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Andrew D. Ellington
Researcher at University of Texas at Austin
Publications - 599
Citations - 48723
Andrew D. Ellington is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Aptamer & RNA. The author has an hindex of 96, co-authored 569 publications receiving 43262 citations. Previous affiliations of Andrew D. Ellington include Harvard University & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Hachimoji DNA and RNA. A Genetic System with Eight Building Blocks
Shuichi Hoshika,Nicole A. Leal,Myong Jung Kim,Myong Sang Kim,Nilesh B. Karalkar,Hyo Joong Kim,Alison M. Bates,Norman E. Watkins,Holly A. SantaLucia,Adam J. Meyer,Saurja DasGupta,Joseph A. Piccirilli,Andrew D. Ellington,John SantaLucia,Millie M. Georgiadis,Steven A. Benner +15 more
TL;DR: DNA- and RNA-like systems built from eight nucleotide “letters” that form four orthogonal pairs that meet the structural requirements needed to support Darwinian evolution, including a polyelectrolyte backbone, predictable thermodynamic stability, and stereoregular building blocks that fit a Schrödinger aperiodic crystal are reported.
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Expression of small, therapeutic RNAs in human cell nuclei.
Paul D. Good,Alexandra Krikos,Shirley Li,Edouard Bertrand,N. S. Lee,Lori Giver,Andrew D. Ellington,J. A. Zaia,J. J. Rossi,David R. Engelke +9 more
TL;DR: In situ localization of the transcripts shows that both tRNA and U6 promoter transcripts give primarily punctate nuclear patterns, and that capping of transcripts is not required for nuclear retention, whereas other RNAs have little or no effect when expressed in these cassettes.
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Aptamer:toxin conjugates that specifically target prostate tumor cells
Ted C. Chu,John W. Marks,Laura A. Lavery,Sarah Faulkner,Michael G. Rosenblum,Andrew D. Ellington,Matthew Levy +6 more
TL;DR: The results validate the notion that "escort aptamers" may be useful for the treatment of specific tumors expressing unique antigen targets and promote uptake into target cells but also decreases the toxicity of gelonin in non-target cells.
Journal ArticleDOI
Quantum-dot aptamer beacons for the detection of proteins
TL;DR: This work designed a quantum-dot-based aptamer biosensor that can detect the small molecule maltose and utilized an aptamer that is known to bind the blood-clotting protein thrombin as a model system.
Journal ArticleDOI
Designed signaling aptamers that transduce molecular recognition to changes in fluorescence intensity
Sulay D. Jhaveri,Romy Kirby,Rick Conrad,Emily J. Maglott,Michael T. Bowser,Robert T. Kennedy,Gary D. Glick,Andrew D. Ellington +7 more
TL;DR: Two different anti-adenosine “signaling aptamers”, one made from RNA and one from DNA, can selectively signal the presence of adenosine in solution.