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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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Journal Article
Effect of a bcl-2 transgene on production and localization of precursor B cells in mouse bone marrow
TL;DR: Findings provide evidence that, in addition to expanding the recirculating pool of B cells entering bone marrow from the blood stream, high levels of Bcl-2 can inhibit some of the apoptosis occurring during B cell differentiation, thereby expanding populations of B lymphopoietic precursor cells within the bone marrow parenchyma.
Journal ArticleDOI
Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation.
Lorraine A. O'Reilly,Peter Hughes,Ann Lin,Paul Waring,Ulrich Siebenlist,Rajan Jain,Daniel H.D. Gray,S Gerondakis,Andreas Strasser +8 more
TL;DR: Findings indicate that selective inhibition of c-REL may be an attractive strategy for the treatment of autoimmune pathologies driven by defects in FASL/FAS signaling that would be expected to circumvent many of the complications caused by pan-NF-κB inhibition.
Book ChapterDOI
The Role of bcl -2 in Lymphoid Differentiation and Neoplastic Transformation
TL;DR: Transgenic mice have been developed to test the possibility that the normal role of bcl-2 is to govern the life and death of lymphocytes during the generation and function of the immune system and to evaluate the oncogenic potential of bCl-2.
Journal ArticleDOI
Rapid Selection against Truncation Mutants in Yeast Reverse Two-Hybrid Screens
TL;DR: By fusing the green fluorescent protein (GFP) to the C-terminus of a protein of interest, dynein light chain (LC8), this work was able to rapidly isolate mutations that did not result in protein truncation.
Journal ArticleDOI
PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia
Andrew A. Guirguis,Christopher Slape,Laura M Failla,Jesslyn Saw,Cedric S. Tremblay,David R. Powell,Fernando J. Rossello,Andrew H. Wei,Andrew H. Wei,Andreas Strasser,David J. Curtis,David J. Curtis +11 more
TL;DR: Results suggest that targeting PUMA may improve the cytopenias of MDS without a detrimental effect on leukemic progression thus warranting further investigation.