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Andrew D. Ellington
Researcher at University of Texas at Austin
Publications - 599
Citations - 48723
Andrew D. Ellington is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Aptamer & RNA. The author has an hindex of 96, co-authored 569 publications receiving 43262 citations. Previous affiliations of Andrew D. Ellington include Harvard University & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response
Yariv Wine,Daniel R. Boutz,Jason J. Lavinder,Aleksandr E. Miklos,R. E. Hughes,Kam Hon Hoi,Sang Taek Jung,Sang Taek Jung,Andrew P. Horton,Ellen M. Murrin,Andrew D. Ellington,Edward M. Marcotte,George Georgiou +12 more
TL;DR: The ability to deconvolute the polyclonal serum response is likely to be of key importance for analyzing antibody responses after vaccination and for more completely understanding adaptive immune responses in health and disease.
Journal ArticleDOI
Crystal structure of an RNA aptamer–protein complex at 2.8 Å resolution
M.A. Convery,Siân Rowsell,Nicola J. Storehouse,Andrew D. Ellington,Ichira Hirao,James B. Murray,James B. Murray,David S. Peabody,Simon E. V. Phillips,Peter G. Stockley +9 more
TL;DR: The crystal structure, at 2.8 Å resolution, of an RNA aptamer bound to bacteriophage MS2 coat protein has been determined, illustrating the ability of RNA to present similar molecular recognition surfaces from distinct primary and secondary structures.
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Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns.
TL;DR: Two examples of phylogenetic covariation that are most simply explained by postulating hydrogen-bonded base-triples similar to those found in tRNA are described.
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Directed evolution of genetic parts and circuits by compartmentalized partnered replication
Jared W. Ellefson,Adam J. Meyer,R. E. Hughes,Joe R. Cannon,Jennifer S. Brodbelt,Andrew D. Ellington +5 more
TL;DR: CPR is applied to evolve a T7 RNA polymerase variant that recognizes an orthogonal promoter and to reengineer the tryptophanyl tRNA-synthetase:suppressor tRNA pair from Saccharomyces cerevisiae to efficiently and site-specifically incorporate an unnatural amino acid into proteins.
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Engineered symbionts activate honey bee immunity and limit pathogens
Sean P. Leonard,J. Elijah Powell,Jiri Perutka,Peng Geng,Luke C. Heckmann,Richard D. Horak,Bryan William Davies,Andrew D. Ellington,Jeffrey E. Barrick,Nancy A. Moran +9 more
TL;DR: E engineered S. alvi can stably recolonize bees and produce double-stranded RNA to activate RNAi and repress host gene expression, thereby altering bee physiology, behavior, and growth and is a tool for studying bee functional genomics and potentially for safeguarding bee health.