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Andrew D. Ellington
Researcher at University of Texas at Austin
Publications - 599
Citations - 48723
Andrew D. Ellington is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Aptamer & RNA. The author has an hindex of 96, co-authored 569 publications receiving 43262 citations. Previous affiliations of Andrew D. Ellington include Harvard University & UPRRP College of Natural Sciences.
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Directed evolution of gold nanoparticle delivery to cells
TL;DR: A newly selected anti-receptor (anti-EGFR) aptamer was conjugated to gold nanoparticles via a facile hybridization method and was found to specifically and quantitatively direct the delivery of gold nanoparticle to cells expressing EGFR through receptor-mediated endocytosis.
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DNA Detection Using Origami Paper Analytical Devices
TL;DR: The hybridization-induced fluorescence detection of DNA on an origami-based paper analytical device (oPAD) is demonstrated, proving to be successful in both detection systems.
A 'resource allocator' for transcription based on a highly fragmented T7 RNA polymerase
Thomas H. Segall-Shapiro,Adam J. Meyer,Andrew D. Ellington,Eduardo D. Sontag,Christopher A. Voigt +4 more
TL;DR: In this paper, a resource allocator that sets the core fragment concentration, which is then shared by multiple r fragments, is used to allocate transcriptional resources via different schemes, which demonstrate by building a system which adjusts promoter activity to compensate for the difference in copy number of two plasmids.
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Synthetic evolutionary origin of a proofreading reverse transcriptase
Jared W. Ellefson,Jimmy Gollihar,Raghav Shroff,Haridha Shivram,Vishwanath R. Iyer,Andrew D. Ellington +5 more
TL;DR: The evolutionarily distinct reverse transcription xenopolymerase (RTX) actively proofreads on DNA and RNA templates, which greatly improves RT fidelity and enables applications such as single-enzyme reverse transcription–polymerase chain reaction and direct RNA sequencing without complementary DNA isolation.