Peng,Sue Wilson,Christopher C. Goodnow +13 more
TL;DR: Findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity as well as a general deficit in TCR signaling to calcineurin- or ERK-induced genes.
Journal Article
NKT cell stimulation with glycolipid antigen in vivo
Nadine Y. Crowe,Adam P Uldrich,Petra Schnorrer,Yifan Zhan,Andrew M. Lew,Philippe Bouillet,Andreas Strasser,Jose A Villadangos,Mark J. Smyth,Dale I. Godfrey +9 more
TL;DR: Understanding of how NKT cells respond to primary and secondary antigenic challenge in vivo is significantly enhanced, suggesting that the pool size is regulated by apoptotic death, similar to that of conventional T cells.
Journal ArticleDOI
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis.
Takashi Yano,Kosei Ito,Hiroshi Fukamachi,Xin-Zi Chi,Hee-Jun Wee,Ken-ichi Inoue,Hiroshi Ida,Philippe Bouillet,Andreas Strasser,Suk-Chul Bae,Yoshiaki Ito +10 more
TL;DR: It is demonstrated that RUNX3 is responsible for transcriptional up-regulation of Bim in TGF-β-induced apoptosis, and apoptosis was reduced to the same extent as that in Bim−/− gastric epithelium.
Journal Article
E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.
TL;DR: To assess the lymphoid tumorigenic potential of bCl-2, mice of five independent strains expressing a bcl-2 transgene in B and/or T cells were monitored for disease up to 12 months of age, finding plasmacytomas secreting immunoglobulin and novel lymphomas that expressed markers consistent with an origin very early in B-lymphoid development.
Journal ArticleDOI
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim
Gayle M. Davey,Christian Kurts,Jacques F. A. P. Miller,Philippe Bouillet,Andreas Strasser,Andrew G. Brooks,Francis R. Carbone,William R. Heath +7 more
TL;DR: The molecular basis of cross-tolerance was investigated and Bim, a pro-apoptotic Bcl-2 family member whose function can be inhibited by B cl-2, was found to play a critical role in the deletion of autoreactive thymocytes, leading us to examine its role in cross-Tolerance.