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Andrew D. Ellington
Researcher at University of Texas at Austin
Publications - 599
Citations - 48723
Andrew D. Ellington is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Aptamer & RNA. The author has an hindex of 96, co-authored 569 publications receiving 43262 citations. Previous affiliations of Andrew D. Ellington include Harvard University & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Effect of Complementary Nucleobase Interactions on the Copolymer Composition of RAFT Copolymerizations
TL;DR: In this paper, the reactivity ratios of monomer pairs were measured and calculated using a nonlinear least-squares (NLLS) method, and the results confirmed that the monomer reactivities were dependent on the solvent used for polymerization.
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The fidelity of template-directed oligonucleotide ligation and the inevitability of polymerase function.
TL;DR: A method for evaluating ligation fidelity in which ligation substrates are selected from random sequence libraries supports a model for origins in which there was selective pressure for template-directed oligon nucleotide ligation to be gradually supplanted by mononucleotide polymerization.
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Directed Evolution of a Panel of Orthogonal T7 RNA Polymerase Variants for in Vivo or in Vitro Synthetic Circuitry.
TL;DR: The directed evolution of a panel of orthogonal T7 RNA polymerase:promoter pairs that each specifically recognizes a synthetic promoter is presented, which can be used to independently control up to six circuits in parallel.
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Shaping up nucleic acid computation.
Xi Chen,Andrew D. Ellington +1 more
TL;DR: This review not only revisits several milestones in the field of nucleic acid-based computation, but also highlights how the prospects for nucleic Acid computation go beyond just a large address space.
Journal ArticleDOI
Transcription yield of fully 2′-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants
Adam J. Meyer,Daniel J. Garry,Bradley Hall,Michelle Byrom,Hannah G. McDonald,Xu Yang,Y. Whitney Yin,Andrew D. Ellington +7 more
TL;DR: It is shown that mutations previously shown to increase the thermal tolerance of T7 RNA polymerase can increase the activity of mutants with expanded substrate range, and the resulting polymerase mutants can be used to generate 2′-O-methyl modified RNA with yields much higher than enzymes currently employed.