Andrew D. Ellington

TL;DR: The development of lower-cost methods to produce high-quality synthetic DNA will allow for the exploration of larger biological hypotheses by lowering the cost of use and help to close the DNA read-write cost gap.

TL;DR: Two potential diagnostic applications of the selected allosteric ribozyme ligase are demonstrated: 'counting' short oligonucleotide effectors by RT-PCR, and counting a non-nucleic acid effector, ATP, by ligation.

TL;DR: The Account provides a means of touching on what might seem to be an arcane field, and explains nucleic acid amplification reactions that can lead to signal amplification, such as catalytic hairpin assembly and the hybridization chain reaction.

TL;DR: High-resolution proteomics analysis of immunoglobulin coupled with high-throughput sequencing of transcripts encoding B cell receptors to quantitatively determine the antibody repertoire at the individual clonotype level in the sera of young adults before and after vaccination with trivalent seasonal influenza vaccine reveals unanticipated insights regarding the serological response to influenza vaccination.

TL;DR: A fully integrated biosensor 10 × 10 array in a standard complementary metal-oxide semiconducor process, which takes advantage of electrochemical impedance spectroscopy (EIS), which is able to detect various biological analytes in real time and without the need for molecular labels.