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Andrew D. Ellington
Researcher at University of Texas at Austin
Publications - 599
Citations - 48723
Andrew D. Ellington is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Aptamer & RNA. The author has an hindex of 96, co-authored 569 publications receiving 43262 citations. Previous affiliations of Andrew D. Ellington include Harvard University & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips
Cheulhee Jung,John A. Hawkins,Stephen K. Jones,Yibei Xiao,James R. Rybarski,Kaylee E. Dillard,Jeffrey A. Hussmann,Fatema A. Saifuddin,Cagri A. Savran,Andrew D. Ellington,Ailong Ke,William H. Press,Ilya J. Finkelstein +12 more
TL;DR: A chip-hybridized association-mapping platform (CHAMP) that repurposes next-generation sequencing chips to simultaneously measure the interactions between proteins and ∼107 unique DNA sequences provides a framework for high-throughput, quantitative analysis of protein-DNA interactions on synthetic and genomic DNA.
Journal ArticleDOI
Functional interrogation and mining of natively paired human v H:V L antibody repertoires
Bo Wang,Brandon J. DeKosky,Brandon J. DeKosky,Morgan R. Timm,Jiwon Lee,Erica Normandin,John Misasi,Rui Kong,Jonathan R. McDaniel,George Delidakis,Leigh Kendra Elizabeth,Thomas Niezold,Chang W. Choi,Elise G. Viox,Ahmed S. Fahad,Alberto Cagigi,Aurélie Ploquin,Kwanyee Leung,Eun Sung Yang,Wing Pui Kong,William N. Voss,Aaron G. Schmidt,M. Anthony Moody,David R. Ambrozak,Amy R. Henry,Farida Laboune,Julie E. Ledgerwood,Barney S. Graham,Mark Connors,Daniel C. Douek,Nancy J. Sullivan,Andrew D. Ellington,John R. Mascola,George Georgiou +33 more
TL;DR: Using a technology to screen millions of B cells for natively paired human antibody repertoires, HIV-1 broadly neutralizing antibodies (bNAbs) from an HIV- 1 slow progressor and high-affinity neutralizing antibody against Ebola virus glycoprotein and influenza hemagglutinin are identified.
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A Pattern Recognition Based Fluorescence Quenching Assay for the Detection and Identification of Nitrated Explosive Analytes
TL;DR: A differential array of micelle-solubilized fluorophores for the detection and identification of small nitrated analytes, such as the explosives TNT, tetryl, RDX and HMX is reported.
Journal ArticleDOI
Technical and biological issues relevant to cell typing with aptamers.
Na Li,Jessica N. Ebright,Gwendolyn M. Stovall,Xi Chen,Hong Hanh Nguyen,Amrita Singh,Angel Syrett,Andrew D. Ellington +7 more
TL;DR: Difficulties in using aptamers for cell typing are identified and better understanding and controlling for the role of background and nonspecific binding to cells should open the way to using arrays of aptamer for describing and quantifying the cell surface proteome.
Journal ArticleDOI
A Simple, Cleated DNA Walker That Hangs on to Surfaces
TL;DR: A single-legged or unipedal walker that has a "cleat" that allows it to persistently associate with a track and make autonomous decisions about movement and should prove especially valuable for programming amorphous computations within chemical reaction networks.