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Andreas Strasser
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 537
Citations - 75592
Andreas Strasser is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 128, co-authored 509 publications receiving 66903 citations. Previous affiliations of Andreas Strasser include University of Alabama at Birmingham & Basel Institute for Immunology.
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Journal ArticleDOI
Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress
Alex R. D. Delbridge,Alex R. D. Delbridge,Joseph T. Opferman,Stephanie Grabow,Stephanie Grabow,Andreas Strasser,Andreas Strasser +6 more
TL;DR: Inhibition of proapoptotic p53 upregulated modulator of apoptosis (PUMA) is identified as the key role of MCL-1 in both settings, with Mcl-1(+/-);Puma(-/-) mice completely protected from the deleterious effects of loss of 1 M CL-1 allele.
Journal Article
A novel cellular model (SPGM 1) of switching between the pre-B cell and myelomonocytic lineages.
Michael U. Martin,Andreas Strasser,Andreas Strasser,Nicole Baumgarth,Nicole Baumgarth,Flavia M. Cicuttini,Flavia M. Cicuttini,Karen Welch,Karen Welch,Evelyn Salvaris,Evelyn Salvaris,Andrew W. Boyd,Andrew W. Boyd +12 more
TL;DR: SPGM1 has all the characteristic features of a CD5+ pre-B cell line, however, IL-3 predominantly induced SPGM1 to switch its differentiation program from a pre- B cell to a macrophage, providing a unique model for the molecular analysis of mechanisms involved in cell-fate determination.
Journal ArticleDOI
Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation
TL;DR: Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation and new ideas are proposed for designing and exploiting probabilistic chemoreception mechanisms.
Journal ArticleDOI
Loss of the Proapoptotic BH3-Only Protein BCL-2 Modifying Factor Prolongs the Fertile Life Span in Female Mice
Seng H. Liew,Kavitha Vaithiyanathan,Michele Cook,Phillipe Bouillet,Phillipe Bouillet,Clare L. Scott,Clare L. Scott,Jeffrey B. Kerr,Andreas Strasser,Andreas Strasser,John (Jock) K Findlay,Karla J. Hutt +11 more
TL;DR: The findings support an important role for BMF in determining the number of primordial follicles maintained in the ovary throughout adult reproductive life and thus indicate that the length of female fertility may be extended by increasing thenumber ofPrimordial follicle maintained within the Ovary through inhibition of BMF.
Journal ArticleDOI
PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.
Florian Wiede,Jarrod A Dudakov,Kun-Hui Lu,Garron T. Dodd,Tariq M. Butt,Dale I. Godfrey,Dale I. Godfrey,Andreas Strasser,Andreas Strasser,Richard L. Boyd,Tony Tiganis,Tony Tiganis +11 more
TL;DR: This work shows that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulating TCR versus TCR T cell development.